World Health Organization recognizes depression as one of the leading mental illnesses of public health concern, with estimated 300 million people affected. This study assessed the prevalence, pattern and risk factors associated with depression among women in rural areas of Sokoto state. A comparative cross-sectional study was carried out and using a multistage sampling technique, 383 respondents (monogamous 193, polygamous 185) were recruited into the study. A set of structured questionnaire was used to collect data which was analyzed using the Statistical Package for Social sciences (SPSS) version 23. The mean age of the respondents was 33.91±6.8 years in monogamous setting and 35.27±8.3 years in polygamous setting (t=1.189, p=0.235). In both settings, majority of the women were married (monogamous 92.2%, polygamous 89.2%, P>0.05) and all were Muslims. The overall prevalence of depression in both groups was 51.2% (n=197). With respect to family type, prevalence was higher among women in monogamous setting (54.2%) as compared to those from polygamous setting (49.7%) (P=0.578). In both groups, mild depression was the most common type of depression (43.1% among monogamous vs 54.3% among polygamous). Depressive symptoms experienced nearly everyday by respondents in both groups include feeling hopeless and down, having difficulty falling asleep and feeling tired. Significant predictors of depression were marital status and feeling sad for a long time. In conclusion, the overall prevalence of depression was high in this study and the prevalence was slightly higher in monogamous group than polygamous; most respondents in both groups had mild depression. Significant predictors of depression include marital status and being sad for long time. There is need for government health agencies and other partners to strengthen mental health services at community levels to enable early detection and proper management of depression among couples.