A Comparison of Low Volume, Draize and in vitro eye irritation test data. II. Oil/water emulsions

Gettings, S.D.; Lordo, Robert A.; Feder, Paul I.; Hintze, K. L.

doi:10.1016/s0278-6915(97)00110-5

Cited by 20 publications

(8 citation statements)

References 13 publications

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“…Many studies have been undertaken to test the reproducibility and predictability of the LVET (55)(56)(57)(58). Some of these have shown that it can provide better predictions of the human response to eye irritation than the standard Draize test.…”

Section: Opportunities For Reducing and Refining The Use Of Animalsmentioning

confidence: 99%

An Integrated Decision-tree Testing Strategy for Eye Irritation with Respect to the Requirements of the EU REACH Legislation

et al. 2008

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This paper presents some results of a joint research project, sponsored by Defra and conducted by FRAME and Liverpool John Moores University, on the status of alternatives to animal testing with regard to the European Union REACH (Registration, Evaluation and Authorisation of Chemicals) system for the safety testing and risk assessment of chemicals. The project covered all the main toxicity endpoints associated with REACH. This paper focuses on the use of alternative (non-animal) methods (both in vitro and in silico) for eye irritation testing. The manuscript reviews numerous in vitro tests and their possible collation into test batteries, in silico models and a refined in vivo method (the low volume eye test), before combining the use of all these methods into an integrated testing strategy. The aim of this strategy is a reduction in the number of animal tests which would need to be performed in the process of fulfilling the REACH system criteria; this would also lead to a lowering of the number of animals required in compliance with the REACH system requirements.

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Section: Opportunities For Reducing and Refining The Use Of Animalsmentioning

confidence: 99%

An Integrated Decision-tree Testing Strategy for Eye Irritation with Respect to the Requirements of the EU REACH Legislation

et al. 2008

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“…The LVET has been evaluated with good reproducibility in several studies by different laboratories, for example in the multicentre study involving six different laboratories organized by OPAL (84), in the alternatives programme of the SDA ( 93), by Cormier et al (202), and in the CTFA programme (203)(204)(205). The linear correlation for LVET data and Draize MAS scores was 0.93 (93,203).…”

Section: Status Of Validation And/or Standardisationmentioning

confidence: 99%

3.3. Eye Irritation

et al. 2005

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“…1 LNEs are also promising vehicles for drug administration because of their features of sustained release, targeted delivery, as well as reduced irritation and drug toxicity. [2][3][4] LNEs with an oil-like lipid matrix are commonly prepared by incorporating drugs into the interior oil phase or into the oil-water interface. 5 Therefore, unstable drugs with poor aqueous A specific type of lipid nanoparticles known as longcirculating lipid nanoparticles has been developed.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characteristics of lipid nanoemulsion formulations loaded with doxorubicin

Jiang¹,

He²,

Li³

et al. 2013

IJN

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A Comparison of Low Volume, Draize and in vitro eye irritation test data. II. Oil/water emulsions

Cited by 20 publications

References 13 publications

An Integrated Decision-tree Testing Strategy for Eye Irritation with Respect to the Requirements of the EU REACH Legislation

An Integrated Decision-tree Testing Strategy for Eye Irritation with Respect to the Requirements of the EU REACH Legislation

3.3. Eye Irritation

Preparation and characteristics of lipid nanoemulsion formulations loaded with doxorubicin

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