This chapter presents a practical methodology for characterizing and propagating the effects of temperature-dependent material strength and failure-criteria variability to structural model predictions. The application involves a cylindrical canister ("can") heated and pressurized to failure. Temperature dependence and material sample-to-sample stochastic variability are inferred from very limited experimental data of a few replicate uniaxial tension tests at each of seven temperatures spanning the 800°C temperature excursion experienced by the can, for each of several stainless steel alloys that make up the can. The load-displacement curves from the material tests are used to determine effective temperature-dependent stress-strain relationships in ductile-metal plasticity models used in can-level model predictions. Particularly challenging aspects of the problem are the appropriate inference, representation, and propagation of temperature dependence and material stochastic variability from just a few experimental data curves at a few temperatures (as sparse discrete realizations or samples from a random field of temperature-dependent stress-strain behavior), for multiple such materials involved in the problem. Currently unique methods are demonstrated that are relatively simple and effective. 1 references [1-7] describes aspects of the associated activities, including experiments, modeling and simulation, code and calculation verification, and advanced model validation and uncertainty quantification (UQ) methods.The modeling and verification, validation, and uncertainty quantification (VVUQ) activities were performed under a multiyear "abnormal thermalmechanical breach" (T-M breach) task [1] of a Predictive Capability Assessment Project (PCAP) in the Verification & Validation (V&V) subelement of the U.S. Dept. of Energy Advanced Simulation and Computing (ASC) program. The goal of the PCAP T-M breach task was to assess the error and quantify the uncertainty in modeling the thermal-chemical-mechanical response and weld-related breach failure of sealed canisters ("cans") weakened by high temperatures and pressurized by heat-induced pyrolysis of foam. The planned outcome of the PCAP T-M breach task was to measure improvements in prediction accuracy over time as the models and computer platforms became more capable.The Sandia Weapon System Engineering and Assessment Technology Campaign (WSEAT) program supported the project by conducting material characterization tests and validation experiments [2] (see Figure 1). This partnership provided an opportunity to develop a fully integrated process from design of experiments through model validation assessment, with uncertainty reduced as much as possible and propagated through the process.Breach failures were expected to occur, and in the tests, they did occur, at the circumferential perimeter (laser) weld that joins the top lid to the can sidewalls. This is because the weld thickness is significantly less than the can lid and sidewalls (see Figure 2), and the tests/cans of...