A comparison of the contractile activity fo PGD2 and PGF2α on human isolated bronchus

Modulation of eicosanoid-induced contraction of mouse and rat blood vessels by gingerols.

“…The order of potency of the prostanoids and LT was estimated to be LTs> (TXA2) > PG F2a > PGI2 Na > PG E2 > TR K-100 > PG D2 for mouse mesenteric vein. These responses were similar to those obtained for guinea pig lung (10) and isolated human bronchus (11). This suggests that the mouse mesenteric veins contain more than one type of eicosanoid re ceptor-mediating contraction.…”

BAY u3405 an antagonist of thromboxane A2‐ and prostaglandin D2‐induced bronchoconstriction in the guinea‐pig

“…The contractile activity of TXA2 and PGD2 on airway tissues is well documented (Coleman et al, 1980;Black et al, 1986;McKenniff et al, 1988;Giles & Leff, 1988). The metabolite of PGD2 (9a, 1 1fJ-PGF2) also has potent contractile activity on human and guinea-pig airways in vitro (Featherstone et al, 1990) and by inhalation in man (Beasley et al, 1987).…”

Prostanoid‐induced contraction of human bronchial smooth muscle is mediated by TP‐receptors

“…It is now well known that human isolated bronchial smooth muscle can contract in response to prostanoids (Strandberg & Hedqvist, 1977;Karim et al, 1980;Black et al, 1986;Seibert et al, 1987), and that not only PGF2g, but also PGD2 and the principle metabolite of PGD2, 9x,1lfi-PGF2(1 (l1-PGF2), all cause bronchoconstriction in man (Robinson et al, 1987). A preliminary investigation into the nature of the receptors mediating this effect has recently been reported by McKenniff et al (1988), who speculated that contraction of human Author for correspondence.…”