Perianal candidosis—a comparative study with mupirocin and nystatin

Wet, P. M. De; Rode, H.; Dyk, A. Van; Millar, A. J. W.

doi:10.1046/j.1365-4362.1999.00757.x

Cited by 31 publications

(24 citation statements)

References 13 publications

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“…After 14 days of treatment, however, clinical cure rates were significantly higher with clotrimazole (68.1%) than with nystatin (46.9%, P < 0.05). The comparative efficacy and safety of nystatin in DD were assessed on several occasions in the past 14,15 . Clinical cure rates at day 14 were higher with both agents in our study than those reported for miconazole nitrate, where overall cure rates (clinical cure plus microbiologic cure) of only 23% were reported; only 10% of the control group (zinc oxide/petrolatum) improved ( P = 0.005).…”

Section: Discussioncontrasting

confidence: 53%

Efficacy and safety of two different antifungal pastes in infants with diaper dermatitis: a randomized, controlled study

Hoeger

Stark

Jost

2010

Acad Dermatol Venereol

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Section: Discussioncontrasting

confidence: 53%

Efficacy and safety of two different antifungal pastes in infants with diaper dermatitis: a randomized, controlled study

Hoeger

Stark

Jost

2010

Acad Dermatol Venereol

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“…To treat angular cheilitis caused by overclosure, petrolatum or lip balm can be used as a mechanical barrier. In cases associated with bacteria, topical mupirocin 2% ointment three to four times daily until resolution can be helpful (36). Angular cheilitis resulting from deep orofacial grooves may be amenable to soft tissue augmentation with fillers at the oral commissures to correct the anatomic defect (37).…”

Section: Angular Cheilitismentioning

confidence: 99%

Oral candidiasis and angular cheilitis

Sharon

Fazel

2010

Dermatologic Therapy

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Candidiasis, an often encountered oral disease, has been increasing in frequency. Most commonly caused by the overgrowth of Candida albicans, oral candidiasis can be divided into several categories including acute and chronic forms, and angular cheilitis. Risk factors for the development of oral candidiasis include immunosuppression, wearing of dentures, pharmacotherapeutics, smoking, infancy and old age, endocrine dysfunction, and decreased salivation. Oral candidiasis may be asymptomatic. More frequently, however, it is physically uncomfortable, and the patient may complain of burning mouth, dysgeusia, dysphagia, anorexia, and weight loss, leading to nutritional deficiency and impaired quality of life. A plethora of antifungal treatments are available. The overall prognosis of oral candidiasis is good, and rarely is the condition life threatening with invasive or recalcitrant disease.

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“…Despite the importance of the nature and extent of microbial colonisation with regard to adequate treatment of diaper dermatitis, the scientific basis is weak, and many of the old studies are inadequate. Further studies to elucidate the microbiological basis of the disease are therefore warranted [15, 16]. …”

Section: Introductionmentioning

confidence: 99%

Microbiological Aspects of Diaper Dermatitis

Ferrazzini

Kaiser²,

Cheng

et al. 2003

Dermatology

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Background: The microbiological basis of diaper dermatitis is not clearly elucidated, although a better knowledge of microbial colonisation can be of importance with regard to an adequate treatment. Objective: To investigate the relevance of Candida sp. and Staphylococcus aureus colonisation in diaper dermatitis and to determine the correlation between the extent of colonisation and the severity of disease. Methods: Growth of Candida sp. and S. aureus in the perianal, inguinal and oral regions was determined by positive/negative and semi-quantitative analysis in an open, multi-centre (n = 3) study. Forty-eight children with healthy skin and 28 with diaper dermatitis were analysed. The severity of diaper dermatitis was assessed using a total symptoms score. Results: Colonisation by Candida sp. was significantly more frequent in children with diaper dermatitis as compared to those with healthy skin (perianal 75 vs. 19%; inguinal 50 vs. 10%; oral 68 vs. 25%, p < 0.0003), whereas colonisation by S. aureus at the 3 swab locations was not different (p > 0.34). There was a highly significant, positive correlation between severity of disease and extent of Candida sp. colonisation at all swab locations. Conclusions: Limited microbial colonisation in diaper dermatitis is of questionable relevance, but extensive colonisation seems to aggravate the symptoms; therefore, we suggest that semi-quantitative evaluation should be preferred to the positive/negative assessment for a differential diagnosis.

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Perianal candidosis—a comparative study with mupirocin and nystatin

Abstract: Both agents eradicated Candida, the major difference being the marked response of the diaper dermatitis to mupirocin. Mupirocin should be applied topically 3-4 times daily or with each diaper change and is an excellent antifungal agent.

Cited by 31 publications

References 13 publications

Efficacy and safety of two different antifungal pastes in infants with diaper dermatitis: a randomized, controlled study

Efficacy and safety of two different antifungal pastes in infants with diaper dermatitis: a randomized, controlled study

Oral candidiasis and angular cheilitis

Microbiological Aspects of Diaper Dermatitis

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