Inhibition of gastric secretion in man by intestinal fat infusion.

Windsor, C. W. O.; Cockel, R.; Lee, M. J. R.

doi:10.1136/gut.10.2.135

Cited by 34 publications

(12 citation statements)

References 36 publications

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“…Presumably fat releases hormonal inhibitors of acid secretion (15,16) [pH 5.0] peptic digestion is inhibited and peptides and amino acids would not be liberated from albumin in the stomach lumen.) However, both in the present studies and in our previous studies, steak in somewhat larger quantities is a potent stimulant of acid secretion and gastrin release (2,3).…”

Section: Resultsmentioning

confidence: 99%

Studies on the mechanisms of food-stimulated gastric acid secretion in normal human subjects.

Richardson¹,

Walsh²,

Hicks³

et al. 1976

J. Clin. Invest.

145

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A B S T R A C T Liquid test meals were infused into the stomach and acid secretion was measured by intragastric titration at pH 5.0. Acid secretion after 500 or 750-ml sodium chloride meals was two to three times higher than basal secretion rates and was equivalent to 25-30% of the peak acid output in response to histamine. Since these meals did not cause a rise in serum gastrin concentration, it is assumed that they stimulate acid secretion by causing distention of the body and fundus of the stomach. Compared with this distention stimulus, glucose meals had no effect on acid secretion and fatinhibited acid secretion; however, both glucose and fat caused an increase in serum gastrin concentration. Amino acids caused a much greater increase in serum gastrin concentration and enhanced acid secretion above that noted with distention alone. In contrast, albumin did not enhance the serum gastrin concentration or stimulate acid secretion to a statistically significant extent.There was a close correlation between the rise in serum gastrin concentration and rate of acid secretion after different test meals when average results for each test meal were plotted. However, there was a poor correlation between acid secretion and serum gastrin concentration when the responses of the individual subjects with a given test meal were compared.Our interpretations are: (a) Distention is an important stimulant of the acid-secretory response to a meal, and this is not mediated by gastrin release. (b) Gastrin is one but probably not the only mediator of the chemical phase of acid secretion, i.e., acid secretion noted with amino acids that cannot be explained by distention. (c) Glucose and fat also release gastrin; however, with

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Section: Resultsmentioning

confidence: 99%

Studies on the mechanisms of food-stimulated gastric acid secretion in normal human subjects.

Richardson¹,

Walsh²,

Hicks³

et al. 1976

J. Clin. Invest.

145

View full text Add to dashboard Cite

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“…The effect of different fatty substances upon the histamine or pentagastrinstimulated secretory plateau have been investigated in man (3,9,14,18). The experimental conditions of these studies are summarized in table 111.…”

Section: Discussionmentioning

confidence: 99%

“…The experimental conditions of these studies are summarized in table 111. Some authors (9,18) used large volumes with high fat contents exceeding by far the physiological amount of fat released by the stomach. In the present study, a 20-ml volume was chosen, supposing that no more than 20 ml are transferred with each cycle of gastric emptying (7).…”

Section: Discussionmentioning

confidence: 99%

“…In agreement with the experiments of other authors, no alteration of the acid output was observed during the time when the balloon was inflated (4). The pentagastrinstimulated secretory plateau is inhibited by instillation of hyperosmolar or hypoosmolar solutions into the duodenum in man (18). Therefore the solutions were adjusted on an approximate plasma isosmolality.…”

Section: Discussionmentioning

confidence: 99%

“…Myristate was ineffective. These results could suggest that different receptors are responsible' for fat-induced inhibition of the gastric acid secretion.Motility and gastric secretion in man are reduced by food containing fat (1, 5, 10).-This extensively studied inhibitory effect (3,9,12,13,16,18) is more effective with fatty acids than with triglycerides (15) and when the lipids are applied in form of emulsions (11). However, precise information on the relation ships between the intensity and duration of the gastric secretory inhibition and the quality or quantity of intraduodenal fat is still lacking.…”

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confidence: 99%

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Effect of Fatty Acids on the Stimulated Gastric Secretion in Man

Schmidt-Wilcke¹,

Steinhagen²,

Steinhagen³

et al. 1975

Digestion

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Solutions and emulsions of sodium or potassium salts in a series of saturated fatty acids from C₈ to C₁₈ were given in a dose of 0.5 g intraduodenally to healthy males or patients with healed duodenal ulcer. A double-lumen Sarles tube with a balloon placed in the proximal duodenum was used. The substances were instilled after a plateau of gastric acid secretion induced by a continuous infusion of pentagastrin was reached. In order to exclude unspecific effects, the test solutions were adjusted to a pH around 7.0 and to plasma isosmolality. Compared with the other tested substances, the emulsion of 0.5 g sodium-oleate was the most effective in inhibiting the stimulated gastric acid secretion. Sodium caprinate and caprylate had a considerable, but smaller effect than oleic acid on the secretory plateau. Palmitate and laurate provoked only a slight decrease in acid secretion. Myristate was ineffective. These results could suggest that different receptors are responsible’ for fat-induced inhibition of the gastric acid secretion.

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The effect of vagotomy on the inhibition of gastric secretion by intraduodenal fat

As¹

1973

Journal of British Surgery

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It has been suggested that the inhibition of gastric secretion by intraduodenal fat is a vagal phenomenon in man. Selective and highly selective vagotomy, by preserving this reflex, could offer advantages over truncal vagal section. This paper reports the effect of intraduodenal fat on pentagastrin‐stimulated gastric secretion in duodenal ulcer patients before and after truncal vagotomy. Marked inhibition of gastric secretion occurred in all the patients. In the postoperative group gastric secretion was almost totally abolished following fat infusion despite the absence of an abdominal vagal supply. The results suggest that inhibition of gastric secretion by intraduodenal fat is mediated by a nonvagal mechanism in man; from this point of view, therefore, there is little advantage in attempting to preserve the nerve‐supply to the duodenum at vagotomy.

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Inhibition of gastric secretion in man by intestinal fat infusion.

Cited by 34 publications

References 36 publications

Studies on the mechanisms of food-stimulated gastric acid secretion in normal human subjects.

Studies on the mechanisms of food-stimulated gastric acid secretion in normal human subjects.

Effect of Fatty Acids on the Stimulated Gastric Secretion in Man

The effect of vagotomy on the inhibition of gastric secretion by intraduodenal fat

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