A Comparison of the Effects of Quercetin Hydrate With Those of Vitamin E on the Levels of IL-13, PDGF, TNF-α, and INF-γ in Bleomycin-Induced Pulmonary Fibrosis in Rats

Malayeri, Alireza; Hemmati, Ali Asghar; Arzi, Ardeshir; Rezaie, Annahita; Ghafurian-Boroojerdnia, Mehri; Khalili, Hamidreza

doi:10.17795/jjnpp-27705

Cited by 15 publications

(9 citation statements)

References 40 publications

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“…Quercetin could also alleviate acute lung injury by decreasing oxidative stress and enhancing the activity of antioxidant enzymes [39]. When the inhibitory effects of quercetin were compared with those of vitamin E in the context of bleomycin-induced pulmonary fibrosis in rats, the antifibrotic activity of quercetin was higher than that of vitamin E [40], a well-known antioxidant. Additionally, Bidian et al evaluated the antioxidant effects of quercetin and curcumin on pleural inflammation induced by carrageenan and showed that in lung tissue, quercetin showed superior beneficial properties while in serum, curcumin had higher antioxidant effects compared to quercetin [41].…”

Section: Discussionmentioning

confidence: 98%

Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells

2021

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Oxidative stress caused by the production of reactive oxygen species (ROS) plays a major role in inflammatory processes. We hypothesized that modulation of ROS via quercetin may protect against oxidative stress and inflammation. Thus, this study aimed to investigate the effects of quercetin on oxidative stress and inflammation in lung epithelial A549 cells. The lipopolysaccharide (LPS)-induced elevation of intracellular ROS levels was reduced after quercetin treatment, which also almost completely abolished the mRNA and protein expression of nicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) induced by LPS stimulation. In addition, quercetin suppressed the nuclear translocation of nuclear factor kappa B (NF-κB) and reduced levels of inflammatory cytokine tumor necrosis factor (TNF)-α, interleukin (IL)-1, and IL-6, which had increased significantly after LPS exposure. Our data demonstrated that quercetin decreased ROS-induced oxidative stress and inflammation by suppressing NOX2 production.

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Section: Discussionmentioning

confidence: 98%

Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells

2021

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“…Administration of quercetin hydrate (25, 50, and 75 mg/kg, i.p. ), in BLM‐induced pulmonary fibrosis in rats, reduced inflammatory fibrotic factors (platelet‐derived growth factor subunit B (PDGF‐β), IL‐13, and TNF‐α) but increased antifibrotic factors (INF‐γ) in the BALF (Malayeri et al, 2016). Quercetin also decreased total leukocyte count, MDA, TNF‐α, and MMP‐7 levels in the serum or the BALF, but increased SOD and CAT activities in BLM‐induced pulmonary fibrosis in rats (Verma et al, 2013).…”

Section: Resultsmentioning

confidence: 99%

“…The protective effect of quercetin in amiodarone-induced pulmonary toxicity in rats also reduced pulmonary histopathological changes, inflammatory lung cell infiltration, but increased CAT and GSH activities (Oka, Okon, & Osim, 2019). (Malayeri et al, 2016). Quercetin also decreased total leukocyte count, MDA, TNF-α, and MMP-7 levels in the serum or the BALF, but increased SOD and CAT activities in BLM-induced pulmonary fibrosis in rats (Verma et al, 2013).…”

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confidence: 90%

Experimental and clinical studies on the effects of Portulaca oleracea L. and its constituents on respiratory, allergic, and immunologic disorders, a review

Khazdair

Saadat

Aslani

et al. 2021

Phytotherapy Research

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Various pharmacological effects for Portulaca oleracea were shown in previous studies. Therefore, the effects of P. oleracea and its derivatives on respiratory, allergic, and immunologic diseases according to update experimental and clinical studies are provided in this review article. PubMed/Medline, Scopus, and Google Scholar were searched using appropriate keywords until the end of December 2020. The effects of P. oleracea and its constituents such as quercetin and kaempferol on an animal model of asthma were shown. Portulaca oleracea and its constituents also showed therapeutic effects on chronic obstructive pulmonary disease and chronic bronchitis in both experimental and clinical studies. The possible bronchodilatory effect of P. oleracea and its ingredients was also reported. Portulaca oleracea and its constituents showed the preventive effect on lung cancer and a clinical study showed the effect of P. oleracea on patients with lung adenocarcinoma. In addition, a various constituents of P. oleracea including, quercetin and kaempferol showed therapeutic effects on lung infections. This review indicates the therapeutic effect of P. oleracea and its constituents on various lung and allergic disorders but more clinical studies are required to establish the clinical efficacy of this plant and its constituents on lung and allergic disorders.

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“…The results of laboratory and clinical studies showed that dexmedetomidine reduces inflammatory responses ( 21 , 22 ), and animal studies also showed inhibition of pro-inflammatory cytokines ( 23 ). In addition, the results of in vitro studies on whole human blood samples reported suppression of lipopolysaccharides, which produce pro-inflammatory mediators including TNF-α, interleukin-6, and IL-8 ( 24 , 25 ). Besides vasodilatory effects, alpha-2 agonists have sympathetic suppressive, sedative, and hypnotic effects ( 26 ).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Effect of Propofol and Dexmedetomidine on Hemodynamic Parameters and Stress Response Hormones During Laparoscopic Cholecystectomy Surgery

et al. 2021

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Background: General anesthesia induces endocrine, immunologic, and metabolic responses. Anesthetic drugs affect the endocrine system by changing the level of stress hormones and hemodynamic variables of the patient. Objectives: The purpose of this study was to compare the effects of propofol and dexmedetomidine on hemodynamic parameters and stress-induced hormones in laparoscopic cholecystectomy (LC) surgery. Methods: Seventy patients of elective LC were included in this study. The patients were randomly assigned into two equal groups of propofol (75 µg/kg/min) and dexmedetomidine (0.5 µg/kg/hour) as anesthesia maintenance. Hemodynamic parameters (heart rate and mean atrial pressure), blood sugar, and serum epinephrine level were monitored and recorded from pre-anesthesia period to 10 min after entry to post-anesthesia care unit (PACU) according to a planned method. Results: Heart rate and mean atrial pressure changes were significantly lower in dexmedetomidine group in all stages compared to propofol group (P < 0.001). Also, the rises in blood glucose and serum epinephrine levels in the dexmedetomidine group were significantly higher than in the propofol group (P < 0.001). Conclusions: Anesthesia maintenance by dexmedetomidine showed a significant difference in hemodynamic parameters in comparison with propofol. While dexmedetomidine had better effects on controlling hemodynamic parameters, propofol showed better effects on decreasing stress hormones, and it can be suggested for LC surgery.

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A Comparison of the Effects of Quercetin Hydrate With Those of Vitamin E on the Levels of IL-13, PDGF, TNF-α, and INF-γ in Bleomycin-Induced Pulmonary Fibrosis in Rats

Abstract: Background: Pulmonary fibrosis is a deadly and destructive disease. Various chemicals, drugs, and environmental factors are responsible for pulmonary fibrosis. The disease can also be idiopathic. A number of inflammatory mediators and cytokines, such

Cited by 15 publications

References 40 publications

Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells

Quercetin Prevents LPS-Induced Oxidative Stress and Inflammation by Modulating NOX2/ROS/NF-kB in Lung Epithelial Cells

Experimental and clinical studies on the effects of Portulaca oleracea L. and its constituents on respiratory, allergic, and immunologic disorders, a review

Comparison of the Effect of Propofol and Dexmedetomidine on Hemodynamic Parameters and Stress Response Hormones During Laparoscopic Cholecystectomy Surgery

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