A Comparison of Fats of Varying Saturation as Inhibitors of Canine Gastric Secretion

Long, James F.; Brooks, Frank P.; Sandweiss, David J.

doi:10.1016/s0016-5085(19)34827-9

Cited by 10 publications

(4 citation statements)

References 8 publications

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“…Failure of the acid secretion to return to normal rates in most of our patients, within the time of the test, again confirms other work (Sircus, 1958;Long, Brooks, and Sandweiss, 1963) where an inhibitory period of between 90 and 120 minutes is recorded. Long et al(1963) noted that the acid output after food was delayed by the period of reduced secretion induced by fat, reaching the expected output by the end of a six-hour period. This could be due to a reduction in stomach motility after fat has been introduced into the duodenum, delaying gastrin release from the antrum.…”

Section: Discussionsupporting

confidence: 91%

“…Khizhin, Lobasov, and Sokolov, quoted by Pavlov (1910), demonstrated reduced gastric secretion following the introduction of acid and fat into the duodenum. Since then many workers have confirmed these findings for acid (Sircus, 1958;Andersson, 1960;Konturek and Grossman, 1965) and fat (Lim, Ivy, and McCarthy, 1925;Menguy, 1960;Long, Brooks, and Sandweiss, 1963).…”

mentioning

confidence: 80%

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Inhibition of gastric secretion in man by intestinal fat infusion.

Windsor¹,

Cockel²,

Lee³

1969

Gut

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Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 80%

Inhibition of gastric secretion in man by intestinal fat infusion.

Windsor¹,

Cockel²,

Lee³

1969

Gut

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“…O. Szabo and R.J. Mahler Department of Medicine, New York Medical College, New York, N.Y. 10029 The ingestion of fatty acid results in inhibited gastric acid secretion in response to certain foodstuffs (Long, Brooks, Sandweiss, 1963;LonK, LaVigne, 1969). In the present study this observation was applied to test the influence of an inhibited gastric acid secretory response upon oral carbohydrate tolerance.…”

Section: The Influence Of Fatty Acid Ingestion Upon Oral Glucose Tolementioning

confidence: 99%

The Influence of Fatty Acid Ingestion Upon Oral Glucose Tolerance

Szabó¹,

Rj²

1971

Horm Metab Res

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“…Acid concentration was determined by microtitration to pH 7 with phenol red as indicator. Pepsin was determined by the haemoglobin substrate method using commercial bovine haemoglobin [Long et at., 1963]. Basal gastric secretion was collected for 1 hr.…”

mentioning

confidence: 99%

The Comparative Gastric Acid and Pepsin Response to Histamine, Insulin Hypoglycemia and Feeding in Dogs With Vagally Innervated Gastric Pouches

Long

Brooks

1965

Exp Physiol

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The amounts of acid and of pepsin secreted by the stomach in response to a meal and to two dose levels of histamine and insulin have been compared in eight dogs with vagally-innervated pouches. The greatest acid output occurred after a 'maximal' dose of histamine, while the output after a meat meal usually exceeded that after either dose level of insulin. Feeding was better simulated, in the secretion it evoked, by 0-45 pug./kg./min. of histamine than by any other stimulus used.Large doses of histamine appeared to inhibit pepsin secretion in comparison with a submaximal dose. Both doses of -insulin stimulated pepsin secretion to a greater degree than did feeding.COMPARATIVE studies on the gastric secretory response to histamine, insulin hypoglycemia, and feeding have been described by several authors [Andersson et al., 1958;Babkin, 1950;Bucher et at., 1941;Davis and Brooks, 1963; Gregory, 1962]. However, a comparison between the acid and pepsin response to various doses of these pharmacological agents and to feeding has not been reported. This study was designed to investigate gastric secretion in response to all the above mentioned forms of stimulation in dogs equipped with vagally innervated pouches. METHODSEight dogs were prepared with vagally-innervated gastric pouches as described by Thomas [1942] and modified by Watman and Nasset [1950]. To obtain these preparations, we operated upon fourteen other dogs which proved to have incomplete mucosal bridges between the main stomach and the pouch. Six were recognized postoperatively and the others perforated between 1 and 3 months after the surgery.Glucose and saline solution was given intravenously for the first two postoperative days. Milk was offered on the 3rd day and pablum was added on the 4th and 5th days. Water was given ad libitum after the 4th day and canned dog food was begun in small amounts on the 5th day. After the 10th postoperative day, the animals were on their usual diet.We believe that suturing all three layers of the mucosal bridge with 3-0 silk instead of catgut, and bringing the stainless steel pouch cannula through the abdominal wall just to the left of the midline rather than laterally, have given a lower incidence of breakdown of the mucosal septum.

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A Comparison of Fats of Varying Saturation as Inhibitors of Canine Gastric Secretion

Cited by 10 publications

References 8 publications

Inhibition of gastric secretion in man by intestinal fat infusion.

Inhibition of gastric secretion in man by intestinal fat infusion.

The Influence of Fatty Acid Ingestion Upon Oral Glucose Tolerance

The Comparative Gastric Acid and Pepsin Response to Histamine, Insulin Hypoglycemia and Feeding in Dogs With Vagally Innervated Gastric Pouches

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