2017
DOI: 10.1097/dss.0000000000000910
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A Comparison of Mohs Micrographic Surgery and Wide Local Excision for Treatment of Dermatofibrosarcoma Protuberans With Long-Term Follow-up: The Mayo Clinic Experience

Abstract: Surgical excision with meticulous histologic evaluation of all surgical margins is needed for DFSP treatment to achieve long-term high cure rates and low morbidity.

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Cited by 101 publications
(112 citation statements)
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“…Complete micrographic control of excisional margins, for example using 3D‐histology, should be attempted, especially following tumor removal with narrow surgical margins. Studies conducted in the US comparing Mohs micrographic surgery (MMS) with generous local excision have shown a lower recurrence risk for MMS .…”
Section: Dermatofibrosarcoma Protuberansmentioning
confidence: 99%
See 1 more Smart Citation
“…Complete micrographic control of excisional margins, for example using 3D‐histology, should be attempted, especially following tumor removal with narrow surgical margins. Studies conducted in the US comparing Mohs micrographic surgery (MMS) with generous local excision have shown a lower recurrence risk for MMS .…”
Section: Dermatofibrosarcoma Protuberansmentioning
confidence: 99%
“…Molekulargenetische Untersuchungen ermöglichten in den letzten Jahren nicht nur ein besseres Verständnis der Pathogenese auf molekularer Ebene, sondern konnten auch neue, therapeutische Zielstrukturen identifi zieren. [ 5 ] . DFSP, die aufgrund ihrer Ausdehnung und/oder anatomischen Lokalisation nicht oder nur unvollständig resezierbar sind oder die mehrfach rezidivieren, können einer Strahlentherapie zugeführt werden.…”
Section: Introductionunclassified
“…Eine lückenlose Schnittrandkontrolle, beispielsweise durch 3D‐Histologie, sollte vor allem bei geringen Sicherheitsabständen angestrebt werden. Im amerikanischen Sprachraum weisen Studien, die die intraoperative Schnittrandkontrolle (Moh‘s micrographic surgery; MMS) mit großzügiger Lokalexzision verglichen haben, auf eine geringeres Rezidivrisiko unter MMS hin .…”
Section: Therapieunclassified
“…DFSP is a tumor of intermediate malignancy with low metastatic potential, but locally aggressive behavior. Historically, recurrence rates are reported to be as high as 50%; however, more recent studies show an overall recurrence rate of 7.3% . The presence of fibrosarcomatous areas indicates a more aggressive behavior with higher potential for metastasis .…”
Section: Introductionmentioning
confidence: 99%