A Comparison of the ATP: L-Methionine-S-Adenosyltransferase of Rat Cerebral Cortex and Cerebellum

Abstract

The ATP: L-methionine-S-adenosyltransferase of rat cerebral cortex and cerebellum was found to be differentially responsive to solubilization by sodium deoxycholate. Furthermore, the cerebellar enzyme was markedly less sensitive to inactivation by deoxycholate and to storage at 4°C. The specific activity of the cerebellar enzyme was significantly higher and the two enzyme activities also exhibited differences in apparent K(m) values for L-methionine.