A comparison of susceptibility to five antifungal agents of yeast cultures from burn patients

Still, Joseph M.; Law, Edward; Belcher, Keith; Spencer, Sanjae

doi:10.1016/0305-4179(95)80002-6

Cited by 14 publications

(5 citation statements)

References 10 publications

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“…46,47 E. coli is generally considered to be a good model Gram-negative organism to test PDT because it is midway in susceptibility between the easy to kill Hemophilus and the difficult to kill Pseudomonas. C. albicans is increasingly found in nocosomial infections in burns 48 and to a lesser extent in surgical wounds. 49 When evaluated against these prototypical cell types, EtNBSe (3) was found to be a highly effective, broad-spectrum antimicrobial PDT drug.…”

Section: Discussionmentioning

confidence: 99%

“…Although E. coli is generally thought of as an intestinal or urinary tract pathogen, there is increasing concern about its presence in wound infections, and its ability to develop extended spectrum beta-lactamase resistance is causing increased international concern. , E. coli is generally considered to be a good model Gram-negative organism to test PDT because it is midway in susceptibility between the easy to kill Hemophilus and the difficult to kill Pseudomonas . C. albicans is increasingly found in nocosomial infections in burns and to a lesser extent in surgical wounds …”

Section: Discussionmentioning

confidence: 99%

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Synthesis and Properties of Benzo[a]phenoxazinium Chalcogen Analogues as Novel Broad-Spectrum Antimicrobial Photosensitizers

et al. 2006

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The goal of this investigation was to develop improved photosensitizers for use as antimicrobial drugs in photodynamic therapy of localized infections. Replacement of the oxygen atom in 5-(ethylamino)-9-diethylaminobenzo[a]phenoxazinium chloride (1) with sulfur and selenium afforded thiazinium and selenazinium analogues 2 and 3, respectively. All three dyes are water soluble, lipophilic, and red light absorbers. The relative photodynamic activities of the chalcogen series were evaluated against a panel of prototypical pathogenic microorganisms: the Gram-positive Enterococcus faecalis, the Gram-negative Escherichia coli, and the fungus Candida albicans. Selenium dye 3 was highly effective as a broad-spectrum antimicrobial photosensitizer with fluences of 4-32 J/cm2 killing 2-5 more logs of all cell types than sulfur dye 2, which was slightly more effective than oxygen analogue 1. These data, taken with the findings of uptake and retention studies, suggest that the superior activity of selenium derivative 3 can be attributed to its much higher triplet quantum yield.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Synthesis and Properties of Benzo[a]phenoxazinium Chalcogen Analogues as Novel Broad-Spectrum Antimicrobial Photosensitizers

et al. 2006

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Section: Discussionmentioning

confidence: 99%

“…Under these circumstances, appropriate fungal and bacterial investigations (skin scrapings, fecal analysis, and bacterial cultures) are imperative to select the best therapeutic approach. 12 The efficacy of mupirocin in cutaneous candidosis has been established with the eradication of all Candida organisms within 2-5 days with rapid healing of exudative excoriated wounds. 5 In addition, mupirocin is an antibacterial agent with a wide range of activity against both Gram-positive and Gram-negative aerobic and anaerobic bacteria.…”

Section: Discussionmentioning

confidence: 99%

Perianal candidosis—a comparative study with mupirocin and nystatin

et al. 1999

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“…The classic presentation is black deposits over the burn raw area appearing spontaneously in previously healing wounds[ 2 ]. Patients with larger surface area burns are at higher risk for acquiring such infections[ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Angioinvasive mucormycosis in burn intensive care units: A case report and review of literature

Parashar,

Singh

2024

World J Crit Care Med

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BACKGROUND Mucormycosis is a rare, rapidly progressive and often fatal fungal infection. The rarity of the condition lends itself to unfamiliarity, delayed treatment, and poor outcomes. Diagnosis of fungal infections early enough to enable appropriate treatment occurs in less than half of affected patients. CASE SUMMARY An 11-year-old girl with a history of 15% total body surface area scald burns involving both lower limbs progressed to develop angioinvasive mucormycosis. This further led to a thrombosis of the right external iliac artery and vein and rapidly progressive necrosis of surrounding soft tissues. She also had dextrocardia and patent foramen ovale. A right hip disarticulation and serial aggressive debridements were performed but she went on to develop systemic sepsis with multisystem involvement and succumbed to the infection. Pathology revealed mucor species with extensive vascular invasion. CONCLUSION This case highlights the importance of maintaining vigilance for mycotic infections and acting appropriately when there are signs of fulminant wound infection.

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A comparison of susceptibility to five antifungal agents of yeast cultures from burn patients

Cited by 14 publications

References 10 publications

Synthesis and Properties of Benzo[a]phenoxazinium Chalcogen Analogues as Novel Broad-Spectrum Antimicrobial Photosensitizers

Synthesis and Properties of Benzo[a]phenoxazinium Chalcogen Analogues as Novel Broad-Spectrum Antimicrobial Photosensitizers

Perianal candidosis—a comparative study with mupirocin and nystatin

Angioinvasive mucormycosis in burn intensive care units: A case report and review of literature

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