A Comparison of Gabapentin and Ketamine in Acute and Chronic Pain After Hysterectomy

Abstract

Gabapentin and ketamine are similar in improving early pain control and in decreasing opioid consumption; however, gabapentin also prevented chronic pain in the first 6 postoperative months.

Preventive Analgesia and Novel Strategies for the Prevention of Chronic Post-Surgical Pain

“…In the first study, postoperative pain scores were significantly lower in patients treated with gabapentin as compared to patients who received ketamine or placebo. In this trial, a 0.3 mg/kg intravenous (IV) bolus and 0.05 mg/ kg per hour infusion of ketamine was not found to be significantly different to placebo [25]. In a study of 120 patients, Dullenkopf [55] did not find a difference in pain scores at 3 months between patients treated with placebo and either 0.15 mg/kg ketamine IV or 0.5 mg/kg ketamine IV given pre-incision.…”

“…However, at the 6-month time-point, it is important to recognize that only two studies were included in the analysis [23,24]. In two studies that were excluded from Sen et al [25,26], postoperative pain scores were significantly lower in the gabapentin group compared with both the ketamine and control groups at 3-and 6-month follow-up following hysterectomy and inguinal herniorrhaphy, respectively. In the remaining excluded gabapentin trial, no significant difference was found between gabapentin and placebo for pain characteristics at 6 months [27].…”

A Comparative Study of Effect of Intravenous Lidocaine Infusion, Gabapentin and Their Combination on Postoperative Analgesia after Thyroid Surgery

“…The analgesic effect of gabapentin was detected in the study of Sen et al [38] in patients undergoing abdominal hysterectomy, which compared the effect of gabapentin 1200 mg to ketamine group which ingested oral placebo capsules, then IV bolus of ketamine 0.3 mg/kg before incision then 0.05 mg/kg/hour IV infusion of ketamine until the end of operation; they detected that group received gabapentin had significantly lower pain scores compared to ketamine and control groups with significant decreased opioid requirement in gabapentin and ketamine groups compared to control group (P < 0.001).…”

Preemptive Analgesic Efficacy of Gabapentin and Nimesulide in the Functional Endoscopic Sinus Surgery

“…Bulgularımıza benzer olarak, Sen ve ark., [27] histerektomi sonrası akut ve kronik ağrıda ketamin ve gabapentini karşılaştırdıkları çalışmada, ameliyat öncesi olarak bir gruba ketamin 0.3 mg/kg/ IV verilmiştir. Diğer gruba oral yolla gabapentin verilmiş.…”