A comparison of the effects of temporary hippocampal lesions on single and dual context versions of the olfactory sequence memory task.

Sill, Orriana C.; Smith, David M.

doi:10.1037/a0028824

Cited by 7 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, using an incidental recognition task (visual paired-comparison or object/context-VPC), Bachevalier and colleagues (Bachevalier et al 2015) demonstrated a lack of novelty preference in monkeys with selective hippocampal lesions sustained in adulthood when a familiar object was presented over a new background. Similar findings have also been reported in humans, rabbits and rodents (Burgess et al 2001; Freeman et al 1997; Kennedy & Shapiro 2004; Kim & Fanselow 1992; Kim et al 2012; Mayes et al 1992; Smith & Mizumori 2006; Penick & Solomon 1991; Phillips & LeDoux 1992; Rudy et al 2002; Sill & Smith 2012; Pascalis et al 2009; Spiers et al 2001).…”

Section: Introductionsupporting

confidence: 88%

Neonatal hippocampal lesions facilitate biconditional contextual discrimination learning in monkeys.

Glavis-Bloom¹,

Bachevalier²

2018

Behavioral Neuroscience

View full text Add to dashboard Cite

This study examined whether selective neonatal hippocampal lesions in monkeys (Macaca mulatta), which left the surrounding cortical areas (parahippocampal cortex) intact, affect contextual learning and memory compared to controls. Monkeys were tested with an automated touch-screen apparatus so that stimuli and contextual cues could be manipulated independently of one another. The data suggest that animals with neonatal hippocampal lesions have sparing of function in regards to contextual learning and memory when (1) contextual information is irrelevant or (2) relevant for good discrimination performance, and (3) when transferring a contextual rule to new discriminations. These findings are at odds with studies examining contextual learning and memory in monkeys with selective adult-onset hippocampal lesions, and those with non-selective neonatal hippocampal lesions, which have demonstrated impairment in contextual learning and memory. Therefore, the sparing of function seen in this study may be due to the early nature of the damage and the plastic nature of the infant brain, as well as the intact medial temporal lobe cortical areas as a result of the lesion methodology. Specifically, by removing the hippocampus early in life, before it has begun to function, the parahippocampal (TH/TF) and perirhinal cortices and its interactions with the lateral prefrontal cortex may be able to support context processing throughout life.

show abstract

Section: Introductionsupporting

confidence: 88%

Neonatal hippocampal lesions facilitate biconditional contextual discrimination learning in monkeys.

Glavis-Bloom¹,

Bachevalier²

2018

Behavioral Neuroscience

View full text Add to dashboard Cite

show abstract

“…This is consistent with previous reports showing that ventral hippocampus has a role in processing nonspatial information (Bannerman et al, 2002; Kjelstrup et al, 2002) and is less critical for spatial learning and memory than dorsal hippocampus (de Hoz et al, 2003; Moser et al, 1993; Moser and Moser, 1998). There are a number of studies that have implicated the hippocampus in processing contextual information (Mumby et al, 2002a; Maren, 2008; Rudy, 2009; Sill and Smith, 2012). Our current data would suggest that these effects are most likely mediated through the LEC, DG, and ventral hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Lateral entorhinal cortex is critical for novel object‐context recognition

et al. 2013

View full text Add to dashboard Cite

Episodic memory incorporates information about specific events or occasions including spatial locations and the contextual features of the environment in which the event took place. It has been modeled in rats using spontaneous exploration of novel configurations of objects, their locations, and the contexts in which they are presented. While we have a detailed understanding of how spatial location is processed in the brain relatively little is known about where the nonspatial contextual components of episodic memory are processed. Initial experiments measured c-fos expression during an object-context recognition (OCR) task to examine which networks within the brain process contextual features of an event. Increased c-fos expression was found in the lateral entorhinal cortex (LEC; a major hippocampal afferent) during OCR relative to control conditions. In a subsequent experiment it was demonstrated that rats with lesions of LEC were unable to recognize object-context associations yet showed normal object recognition and normal context recognition. These data suggest that contextual features of the environment are integrated with object identity in LEC and demonstrate that recognition of such object-context associations requires the LEC. This is consistent with the suggestion that contextual features of an event are processed in LEC and that this information is combined with spatial information from medial entorhinal cortex to form episodic memory in the hippocampus. © 2013 Wiley Periodicals, Inc.

show abstract

“…A review of these studies is beyond the scope of this article but a number of findings are particularly relevant to the data presented here. The hippocampus has been shown to be necessary for complex associations of stimuli that may parallel OPC associations (Good et al, 2007 ; Sill and Smith, 2012 ). However, the hippocampus has also been implicated in associations that are possibly more basic (paralleling the OP/OC recognition tasks used here) such as learning odor-context associations for reward (Komorowski et al, 2009 ; Morris et al, 2013 ), object-context associations (Mumby, 2002 ; Piterkin et al, 2008 ) learning cue-context associations (Good et al, 1998 ; Honey and Good, 2000 ; Ainge et al, 2012 ), learning new odor-place (Gilbert and Kesner, 2002 ; Goodrich-Hunsaker et al, 2009 ) and object-place associations (Gaffan and Harrison, 1989 ; Parkinson et al, 1988 ; Sziklas et al, 1998 ; Bussey et al, 2000 ; Gilbert and Kesner, 2002 ; Crane and Milner, 2005 ; Lee and Solivan, 2010 ; Barker and Warburton, 2011 ) although see (Malkova and Mishkin, 2003 ).…”

Section: Discussionmentioning

confidence: 99%

Lateral entorhinal cortex is necessary for associative but not nonassociative recognition memory

et al. 2013

View full text Add to dashboard Cite

The lateral entorhinal cortex (LEC) provides one of the two major input pathways to the hippocampus and has been suggested to process the nonspatial contextual details of episodic memory. Combined with spatial information from the medial entorhinal cortex it is hypothesised that this contextual information is used to form an integrated spatially selective, context-specific response in the hippocampus that underlies episodic memory. Recently, we reported that the LEC is required for recognition of objects that have been experienced in a specific context (Wilson et al. (2013) Hippocampus 23:352-366). Here, we sought to extend this work to assess the role of the LEC in recognition of all associative combinations of objects, places and contexts within an episode. Unlike controls, rats with excitotoxic lesions of the LEC showed no evidence of recognizing familiar combinations of object in place, place in context, or object in place and context. However, LEC lesioned rats showed normal recognition of objects and places independently from each other (nonassociative recognition). Together with our previous findings, these data suggest that the LEC is critical for associative recognition memory and may bind together information relating to objects, places, and contexts needed for episodic memory formation.

show abstract

A comparison of the effects of temporary hippocampal lesions on single and dual context versions of the olfactory sequence memory task.

Cited by 7 publications

References 36 publications

Neonatal hippocampal lesions facilitate biconditional contextual discrimination learning in monkeys.

Neonatal hippocampal lesions facilitate biconditional contextual discrimination learning in monkeys.

Lateral entorhinal cortex is critical for novel object‐context recognition

Lateral entorhinal cortex is necessary for associative but not nonassociative recognition memory

Contact Info

Product

Resources

About