A comparison of outcomes for patients with oral squamous cell carcinoma at intermediate risk of recurrence treated by surgery alone or with post-operative radiotherapy

Brown, James S.; Blackburn, Thomas R.; Woolgar, Julia A.; Lowe, Derek; Errington, R.D.; Vaughan, E.D.; Rogers, Simon N.

doi:10.1016/j.oraloncology.2006.09.010

Cited by 67 publications

(48 citation statements)

References 25 publications

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“…Considering the results of CRT and adjunctive therapy, these results indicate that sensitivity to radiation and to anticancer drugs might be low in oral cancers, excluding tongue cancer, among Japanese patients. The performance of POCRT for the high-risk group has been recommended (Cooper et al 2004;Bernier et al 2004) and PORT alone for the moderate risk group according to NCCN Clinical Practice Guidelines for head and neck cancers, but the utility of post-operative treatment in oral cancer remains controversial (Sadeghi et al 1986;Inagi et al 2002;Brown et al 2007). Our results also indicate that a curative operation with a wide resection of the primary tumor may play an important role in achieving prognostic improvements.…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment Is Recommended for Advanced Oral Squamous Cell Carcinoma

Ogawa

Matsuura

Shiga

et al. 2011

Tohoku J. Exp. Med.

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Oral squamous cell carcinoma is one of the most frequent types of head and neck cancers in Japan. Although recent reports have shown positive results of non-surgical treatment for advanced head and neck squamous cell carcinoma, including tongue cancer, no clear treatment strategies have been established for oral cancers, except for tongue cancer. To assess appropriate therapies, we conducted a retrospective chart review of 114 Japanese patients with oral cancers that were pathologically diagnosed as squamous cell carcinoma, excluding tongue cancers. The overall and the disease specific 5-year survival rates were 53% and 61%, respectively. Univariate and multivariate analyses revealed a lower stage (I, II, or III) and non-surgical treatment as good and poor prognostic factors of oral squamous cell carcinoma, respectively, based on their hazard ratios of 0.17 (95% CI 0.045-0.60, p = 0.0061) and 5.3 (95% CI 2.7-11, p < 0.0001). Furthermore, impact of surgery was well documented in the operable stage IVa cancers (p = 0.00015). The surgical treatment consisted of the wide resection of the primary tumor and the neck dissection for stage III or IV tumors. The present data also suggest that adjunctive therapy, such as post-operative radiation therapy or post-operative chemo-radiation therapy, shows no survival benefit compared to the surgery alone. We therefore recommend the surgical treatment for advanced oral squamous cell carcinoma in Japanese patients. These results would be helpful in future clinical trials, especially in non-surgical treatment studies of oral squamous cell carcinoma in Japan.

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Section: Discussionmentioning

confidence: 99%

Surgical Treatment Is Recommended for Advanced Oral Squamous Cell Carcinoma

Ogawa

Matsuura

Shiga

et al. 2011

Tohoku J. Exp. Med.

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“…This examines the morphology, degree of differentiation and number of mitoses present in the sample. Along with histology, the size of tumour, lymph node involvement, perineural invasion vascular invasion and distant metastases are taken into account in order to tailor treatment and decide on adjuvant therapy [1]. These factors are used as predictors for 'aggressiveness' of the tumour and likelihood of recurrence.…”

Section: Introductionmentioning

confidence: 99%

“…These factors are used as predictors for 'aggressiveness' of the tumour and likelihood of recurrence. The recurrence of a tumour at the resection margins in HNSCC has profound implications on the morbidity and mortality of the patient [1]. Previous studies have predicted that a positive surgical margin is associated with at least doubled loco-regional recurrence and 5-year survival being almost halved [2].…”

Section: Introductionmentioning

confidence: 99%

The role of molecular strategies in the evaluation of surgical margins in oropharyngeal squamous cell carcinoma

et al. 2009

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The recurrence of a tumour at the resection margins in head and neck squamous cell carcinoma (HNSCC) has profound implications on the morbidity and mortality of the patient. At present HNSCC does not undergo any form of molecular analysis to aid treatment strategy and prognosticate for those individuals at higher risk of recurrence. This article aims to review current research into molecular strategies for tumour evaluation, highlighting conflicting evidence and possible novel concepts for further exploration.

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“…3 Furthermore, five-year crude survival rates are around 73% for pathological T1/T2 tumours (less than 4 cm) compared with 56% for T3/T4 tumours. 4 Exactly why such a high proportion of patients present with advanced disease is not fully understood. However, the longest delay in the cancer journey is due to patient delay prior to presentation.…”

Section: Introductionmentioning

confidence: 99%

A Survey of General Dental Practitioners in Merseyside regarding Urgent Appointments and Suspected Cancer Referrals

Rogers

Glen

Robinson

et al. 2008

Primary Dental Care

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Access to dental care has been a high-profile issue over the past few years. This survey indicated that in Merseyside, just under half of the dentists who responded were willing to see new patients with urgent problems under the NHS. It is suggested that this difficulty in access, together with some reported delays in obtaining appointments and the methods of onward referral, may cause additional barriers to early detection of oral cancer, especially for those in the most at-risk groups, who are also very frequently hard to reach.

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A comparison of outcomes for patients with oral squamous cell carcinoma at intermediate risk of recurrence treated by surgery alone or with post-operative radiotherapy

Cited by 67 publications

References 25 publications

Surgical Treatment Is Recommended for Advanced Oral Squamous Cell Carcinoma

Surgical Treatment Is Recommended for Advanced Oral Squamous Cell Carcinoma

The role of molecular strategies in the evaluation of surgical margins in oropharyngeal squamous cell carcinoma

A Survey of General Dental Practitioners in Merseyside regarding Urgent Appointments and Suspected Cancer Referrals

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