A comparison of methylphenidate induced active avoidance and water maze performance facilitation

Kinney, Lois; Vorhees, Charles V.

doi:10.1016/0091-3057(79)90210-7

Cited by 16 publications

(3 citation statements)

References 10 publications

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“…Across regimens, MA led to reduction in locomotor activity but faster swimming on the reversal and shift phases of the MWM. Swimming behavior has previously been shown to be immune from changes in land‐based locomotor activity (Cravens, 1974) except at the extremes (Kinney and Vorhees, 1979). An extensive literature showing that rats with hippocampal lesions (known to induce locomotor hyperactivity) and acute stimulant treatments that increase locomotor activity simultaneously induce impaired learning in the MWM (Brandeis et al, 1989).…”

Section: Discussionmentioning

confidence: 99%

Effects of (+)‐methamphetamine on path integration and spatial learning, but not locomotor activity or acoustic startle, align with the stress hyporesponsive period in rats

Vorhees

Skelton

Grace

et al. 2008

Intl J of Devlp Neuroscience

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Rats treated with (+)-methamphetamine (MA) on postnatal (P) days 11−20 exhibit long-term spatial and path integration (Morris and Cincinnati water mazes) learning deficits whereas those treated on P1−10 do not. MA-treatment increases corticosterone release in an age-dependent U-shaped pattern that corresponds to the stress hyporesponsive period (SHRP; P4−15). Here we tested the hypothesis that the cognitive effects induced by MA are associated with treatment that begins within the SHRP. Three treatment regimens were compared, P1−10, 6−15, and 11−20. One male/female pair/litter received 0, 10, or 25 mg/kg MA/dose (4 doses/day at 2 h intervals given s.c. with 19−21 litters/ regimen). Locomotor activity and acoustic startle were tested as behaviors not predicted to be associated with the SHRP. Cincinnati and Morris water maze findings were consistent with the hypothesis in that MA-treated animals exposed from P6−15 or P11−20 showed impaired learning compared to those exposed from P1−10; however, on probe trials in the Morris water maze, MAinduced memory impairments were not regimen-specific and were contributed to by all treatment regimens. All MA treatment regimens induced reductions in locomotor activity and acoustic startle facilitation as expected. No differential effect on prepulse trials was seen suggesting no impairment in sensory gating. Cognitive deficits from neonatal MA treatment are associated with the SHRP and may be the product of hypothalamic-pituitary-adrenal axis dysregulation during critical periods of brain development.

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Section: Discussionmentioning

confidence: 99%

Effects of (+)‐methamphetamine on path integration and spatial learning, but not locomotor activity or acoustic startle, align with the stress hyporesponsive period in rats

Vorhees

Skelton

Grace

et al. 2008

Intl J of Devlp Neuroscience

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“…Nevertheless, the maze continued to be effective at differentiating treatment-related effects of various independent variables, but there were also treatments that did not cause changes in learning on the task. One study showed that high acute doses of methylphenidate enhanced performance by increasing swim speed so much that latency and errors to find the goal were reduced (Kinney and Vorhees, 1979). No effect findings occurred after prenatal exposure to prochlorperazine, fenfluramine, or propoxyphene (Vorhees et al, 1979).…”

Section: Assessing Navigation In Rodentsmentioning

confidence: 99%

Cincinnati water maze: A review of the development, methods, and evidence as a test of egocentric learning and memory

Vorhees¹,

Williams²

2016

Neurotoxicology and Teratology

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Advantageous maneuvering through the environment to find food and avoid or escape danger is central to survival of most animal species. The ability to do so depends on learning and remembering different locations, especially home-base. This capacity is encoded in the brain by two systems: one using cues outside the organism (distal cues), allocentric navigation, and one using self-movement, internal cues (proximal cues), for egocentric navigation. Whereas allocentric navigation involves the hippocampus, entorhinal cortex, and surrounding structures, egocentric navigation involves the dorsal striatum and connected structures; in humans this system encodes routes and integrated paths and when over-learned, becomes procedural memory. Allocentric assessment methods have been extensively reviewed elsewhere. The purpose of this paper is to review one specific method for assessing egocentric, route-based navigation in rats: the Cincinnati Water Maze (CWM). The test is an asymmetric multiple-T maze arranged in such a way that rats must learn to find path openings along walls rather at ends in order to reach the goal. Failing to do this leads to cul-de-sacs and repeated errors. The task may be learned in the light or dark, but in the dark, wherein distal cues are eliminated, provides the best assessment of egocentric navigation. When used in conjunction with tests of other types of learning, such as allocentric navigation, the CWM provides a balanced approach to assessing the two major forms of navigational learning and memory found in mammals.

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“…Increasingly, MPH is being used both on and off-label to specifically improve long-term memory (LTM) [2][3][4]. Few studies, however, have examined MPH's ability to modulate spatial or long-term memory [5][6][7]. Rather, most research has focused on MPH-induced improvements in working memory, attention, and cognitive control [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Methylphenidate enhances acquisition and retention of spatial memory

Carmack¹,

Block²,

Howell³

et al. 2014

Neuroscience Letters

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h i g h l i g h t s• 10 mg/kg MPH given pre-training enhances learning on the hidden platform version of the Morris water maze.• 1 or 10 mg/kg MPH given pre-training enhances retention of spatial memory in the water maze.• 10 mg/kg MPH given chronically before Pavlovian fear conditioning dramatically impairs long-term fear memory. Psychostimulants containing methylphenidate (MPH) are increasingly being used both on and off-label to enhance learning and memory. Still, almost no studies have investigated MPH's ability to specifically improve spatial or long-term memory. Here we examined the effect of training with 1 or 10 mg/kg MPH on hidden platform learning in the Morris water maze. 10 mg/kg MPH improved memory acquisition and retention, while 1 mg/kg MPH improved memory retention. Taken together with prior evidence that low, clinically relevant, doses of MPH (0.01-1 mg/kg MPH) enhance fear memory we conclude that MPH broadly enhances memory. a r t i c l e i n f o

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A comparison of methylphenidate induced active avoidance and water maze performance facilitation

Cited by 16 publications

References 10 publications

Effects of (+)‐methamphetamine on path integration and spatial learning, but not locomotor activity or acoustic startle, align with the stress hyporesponsive period in rats

Effects of (+)‐methamphetamine on path integration and spatial learning, but not locomotor activity or acoustic startle, align with the stress hyporesponsive period in rats

Cincinnati water maze: A review of the development, methods, and evidence as a test of egocentric learning and memory

Methylphenidate enhances acquisition and retention of spatial memory

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