Efficacy of Multimodal Therapy in the Survival Outcomes of Advanced-Stage (Stage III–Stage IV) Oral Carcinoma Patients: An Institutional Experience in Asian Indian Population

Abstract

Aim Primary ablative surgery followed by post-op radiotherapy (S-RT) remains the mainstay of treatment for stage IIIstage IV oral carcinoma. A retrospective analysis of survival rates of advanced-stage OSCC patients treated with multimodal therapies (S-RT or combined chemoradiation) was performed to analyse the outcome for patient survival and whether addition of adjuvant chemotherapy (S-CRT) improves survival. Materials and Methods Demographic, pathological, treatment and follow-up data of 128 patients were included in the study. Sixty-nine patients received S-RT, while 55 patients were opted for S-CRT. Overall survival, diseasespecific survival and disease-free survival were estimated with Kaplan-Meier analysis and compared between groups with Cox regression analysis. Results Survival was significantly influenced by the type of modality and regional spread of disease. S-CRT group had improved overall, disease-specific, disease-free and metastasis-free survival compared to S-RT group. A survival advantage of 10% was achieved in S-CRT group compared to S-RT group even in patients with extracapsular spread and perineural invasion. Conclusion Addition of adjuvant chemotherapy to S-RT improves survival outcomes in advanced OSCC, especially in patients with regional spread of disease.

Gold nanomaterials for oral cancer diagnosis and therapy: Advances, challenges, and prospects

“…In our previous study, we reported AuNRs were synthesized in the cavity of hollow silica nanoparticles to construct rattle-structured rough nanocapsules, which were used for complementary gene/chemo/photo therapy and play a high-efficiency anti-tumor effect [ 45 ]. Multimodal combination therapy has also been extensively studied in oral tumors [ [197] , [198] , [199] ]. AuNPs have become a promising platform for the diagnosis and treatment of nanomedicine with multiple therapeutic and diagnostic functions [ [200] , [201] , [202] , [203] ].…”