Surgical Treatment Is Recommended for Advanced Oral Squamous Cell Carcinoma

Ogawa, Takenori; Matsuura, Kazuto; Shiga, Kiyoto; Tateda, Masaru; Katagiri, Ken; Kato, Kengo; Saijo, Shigeru; Kobayashi, Toshimitsu

doi:10.1620/tjem.223.17

Cited by 4 publications

(1 citation statement)

References 34 publications

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“…Also, there is high incidence of osteoradionecrosis which may be due the fact that disease is already involving bone (retromolar trigone, mandibular alveolus) is not amenable for only irradiation or chemoradiation without primary resection. So, surgery should be the main stay of treatment followed by chemoradiation [14]. The type of radiation (intensity-modulated radiotherapy (IMRT) or conventional RT) also affects the survival outcomes when used concurrently with CT as IMRT is more effective along with CT than conventional RT.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Multimodal Therapy in the Survival Outcomes of Advanced-Stage (Stage III–Stage IV) Oral Carcinoma Patients: An Institutional Experience in Asian Indian Population

Dhawan

Duggal

Bhullar

et al. 2017

J. Maxillofac. Oral Surg.

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Aim Primary ablative surgery followed by post-op radiotherapy (S-RT) remains the mainstay of treatment for stage IIIstage IV oral carcinoma. A retrospective analysis of survival rates of advanced-stage OSCC patients treated with multimodal therapies (S-RT or combined chemoradiation) was performed to analyse the outcome for patient survival and whether addition of adjuvant chemotherapy (S-CRT) improves survival. Materials and Methods Demographic, pathological, treatment and follow-up data of 128 patients were included in the study. Sixty-nine patients received S-RT, while 55 patients were opted for S-CRT. Overall survival, diseasespecific survival and disease-free survival were estimated with Kaplan-Meier analysis and compared between groups with Cox regression analysis. Results Survival was significantly influenced by the type of modality and regional spread of disease. S-CRT group had improved overall, disease-specific, disease-free and metastasis-free survival compared to S-RT group. A survival advantage of 10% was achieved in S-CRT group compared to S-RT group even in patients with extracapsular spread and perineural invasion. Conclusion Addition of adjuvant chemotherapy to S-RT improves survival outcomes in advanced OSCC, especially in patients with regional spread of disease.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Multimodal Therapy in the Survival Outcomes of Advanced-Stage (Stage III–Stage IV) Oral Carcinoma Patients: An Institutional Experience in Asian Indian Population

Dhawan

Duggal

Bhullar

et al. 2017

J. Maxillofac. Oral Surg.

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Assessment of oral cancer pain, anxiety, and quality of life of oral squamous cell carcinoma patients with invasive treatment procedure

Sjamsudin

Maulina

Cipta

et al. 2018

Oral Maxillofac Surg

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The development and validation of oral cancer staging using administrative health data

et al. 2014

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BackgroundOral cancer is a major global health problem. The complexity of histological prognosticators in oral cancer makes it difficult to compare the benefits of different treatment regimens. The Taiwanese National Health database provides an opportunity to assess correlations between outcome and treatment protocols and to compare the effects of different treatment regimens. However, the absence of indices of disease severity is a critical problem. The aim of this study was to ascertain how accurately we could assess the severity of oral cancer at the time of initial diagnosis on the basis of variables in a national database.MethodsIn the cancer registry database of a medical center in Taiwan, we identified 1067 histologically confirmed cases of oral cancer (ICD9 codes 140, 141 and 143–145) that had been first diagnosed and subjected to initial treatment in this hospital. The clinical staging status was considered as the gold standard and we used concordance (C)-statistics to assess the model’s predictive performance. We added the predictors of treatment modality, cancer subsite, and age group to our models.ResultsOur final overall model included treatment regimen, site, age, and two interaction terms; namely, interactions between treatment regimen and age and those between treatment regimen, site, and age. In this model, the C-statistics were 0.82–0.84 in male subjects and 0.96–0.99 in female subjects. Of the models stratified by age, the model that considered treatment regimen and site had the highest C-statistics for the interaction term, this value being greater than 0.80 in male subjects and 0.9 in female subjects.ConclusionIn this study, we found that adjusting for sex, age at first diagnosis, oral cancer subsite, and therapy regimen provided the best indicator of severity of oral cancer. Our findings provide a method for assessing cancer severity when information about staging is not available from a national health-related database.

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Surgical Treatment Is Recommended for Advanced Oral Squamous Cell Carcinoma

Cited by 4 publications

References 34 publications

Efficacy of Multimodal Therapy in the Survival Outcomes of Advanced-Stage (Stage III–Stage IV) Oral Carcinoma Patients: An Institutional Experience in Asian Indian Population

Efficacy of Multimodal Therapy in the Survival Outcomes of Advanced-Stage (Stage III–Stage IV) Oral Carcinoma Patients: An Institutional Experience in Asian Indian Population

Assessment of oral cancer pain, anxiety, and quality of life of oral squamous cell carcinoma patients with invasive treatment procedure

The development and validation of oral cancer staging using administrative health data

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