A comparison of elemental analysis techniques requiring no sample preparation: scanning electron microscopy and laser induced breakdown spectroscopy

Heuser, Darryl J.; Walker, Dwight S.

doi:10.1039/b400801d

Cited by 6 publications

(4 citation statements)

References 5 publications

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“…Other works include application of LIBS for rapid on-line analysis of coating thickness and uniformity, 22 magnesium stearate content 31 during batch manufacturing of pharmaceutical tablets, and comparison of scanning electron microscopy and LIBS as solid-phase elemental analysis techniques requiring no sample preparations. 23 But these works have mostly been restricted to the analysis of bulk drugs in solid tablet form. In recent years, Mukherjee et al 24 developed a LIBS experimental methodology that allowed for real-time quantitative characterization of multi-component aerosols using an internal calibration scheme without the need for any sample preparation or external material standards.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Carbon-Containing Aerosolized Drugs Using Laser-Induced Breakdown Spectroscopy

Mukherjee

Cheng

2008

Appl Spectrosc

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Aerosolized drug delivery methods have increasingly become popular for pharmaceutical applications. This is mainly due to their ease of application and the more recent advancements incorporating nano-sized generation of particles that find deeper penetration routes and more efficient administration of the drug to specific target organs. Their effectiveness heavily relies on the uniformity of the chemical composition of these aerosolized drugs. Thus, it calls for a real-time on-line analytical tool that can accurately characterize the chemical constituents of the drug powder particles generated to ensure a stringent quality control. We present laser-induced breakdown spectroscopy (LIBS) for the first time as an efficient analytical tool to carry out on-line quantitative chemical characterization of aerosolized drugs. We used three different carbon based aerosolized drugs, namely L-ascorbic acid 2-phosphate sesquimagnesium salt hydrate (C(6)H(9)Mg(1.5)O(9)P.xH(2)O), Iron(II) L-ascorbate (C(12)H(14)FeO(12)), and DL-pantothenic acid hemicalcium salt (C(9)H(16)NO(5)0.5Ca) for our quantitative LIBS studies here. Our results show that LIBS can effectively estimate the quantitative ratios of carbon to various trace elements for each of these drugs, thereby enabling on-line unique characterization of individual aerosolized drugs. The quantitative LIBS technique predicted the [C]/[Mg], [C]/[Fe], and [C]/[Ca] ratios as 4.02+/-0.76, 12.42+/-2.36, and 18.47+/-4.39 for each of the above aerosolized drugs, respectively. Within error limits, we find these ratios in good agreement with the respective stoichiometric values of 4, 12, and 18 corresponding to the drugs above. Thus, the work demonstrated the utility and validity of LIBS in accurate on-line identification of drug powders during real-time manufacturing processes.

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Section: Introductionmentioning

confidence: 99%

Characterization of Carbon-Containing Aerosolized Drugs Using Laser-Induced Breakdown Spectroscopy

Mukherjee

Cheng

2008

Appl Spectrosc

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“…The lateral spatial resolution available for LIBS elemental mapping is much lower than those of other analytical methods that use electron beams, such as SEM-EDS. 105 The dimension of the ablation crater places a severe limitation on the spatial resolution. In addition, the analytical performance, precision, and repeatability of the analytical result are generally inferior to those of other types of plasma spectrometry, for instance, laser ablation ICP-MS. 106 For further practical applications and improvements in LIBS techniques for plant science, some additional methodology developments may be suggested.…”

Section: Discussionmentioning

confidence: 99%

Review: Application Of LIBS To Elemental Analysis And Mapping Of Plant Samples

Singh¹

2021

At.Spectrosc.

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Trace minerals and metallic elements play a key role in plant metabolism and function. Therefore, it is important to understand the movement and distribution of trace minerals within various parts of plants in order to understand their metabolic pathways. Information on the localization of minerals can be utilized in the fields of plant science, agriculture, and food technologies. In this context, herein, we review the feasibility of application of laser-induced breakdown spectroscopy (LIBS) as a technique for trace element detection and mapping in different plant matrices. LIBS is a well-established technique that can be used to perform rapid multi-elemental detection in various types of samples, including plants. Owing to the unique capabilities of LIBS, its field applications are growing rapidly, particularly in the area of plant science. Here, our primary emphasis is on the quantitative and qualitative elemental imaging of different varieties of plant species that are of importance as medicines and foodstuffs. In this review article, we present an exhaustive survey of recent developments, including technical advances and recent work involving the detection of nanoparticles in plant samples and in the monitoring of soil content. The future potential of LIBS and the viability of its possible applications to the detection of essential minerals and heavy metals in plants used as foods or of medicinal importance are also discussed.

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“…23 Soon after, a wide range of pharmaceutical applications for LIBS began to emerge. [24][25][26][27][28][29][30][31][32] These applications include the monitoring of the active pharmaceutical ingredients (API) and a formulation lubricant such magnesium stearate 29 as well as the possibility of generating the first results capable of globally mapping pharmaceutical solid dosage forms. 26 As is typical in NIR and Raman reflectance spectroscopy, pure components are analysed before their preparation in a solid dosage form.…”

Section: -14mentioning

confidence: 99%

“…The technique has also been compared to traditional analytical techniques, such as scanning electron microscope coupled with energy dispersive X-ray emission (SEM-EDX) 31 and with nearinfrared (NIR) spectroscopy, for determination of magnesium stearate, a critical formulation ingredient necessary for ensuring product performance. 32 The efforts of these early LIBS researchers have highlighted the presence of the ''matrix effect''.…”

mentioning

confidence: 99%

Quantitative molecular analysis with molecular bands emission using laser-induced breakdown spectroscopy and chemometrics

Doucet¹,

Faustino²,

Sabsabi³

et al. 2008

J. Anal. At. Spectrom.

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The present work describes the first quantitative molecular prediction using laser-induced molecular bands along with chemometrics. In addition, this spectroscopic procedure has demonstrated the first complete quantitative analysis utilizing traditionally insensitive elements for pharmaceutical formulations. Atomic LIBS requires certain sensitive elements, such as Cl, F, Br, S and P, in order to quantitate a specific organic compound in a complex matrix. Molecular LIBS has been demonstrated to be the first successful approach using atomic spectroscopy to evaluate a complex organic matrix. This procedure is also the first quantitative analysis using laser-induced molecular bands and chemometrics. We have successfully applied chemometrics to predict the formulation excipients and active pharmaceutical ingredient (API) in a complex pharmaceutical formulation. Using such an approach, we demonstrate that the accuracy for the API and a formulation lubricant, magnesium stearate, have less than 4% relative bias. The other formulation excipients such as Avicel Ò and lactose have been accurately predicted to have less than a 15% relative bias. Molecular LIBS and chemometrics have provided a novel approach for the quantitative analysis of several molecules that was not technically possible with the traditional atomic LIBS procedure, that required sensitive elements to be present in both API and formulation excipients.

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A comparison of elemental analysis techniques requiring no sample preparation: scanning electron microscopy and laser induced breakdown spectroscopy

Cited by 6 publications

References 5 publications

Characterization of Carbon-Containing Aerosolized Drugs Using Laser-Induced Breakdown Spectroscopy

Characterization of Carbon-Containing Aerosolized Drugs Using Laser-Induced Breakdown Spectroscopy

Review: Application Of LIBS To Elemental Analysis And Mapping Of Plant Samples

Quantitative molecular analysis with molecular bands emission using laser-induced breakdown spectroscopy and chemometrics

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