A comparison of in vitro storage markers between Gamma-irradiated and non-irradiated apheresis platelet concentrates (APC)

The effect of gamma irradiation on the quality of apheresis platelets during storage for 7 days

“…We found no difference in pH between irradiated and control PCs, which is in accordance with some previous reports 4,12,13,16,17 . There are, however, also studies that have reported differences in pH between irradiated and nonirradiated PCs 3,11 . The only difference we found in blood gases between irradiated and control PCs was for pCO 2 , which was higher in nonirradiated PCs on Day 7 (p < 0.05).…”

“…Glucose and lactate levels were similar in the irradiated and nonirradiated PCs as have been shown by others in apheresis PCs stored for 5 days 4,11 . Bessos and coworkers, 3 in contrast, reported lower lactate levels in apheresis PCs irradiated with 25 Gy compared to nonirradiated PCs on Day 5 of storage. HSR and swirling were well maintained during 7 days of storage and at a similar level for irradiated and control PCs.…”

“…We compared the quality of an irradiated apheresis platelet concentrate (PC) to a nonirradiated control PC from the same donor and donation. Previous reports have shown varying in vitro and in vivo results regarding the effect of gamma irradiation on PLT quality 3‐5 …”

Effect of gamma radiation on the in vitro aggregability of WBC‐reduced apheresis platelets

“…Early studies evaluated the immediate effects of gamma radiation on unstored platelets that had been prepared as PRP‐PCs or BC‐PCs 17–19 20–28 . However, there are only a few studies on the irradiation of SDPs obtained by apheresis 24–28 .…”

“…Later reports examined the effects of storage and subsequent irradiation and of irradiation and subsequent storage on the properties of platelet components 20–28 . However, there are only a few studies on the irradiation of SDPs obtained by apheresis 24–28 . The in vivo studies have shown that irradiation with up to 5000 cGy does not impair the survival of platelets in the recipient after transfusion, but some in vitro properties may be altered.…”