A comparison of gas chromatography coupled to tandem quadrupole mass spectrometry and high-resolution sector mass spectrometry for sensitive determination of polycyclic aromatic hydrocarbons (PAHs) in cereal products

Rozentale, Irina; Začs, Dzintars; Pērkons, Ingus; Bartkevičs, Vadims

doi:10.1016/j.foodchem.2016.11.027

Cited by 35 publications

(18 citation statements)

References 11 publications

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“…The LOD for other studied PAHs varies within range from 0.003 to 0.01 μg/kg . Similar LODs (0.002–0.006 μg/kg) were achieved for benzo[a]pyrene, benzo[b]fluoranthene, benzo[a]anthracene, and chrysene in bakery products with similar instrument setup. Another important food processing contaminant, often present in smoked or grilled products, is 3‐monochloropropane‐1,2‐diol (3‐MCPD).…”

Section: Food Analysissupporting

confidence: 66%

Recent applications of gas chromatography with high‐resolution mass spectrometry

S̆pánik¹,

Machyňáková²

2017

J of Separation Science

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Gas chromatography coupled to high-resolution mass spectrometry is a powerful analytical method that combines excellent separation power of gas chromatography with improved identification based on an accurate mass measurement. These features designate gas chromatography with high-resolution mass spectrometry as the first choice for identification and structure elucidation of unknown volatile and semivolatile organic compounds. Gas chromatography with high-resolution mass spectrometry quantitative analyses was previously focused on the determination of dioxins and related compounds using magnetic sector type analyzers, a standing requirement of many international standards. The introduction of a quadrupole high-resolution time-of-flight mass analyzer broadened interest in this method and novel applications were developed, especially for multi-target screening purposes. This review is focused on the development and the most interesting applications of gas chromatography coupled to high-resolution mass spectrometry towards analysis of environmental matrices, biological fluids, and food safety since 2010. The main attention is paid to various approaches and applications of gas chromatography coupled to high-resolution mass spectrometry for non-target screening to identify contaminants and to characterize the chemical composition of environmental, food, and biological samples. The most interesting quantitative applications, where a significant contribution of gas chromatography with high-resolution mass spectrometry over the currently used methods is expected, will be discussed as well. K E Y W O R D Saccurate mass measurement, environmental analysis, gas chromatography, high-resolution mass spectrometry, pesticide residues

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Section: Food Analysissupporting

confidence: 66%

Recent applications of gas chromatography with high‐resolution mass spectrometry

S̆pánik¹,

Machyňáková²

2017

J of Separation Science

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“…Based on earlier experience on quantification of genotoxic impurities in different drug substances, the quantitative method was developed for the determination of 3,3-dimethylallyl bromide genotoxic impurity in tazarotene drug substance by GC-MS [14][15][16]. Many other analytical methods were available to determine the genotoxic impurities by LC-MS/MS and GC-MS [17][18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Quantitative method for determination of 3,3‐dimethylallyl bromide genotoxic impurity in Tazarotene drug substance by GC‐MS

Rajana

Ramana

Babu

et al. 2020

Separation Science Plus

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A highly sensitive gas chromatography‐mass spectrometry quantitative method was developed for 3,3‐dimethylallyl bromide genotoxic impurity in the tazarotene drug substance. The method was validated by following the International conference for harmonization Q2 (R1) guideline for the limit test of 3,3‐dimethylallyl bromide genotoxic impurity in the tazarotene drug substance. The 148 m/z, 150 m/z, and 69 m/z ions were selected to get a response in mass spectrometry for 3,3‐dimethylallyl bromide. DB‐1 (30 mm × 0.25 × 1.0 µm) column was used for the separation of 3,3‐dimethylallyl bromide from the sample matrix. The limit of detection and limit of quantitation for 3,3‐dimethylallyl bromide in this method was 0.7 and 2.1 ppm, respectively. The method was precise and accurate at limit of quantitation level, 1.7% RSD was observed at limit of quantitation precision and 100.9% recovery observed at limit of quantitation accuracy, it was linear from the 5 to 20 µg/L, the correlation coefficient (r) was 0.9996.

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“…For their accurate and precise measurements, chromatographic methods using gas chromatography (GC) or high performance liquid chromatography (HPLC) have been developed and evaluated extensively . One alternative is using gas chromatography coupled to mass spectrometry (GC‐MS), a tandem of mass spectrometers (GC‐MS/MS) or flame ionization detection has been used . As known, as PAHs present at low levels with the complicated matrix in foodstuffs and environment samples, the sample preparation is became a necessary step before sample analysis.…”

Section: Introductionmentioning

confidence: 99%

Enrichment and determination of sixteen trace polycyclic aromatic hydrocarbons in barbecue smoke by using a continuous magnetic solid‐phase extraction and gas chromatography‐mass spectrometry

Pan

Zhang

Peng

et al. 2020

Separation Science Plus

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In this study, an innovative approach is proposed to predict the contribution of sixteen polycyclic aromatic hydrocarbons in barbecue smoke based on magnetic solid-phase extraction system and gas chromatography-mass spectrometry. In order to improve the detection limit of gas chromatography-mass spectrometry, a kinds of magnetic nanomaterial synthesized previously was used as a sorbent in magnetic solid-phase extraction. The recoveries ranged from 73.4% to 90.7%, and the limits of detection and limits of quantification were in the range 1.2-5.4 ng⋅L −1 and 3.7-16.4 ng⋅L −1 respectively. The method was successfully applied to the analysis of polycyclic aromatic hydrocarbons in smoke of the pork belly. The developed method could be potentially used for the assessing of polycyclic aromatic hydrocarbons profiles in environment pollution. K E Y W O R D Sgas chromatography-mass spectrometry, magnetic solid-phase extraction, polycyclic aromatic hydrocarbons Article Related

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A comparison of gas chromatography coupled to tandem quadrupole mass spectrometry and high-resolution sector mass spectrometry for sensitive determination of polycyclic aromatic hydrocarbons (PAHs) in cereal products

Cited by 35 publications

References 11 publications

Recent applications of gas chromatography with high‐resolution mass spectrometry

Recent applications of gas chromatography with high‐resolution mass spectrometry

Quantitative method for determination of 3,3‐dimethylallyl bromide genotoxic impurity in Tazarotene drug substance by GC‐MS

Enrichment and determination of sixteen trace polycyclic aromatic hydrocarbons in barbecue smoke by using a continuous magnetic solid‐phase extraction and gas chromatography‐mass spectrometry

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