A Comparison of the Effects of Alpha and Medical-Grade Honey Ointments on Cutaneous Wound Healing in Rats

Paydar, Shahram; Akrami, Majid; Dehghanian, Amirreza; Moghadam, Roshanak Alavi; Heidarpour, Mohsen; Khoob, Amir Bahari; Dalfardi, Behnam

doi:10.1155/2016/9613908

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…The characterization of wound lesions indicated by improvements in area of epithelialization, angiogenesis, breaking strength, tissue granulation, collagen deposition, and wound contraction after honey treatment had been performed previously. Some studies reported that the efficiency and efficacy of honey in wound healing was comparable to other usual wound care products such as Intrasite Gel TM [ 71 ], Alpha ® ointment [ 72 ] and hydrocolloid dressing [ 71 ] but more superior than hydrofiber silver and hydrofiber dressings [ 73 ]. The aesthetic outcome of honey treatment was also reported, as thinner scars were formed at wound site of the animals [ 71 ].…”

Section: Honeymentioning

confidence: 99%

Wound Healing Properties of Selected Natural Products

Ibrahim

Wong

Mohamed

et al. 2018

IJERPH

257

170

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Wound healing is a complex process of recovering the forms and functions of injured tissues. The process is tightly regulated by multiple growth factors and cytokines released at the wound site. Any alterations that disrupt the healing processes would worsen the tissue damage and prolong repair process. Various conditions may contribute to impaired wound healing, including infections, underlying diseases and medications. Numerous studies on the potential of natural products with anti-inflammatory, antioxidant, antibacterial and pro-collagen synthesis properties as wound healing agents have been performed. Their medicinal properties can be contributed by the content of bioactive phytochemical constituents such as alkaloids, essential oils, flavonoids, tannins, saponins, and phenolic compounds in the natural products. This review highlights the in vitro, in vivo and clinical studies on wound healing promotions by the selected natural products and the mechanisms involved.

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Section: Honeymentioning

confidence: 99%

Wound Healing Properties of Selected Natural Products

Ibrahim

Wong

Mohamed

et al. 2018

IJERPH

257

170

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show abstract

“…In this study, five treatment groups were defined for the rat wound healing model: the negative control group, without treatment; Alpha ointment, as a commercial positive control group; basal gel as another positive control group; and 7 and 14 d BSEs (BSE gels) as the two treatment groups. The Alpha ointment is a routine topical medication that is used worldwide for burn wounds [94]. Meanwhile, basal gel was included in order to determine its effect on the wound healing process, as well as to ensure that the effects of the 7 and 14 d BSE gels were not because of their basal gel.…”

Section: Discussionmentioning

confidence: 99%

Tissue Extract from Brittle Star Undergoing Arm Regeneration Promotes Wound Healing in Rat

Afshar,

Khoradmehr,

Nowzari

et al. 2023

Marine Drugs

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This study set out to evaluate the wound healing properties of brittle star extracts in vitro and in vivo. Due to the great arm regeneration potential of the brittle star, Ophiocoma cynthiae, the present study aimed to evaluate the wound healing effect of hydroalcoholic extracts of brittle star undergoing arm regeneration in wound healing models. The brittle star samples were collected from Nayband Bay, Bushehr, Iran. After wound induction in the arm of brittle stars, hydroalcoholic extracts relating to different times of arm regeneration were prepared. The GC-MS analysis, in vitro MTT cell viability and cell migration, Western blot, and computational analysis tests were performed. Based on the in vitro findings, two BSEs were chosen for in vivo testing. Macroscopic, histopathological and biochemical evaluations were performed after treatments. The results showed positive proliferative effects of BSEs. Specifically, forty-two compounds were detected in all groups of BSEs using GC-MS analysis, and their biological activities were assessed. The MTT assay showed that the 14 d BSE had a higher proliferative effect on HFF cells than 7 d BSE. The cell migration assay showed that the wound area in 7 d and 14 d BSEs was significantly lower than in the control group. Western blot analysis demonstrated an increase in the expression of proliferation-related proteins. Upon the computational analysis, a strong affinity of some compounds with proteins was observed. The in vivo analysis showed that the evaluation of wound changes and the percentage of wound healing in cell migration assay in the 7 d BSE group was better than in the other groups. Histopathological scores of the 7 d BSE and 14 d BSE groups were significantly higher than in the other groups. In conclusion, the hydroalcoholic extract of O. cynthiae undergoing arm regeneration after 7 and 14 days promoted the wound healing process in the cell and rat skin wound healing model due to their proliferative and migratory biological activity.

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“…Since treatment is difficult after the formation of burn strictures, the research on treatment must be aimed at preventing stricture formation following the burn. Stricture development occurs with the development of excessive collagen during the healing process and negative wound healing [4].…”

Section: Introductionmentioning

confidence: 99%

The comparison of prednisolone and honey activities in the experimental corrosive esophagitis model

Gemici¹,

Sürek²,

Çikot³

et al. 2020

Journal of Surgery and Medicine

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This is an open access article distributed under the terms of the CreativeCommons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND 4.0) where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. AbstractAim: Honey is well known for its beneficial wound healing-related effects, including anti-edematous effects, stimulation of granulation tissue formation, chemical debridement, and immune system enhancement. In this experimental study, the effects of honey and prednisolone on stricture formation in sodium hydroxide-induced corrosive esophagitis were investigated. Methods: This study was carried out on Wistar albino rats weighing between 200-250 grams. Rats were divided into four equal groups. Corrosive esophagitis induced by 37.5% sodium hydroxide was formed in three groups. The first group received no specific treatment.The second group was treated with honey via the oral route, and the third group was treated by prednisolone intraperitoneally. The control group underwent a sham laparotomy. All subjects were sacrificed by the end of the 28 th day. A 20-mm long segment of the distal esophagus was harvested for histopathological examination. The tissue damage scores and stenosis index scores of the groups were measured and compared.Results: A total of 32 rats were included in the study, with eight subjects in each group. The mean values of stenosis index score and tissue damage score were significantly lower in the honey-treated group (P=0.001).Conclusion: Oral honey treatment seems to reduce the severity of esophageal strictures associated with corrosive esophagitis, when compared to untreated and prednisolone-treated groups. Öz Amaç: Bal antiödem etkisi, granülasyonu hızlandırıcı etkisi, enzimatik debridman ve immün sistemi güçlendirici etkisi bilinen bir doğal gıdadır. Bu deneysel çalışmanın amacı bir alkali ajan olan sodyum hidroksit ile oluşturulan koroziv özofajitte darlık gelişimi üzerine balın ve prednisolonun etkilerini araştırıldı. Yöntemler: Bu çalışma, ağırlıkları 200-250 gram arasında değişen Wistar tipi albino sıçanlar üzerinde gerçekleştirildi. Denekler, eşit sayıda dört gruba bölündü. Birinci, ikinci ve üçüncü gruplar özofajit modeli grupları olup, bu gruplardaki tüm deneklerde %37,5'luk sodyum hidroksit ile koroziv özofajit oluşturuldu. Birinci gruba herhangi bir tedavi uygulanmazken, ikici gruba oral bal tedavisi ve üçüncü gruba intraperitoneal prednisolon tedavisi uygulandı. Kontrol grubunun özofagusuna herhangi bir işlem yapılmadan şam laparotomi uygulandı. Tüm denekler 28. gün sakrifiye edildi ve deneklerin distal özofaguslarından alınan 20 mm uzunluğundaki örnekler histopatolojik incelemeye tabi tutuldu. Grupların doku hasarı skorları ve stenoz indeksi skorları ölçülerek kıyaslandı. Bulgular: Çalışmaya toplam 32 denek dahil edildi ve her bir grupta sekiz denek mevcuttu. Stenoz indeksi skoru ortalama değeri ve doku hasarı skoru ortalama değeri balla ted...

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A Comparison of the Effects of Alpha and Medical-Grade Honey Ointments on Cutaneous Wound Healing in Rats

Cited by 4 publications

References 19 publications

Wound Healing Properties of Selected Natural Products

Wound Healing Properties of Selected Natural Products

Tissue Extract from Brittle Star Undergoing Arm Regeneration Promotes Wound Healing in Rat

The comparison of prednisolone and honey activities in the experimental corrosive esophagitis model

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