The aim of this study was to assess the tensile bond strength of four adhesive systems to enamel and dentin: Clearfil Liner Bond 2V -C, Prime&Bond NT/NRC -PB, Single Bond -SB and All Bond 2 -AB. For such purpose, 40 sound human molars were selected. Crowns were bisected in a mesiodistal direction and each half was ground until flat enamel (E) or dentin (D) surfaces were obtained. A total of 80 specimens were randomly assigned to 4 groups (n=20, 10 in enamel and 10 in dentin). After surface treatment, a composite resin (Z250; 3M) cone was prepared using a split Teflon ® matrix. Bond strength was tested in an universal testing machine (0. . Statistical analysis of data by two-way ANOVA showed that C presented the best results followed by SB. In conclusion, among the tested materials, Clearfil Liner Bond 2V self-etching primer adhesive syetem had the best performance. The substrate type influenced bond strength, being higher to enamel.