A comparison of omeprazole and ranitidine in the prevention of recurrence of benign esophageal stricture

Smith, Paul M.; Kerr, G. D.; Cockel, R.; Ross, Barry; Bate, C. M.; Brown, Paul E.; Dronfield, M W; Green, Jonathan R.B.; Hislop, W.S.; Theodossi, A; Rj, McFarland; Watts, Deborah A; Taylor, Michael D.; Richardson, P. D.

doi:10.1016/0016-5085(94)90532-0

Cited by 195 publications

(69 citation statements)

References 14 publications

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“…A stricture elsewhere should raise suspicion for another etiology. PPIs are clearly superior to H 2 -receptor antagonists and when used in a maintenance fashion improve dysphagia, decrease the need for repetitive dilations and / or prolong the interval between dilations ( 171,172 ).…”

Section: Summary Of the Evidencementioning

confidence: 99%

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Katz¹,

Gerson²,

Vela³

2013

American Journal of Gastroenterology

1,554

1,430

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Section: Summary Of the Evidencementioning

confidence: 99%

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Katz¹,

Gerson²,

Vela³

2013

American Journal of Gastroenterology

1,554

1,430

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“…Furthermore, use of omeprazole instead of H2-receptor antagonists may be useful. 19 In our experience, this complication remains apparently without consequence for the outcome of BMT as long as the diagnosis is made early enough before severe malnutrition occurs. Despite the high probability of these patients developing secondary carcinoma of the oral and pharyngeal mucosa after BMT, 20 none of the lesions we observed showed signs of malignant transformation but this stresses the importance of careful longterm follow-up of these patients and the advisability of performing endoscopies and biopsies as soon as symptoms occur.…”

Section: Discussionmentioning

confidence: 78%

Severe oesophagitis after allogeneic bone marrow transplantation for Fanconi's anemia

Yakoub-Agha

Damaj

Garderet

et al. 2000

Bone Marrow Transplant

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Summary:Allogeneic bone marrow transplantation (BMT) is an effective treatment for Fanconi's anemia (FA) but it requires a dose reduction of alkylating agents used for conditioning because of the increased sensitivity of FA cells to DNA cross-linking agents. Oesophageal damage has not previously been described as a complication after allogeneic BMT for this indication. We report five cases of severe oesophagitis with stenosis in patients transplanted for FA. It occurred either early, or more surprisingly, several years after BMT and could have easily been misdiagnosed. It could be explained by hypersensitivity of the FA mucosal cells to cytotoxic agents despite the reduced doses of cyclophosphamide and irradiation or to non diagnosed congenital abnormalities of the oesophagogastric junction. However, the evolution of the oesophageal disease was favorable in all, and none of the patients developed secondary cancer. Awareness of this complication will lead to earlier diagnosis and treatment of oesophageal stenosis and related malnutrition. Bone Marrow Transplantation (2000) 26, 215-218.

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“…It has also been shown by Smith et al [31]that omeprazole 20 mg once daily is better than ranitidine 150 mg twice daily in maintaining patients with strictures free from symptoms (65% and 43% of patients maintained, respectively). In another randomized trial, Swarbrick et al [32]have shown that lansoprazole 30 mg once daily resulted in fewer dilatations and a higher proportion of dysphagia-free patients than high-dose ranitidine (300 mg twice daily).…”

Section: Prevention Of Oesophageal Ulcers and Stricturesmentioning

confidence: 86%

Optimizing Symptom Relief and Preventing Complications in Adults with Gastro-Oesophageal Reflux Disease

Savarino¹,

Dulbecco²

2004

Digestion

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Gastro-oesophageal reflux disease (GORD) is a chronic illness causing recurrent typical and atypical symptoms. Possible complications include oesophagitis, ulcer, stricture and Barrett’s oesophagus. Evidence suggests that the intraoesophageal pH correlates directly with the degree of mucosal injury. Proton pump inhibitors (PPIs) are the first choice of therapy because they are significantly more effective than histamine-2-receptor antagonists (H₂RAs) in achieving and sustaining an intragastric pH above 4.0. Numerous trials have shown that PPIs provide superior and faster relief of heartburn compared with H₂RAs. PPIs have also been shown to be superior to H₂RAs in healing oesophageal ulcers and improving the clinical outcome of patients with stricture formation. Unfortunately, even higher-than-standard doses of PPIs do not provide a complete regression in the length of Barrett’s oesophagus, which is the most serious complication of GORD. Although the majority of patients with oesophagitis relapse within 6 months of stopping PPI therapy, maintenance PPI therapy prevents this in more than 80% of cases. Surgical and endoscopic procedures are alternative approaches to managing GORD. Surgery is successful but is not without risk. Endoscopic procedures are promising, but comparative and longer-term efficacy and safety data are needed.

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A comparison of omeprazole and ranitidine in the prevention of recurrence of benign esophageal stricture

Cited by 195 publications

References 14 publications

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease

Severe oesophagitis after allogeneic bone marrow transplantation for Fanconi's anemia

Optimizing Symptom Relief and Preventing Complications in Adults with Gastro-Oesophageal Reflux Disease

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