A comparison of the acute effects of radiation therapy, including or excluding the thymus, on the lymphocyte subpopulations of cancer patients.

Stratton, Joan A.; Byfield, Patricia; Byfield, John E.; Small, Richard C.; Benfield, John R.; Pilch, Yosef H.

doi:10.1172/jci108084

Cited by 99 publications

(40 citation statements)

References 32 publications

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“…The impaired response to PWM was not associated with any decrease in blood lymphocytes or B-cell levels, suggesting a qualitative disturbance of B-cell response to mitogen stimulation. Other studies have reported chronic depression of B-cell numbers and impaired PWM response in radiated cancer patients (31) or increased B-cell numbers (32,33) and normal PWM response (33) after RT of lymphoma.…”

Section: Discussionmentioning

confidence: 98%

Immune function of successfully treated lymphoma patients.

King¹,

Yanes²,

Hurtubise³

et al. 1976

J. Clin. Invest.

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A B S T R A C T Immunologic function was evaluated in 12 patients with Hodgkin's disease and 5 patients with lymphocytic lymphoma who had been successfully treated with either chemotherapy, radiation therapy, or both of these modalities 3-42 mo previously. Only two of the patients were found to have total anergy to a battery of six recall skin test antigens and all were responsive to skin testing with phytohemagglutinin. However, 10 of 16 patients were unable to develop delayed cutaneous hypersensitivity to either of the neoantigens dinitrochlorobenzene or keyhole limpet hemocyanin. Four other patients developed reactivity to only one of these neoantigens for a total of 14 of 16 (88%) of the patients demonstrating some impairment in neoantigen response.Total lymphocyte, T-lymphocyte, B-lymphocyte, and null cell numbers, as well as serum immunoglobulins were quantitatively normal. Monocyte numbers, chemotaxis, and Fc receptor activity were normal. Monocyte staphylocidal activity at 60 min was modestly depressed and candidacidal activity was depressed in those receiving both chemotherapy and radiation therapy.Spontaneous (unstimulated) lymphocyte [8H]thymidine incorporation was low in the patients as a group and lymphoblastic transformation to specific antigens was impaired in 11 of 17 patients who had positive skin test reactions to the same antigen. Highly significant suppression of lymphoblastic transformation was noted after stimulation by the mitogens phytohemagglutinin, pokeweed, and concanavalin-A. The greatest impairment of mitogen response was seen in those patients receiving both chemotherapy and radiation therapy.

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Section: Discussionmentioning

confidence: 98%

Immune function of successfully treated lymphoma patients.

King¹,

Yanes²,

Hurtubise³

et al. 1976

J. Clin. Invest.

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“…Radiation induced alterations in the number and function of peripheral blood lymphocytes have recently been described in patients treated with radiotherapy for carcinoma of the breast (1-6), lung (7)(8)(9), bladder (7)(8)(9)(10), uterine cervix (2,6,11). testicular seminoma and carcinoma (12.…”

Section: Introductionmentioning

confidence: 99%

“…However, at the completion of treatment, the mean total lymphocyte count of 503/mm3 was 4 SD below the mean for normal controls. Acute lymphocytopenia after a course of radiation has been described in a variety of clinical situations involving localized or extended field radiotherapy (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). Recovery usually begins shortly after completion of treatment (6,7,12), and continues through the next 1-2 yr.…”

Section: Introductionmentioning

confidence: 99%

Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease.

Fuks¹,

Strober²,

Bobrove³

et al. 1976

J. Clin. Invest.

269

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“…A differential rate of recovery of transformation to nonspecific mitogens has been observed in treated lymphoma patients (23,24) (23,24), and demonstrate that the recovery of normal numbers of T cells is not necessary for the recovery of lymphocyte transformation to the viral antigen. The recovery of PHA transformation did not parallel the return of transformation to the specific viral antigens closely enough to predict that viral cellular immunity would be present if PHA transformation was detectable.…”

Section: Cellular Itininunittx In Lyniphotna Patients Before Treatmentmentioning

confidence: 80%

Cellular and Humoral Immunity in the Pathogenesis of Recurrent Herpes Viral Infections in Patients with Lymphoma

Arvin¹,

Pollard²,

Rasmussen³

et al. 1980

J. Clin. Invest.

127

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A B S T R A C T 86 patients with lymphoma were evaluated prospectively for clinical and laboratory evidence ofrecurrent varicella-zoster, herpes simplex, and cytomegalovirus infections during the first 16 mo of treatment. Cellular immunity to the viral antigens was measured by in vitro lymphocyte transformation and interferon production. Antibody titers and nonspecific measures ofcellular immunity, including T-cell quantitation and transformation to phytohemagglutinin, were also assessed. The patients treated with radiation and chemotherapy had the highest incidence of reactivation of each of the viruses (15-19%). Greater susceptibility to herpes viral reactivation in these patients correlated with suppression of cell-mediated immunity to the specific virus. In individual patients, suppression of cellular immunity to the specific herpes viral antigen preceded each episode of reactivation, but recurrent infection did not occur in all patients with diminished specific lymphocyte transformation. Absence of the response appears to be a necessary but not a sufficient condition for the recrudescence of latent infection.Better preservation of cellular immnlunity to herpes simplex antigen during treatment was associated with infre(uent reactivation of herpes simplex. In 25 patients with acute herpes zoster, uncomplicated recovery from the infection was accompanied by the development of lymphocyte transformation and interferon production to varicella-zoster antigen. Quantitation of T-cell numbers and phytohemagglutinin transformation clid not correlate with the presence of viral cellular immunity in treated patients. Responses returned while T-cell numbers were low, and the The Abstract was presented at the Fourth Herpes Virus Meeting, Cold Spring Harbor, N. Y.

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A comparison of the acute effects of radiation therapy, including or excluding the thymus, on the lymphocyte subpopulations of cancer patients.

Cited by 99 publications

References 32 publications

Immune function of successfully treated lymphoma patients.

Immune function of successfully treated lymphoma patients.

Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease.

Cellular and Humoral Immunity in the Pathogenesis of Recurrent Herpes Viral Infections in Patients with Lymphoma

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