A comparison of mammographic parenchymal patterns in premenopausal Japanese and British women

Gravelle, I. H.; Bulbrook, R. D.; Wang, D. Y.; Allen, D S; Hayward, John; Bulstrode, J. C.; Takatani, Osamu

doi:10.1007/bf02633537

Cited by 16 publications

(9 citation statements)

References 14 publications

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“…In our study, the mean percent density was comparable in all age groups between the Caucasian and the Hispanic women. Conflicting results have been reported between the Asian women and the Caucasian women, 21,[23][24][25][26] some showing significant differences while others not. A large study using BI-RADS score to classify the subjects into fatty ͑BI-RADS 1-2͒ and dense ͑BI-RADS 3-4͒ breasts found that the Asian women had significantly denser breasts than the Caucasian women, and that the differences were greatest in the older age groups.…”

Section: Discussionmentioning

confidence: 93%

Age‐ and race‐dependence of the fibroglandular breast density analyzed on 3D MRI

Nie¹,

Su²,

Chau

et al. 2010

Medical Physics

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Section: Discussionmentioning

confidence: 93%

Age‐ and race‐dependence of the fibroglandular breast density analyzed on 3D MRI

Nie¹,

Su²,

Chau

et al. 2010

Medical Physics

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“…A case‐control study showed that women with breast cancer were nearly 7 times as likely to be classified as one of the high‐risk Wolfe categories than controls 19. Normal premenopausal Japanese women were found to have significantly more favorable mammographic patterns (Wolfe grades20) than British women 21. Results from a mammography screening study using Wolfe's classification scheme suggest a very low prevalence of the DY (mammary dysplasia) patterns 22.…”

Section: Discussionmentioning

confidence: 99%

Comparison of mammographic densities and their determinants in women from Japan and Hawaii

Maskarinec

Nagata

Shimizu

et al. 2002

Intl Journal of Cancer

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Breast cancer incidence increases considerably in women who migrate from Japan to the United States. Based on the hypothesis that mammographic density in healthy mammograms reflects differences in breast cancer risk, we compared mammographic density in 3 groups of women at different levels of risk: Caucasian and Japanese women in Hawaii and Japanese women in Japan. In a cross-sectional design, preand postmenopausal women without a history of breast cancer and with a mammogram free of suspicious lesions were recruited in mammography clinics and completed a selfadministered questionnaire. Cranio-caudal mammograms were scanned into a computer and the densities measured using a computer-assisted method. Statistical analyses included ANOVA and multiple linear regression. Breast size among women of Japanese ancestry was similar in Hawaii and Japan but 50% smaller than that among Caucasian women. Dense areas were smallest among women in Japan, intermediate among Japanese women in Hawaii and largest among Caucasian women. Percent densities were greater in Japanese women than Caucasian women because of the larger breast sizes in Caucasians. However, percent densities were significantly higher among Japanese women in Hawaii than in Japan. These results indicate that the size of the total breast differs primarily by ethnicity and the size of the dense areas differs mainly by place of residence. Therefore, when comparing ethnic groups with distinct physical proportions, the absolute size of the dense areas appears to be a better measure of breast cancer risk than the relative density. © 2002 Wiley-Liss, Inc. Key words: mammographic density; Japan; Hawaii; breast cancer; mammogramBreast cancer incidence among women in Japan is much lower than among women of Japanese ancestry living in the United States. Age-adjusted (to the world standard population) incidence rates were 30.8 cases/100,000 in Japan 1 compared to 78.3 and 97.1 cases/100,000 among women of Japanese and Caucasian ancestry in Hawaii, respectively (unpublished report for 1990 -1992 from the Hawaii Tumor Registry). Reasons for the discrepant breast cancer rates are not well understood, but the fact that risk in migrants increases over 2 or 3 generations 2,3 suggests that environmental factors, including diet, 4 may be determinants of risk in addition to the well-established reproductive factors, adult adiposity, weight change and height. 5 Mammographic density patterns, which refer to the distribution of fat, connective and epithelial tissue in the healthy female breast, have been related to breast cancer risk. 6 A high percentage of dense parenchyma on mammographic images appears to confer a 4-fold risk of developing breast cancer. 7 Immigration from Japan to Hawaii occurred primarily during 1868 -1924, 8 when more than 200,000 Japanese came to Hawaii. We hypothesized that Japanese women in Hawaii are more likely to have a dense parenchymal pattern than women in Japan. The primary objective of our cross-sectional study was to compare mammographic density charact...

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“…The risk of breast cancer among nonwhite women is consistently lower than that of white women and, overall, ethnic differences in mammographic density have been found to be consistent with those for breast cancer risk [7][8][9] with the exception of one study that reported mammographic density was higher in less acculturated Asian women [10].…”

Section: Introductionmentioning

confidence: 79%

Genetic influences on mammographic density in Korean twin and family: the Healthy Twin study

Sung

Song

Stone

et al. 2010

Breast Cancer Res Treat

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Higher mammographic density is a strong risk factor for breast cancer. This study was conducted to determine the role of genetic factors on mammographic density measurements in Korean women. Study subjects were 730 women (122 monozygotic (MZ) twin pairs, 28 dizygotic (DZ) twin pairs, and 430 first degree relatives) from the Healthy Twin study. Mammographic density was measured using a computer-assisted method. Pairwise correlations of residual variance of each component of mammographic density were calculated within each pair of twins and family members. Quantitative genetic analysis was completed using SOLAR. Age and measured covariates accounted for 50% of the variation in dense area, 70% of non-dense area, and 67% of percent dense area. Fully adjusted heritability coefficients for dense area, non-dense area, and percent dense area were 0.76 (SE = 0.04), 0.69 (SE = 0.04) and 0.68 (SE = 0.04), respectively. Pairwise correlation coefficients of the adjusted residual variance of the mammographic density measures within MZ pairs and within DZ and sibling pairs combined were, respectively, 0.70 and 0.28 for dense area, 0.52 and 0.31 for non-dense area, and 0.58 and 0.24 for percent dense area. Covariance between dense and non-dense area had a significant genetic basis (correlation coefficient = -0.25, SE = 0.06). The same high heritability of mammographic density in Korean women as found in Western women supports a significant role of genetic determinants in breast cancer development. Genes that are responsible for familial correlation in mammographic density and have opposite effects on dense and non-dense mammographic areas need to be elucidated.

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A comparison of mammographic parenchymal patterns in premenopausal Japanese and British women

Abstract: Normal premenopausal Japanese women have significantly more favourable mammographic parenchymal patterns (Wolfe Grades) than comparable British women. This finding is unaffected when the women are stratified by age, Quetelet's Index, age at menarche, age at first birth, and parity.

Cited by 16 publications

References 14 publications

Age‐ and race‐dependence of the fibroglandular breast density analyzed on 3D MRI

Age‐ and race‐dependence of the fibroglandular breast density analyzed on 3D MRI

Comparison of mammographic densities and their determinants in women from Japan and Hawaii

Genetic influences on mammographic density in Korean twin and family: the Healthy Twin study

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