A comparison of the effects of non-steroidal compounds on the disruption of the blood-aquous barrier

Haeringen, N.J. van; Oosterhuis, J. A.; Delft, J. L. Van; Glasius, E.; Noach, E. L.

doi:10.1016/s0014-4835(82)80051-1

Cited by 26 publications

(6 citation statements)

References 8 publications

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“…The pharmacological effect of diclofenac sodium as an ocular anti-inflammatory has been previously well established only in simple models such as paracentesis in which aqueous protein concentration is monitored (14)(15)(16)(17)(18), but with which the present data are in agreement. The effects of diclofenac sodium on IOP presented in Table 1 also agree with previous experiments showing that it and other nonsteroidal anti-inflammatory drugs inhibit the ocular hypertensive effect of trauma and/or arachidonic acid (19)(20)(21).…”

Section: Discussionsupporting

confidence: 63%

Effects of Topical Diclofenac Sodium in a Rabbit Model of Ocular Inflammation and Leukotaxis

Rowland¹,

Ford²,

Puca³

et al. 1986

Journal of Ocular Pharmacology and Therapeutics

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A useful model that combines paracentesis with administration of a leukotactic factor was developed in order to study the effects of topical diclofenac sodium on various aspects of ocular inflammation. The increases in intraocular pressure (IOP) and secondary aqueous humor protein concentration induced in rabbits by anterior chamber paracentesis, as well as leukocyte accumulation in the anterior chamber induced by formyl-methionyl-leucyl-phenylalanine, were significantly reduced by topical application of diclofenac sodium at concentrations of 2 mM (0.064%, w/v) and higher. Lower doses consistently affected only IOP and secondary protein concentrations.A slight paracentesisinduced miosis was refractory to diclofenac sodium. That this potent inhibitor of prostaglandin synthesis can reduce important signs of ocular inflammation is well supported in this model.

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Section: Discussionsupporting

confidence: 63%

Effects of Topical Diclofenac Sodium in a Rabbit Model of Ocular Inflammation and Leukotaxis

Rowland¹,

Ford²,

Puca³

et al. 1986

Journal of Ocular Pharmacology and Therapeutics

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“…The barrier to penetration in the cornea might be located in the superfi cial layer of the epithelium and is highly dependent on the lipid solubility of the agents [13]. This explains the relationship between the lipid solubility and drug effect we found in three non-steroidal compounds [11]. Solubility in water is also of impor tance in order to obtain a satisfactory con centration, available for penetration into the eye.…”

Section: Discussionmentioning

confidence: 99%

“…None of the authors offers an explanation as to why they selected the concentrations they used. We therefore investigated in a previous study [11], the effect of three inhibitors of prostaglandin synthesis, diclofenac, flurbiprofen and indomethacin, applied topically as a watery isotonic buffered solution, on the break down of the blood-aqueous barrier in rabbit eyes after paracentesis. A prostaglandininduced increase in the protein and fluores cein content in the secondary aqueous appeared to be inhibited in a dose-depen dent manner.…”

Section: Introductionmentioning

confidence: 99%

Drug Prevention of Blood-Aqueous Barrier Disruption

Glasius

et al. 1983

Ophthalmic Res

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In order to evaluate the anti-inflammatory effect of non-steroidal compounds on the eye, we tested them in rabbits using the inhibitory effect on paracentesis-induced disruption of the blood-aqueous barrier. Protein and – after intravenous-injection – fluorescein were determined in punctates of aqueous humor. Indomethacin, fluorbiprofen and diclofenac in a 0.01% solution showed a marked inhibitory effect, which lasted for 24 h. Addition of polysorbate to eye drugs diminished the inhibitory effect.

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“…Indometacin und Flurbiprofen als vom Bun desgesundheitsamt (BGA) für unterschied liche Indikationsbereiche zugelassene, lokal applizierbare, nichtsteroidale Antiphlogistika hemmen die Zyklooxygenase, die die Arachi donsäure in die Prostaglandine umsetzt [1]. Die Lokaltherapie mit diesen Antiphlogistika führt im Tierversuch zur Hemmung der Pro staglandinsynthese [2,3], verhindert im Expe riment den Zusammenbruch der Blutkammer wasserschranke [4,5] …”

unclassified

kammervasserkonzentrationen nichtsteroidaler Antiphlogistika

Strobel¹

1991

Ophthalmologica

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In a prospective randomised study we tested two non-steroidal anti-inflammatory medications clinically in a group of 40 eyes. 20 eyes received topically administered indometacin and another 20 flurbiprofen eyedrops. Before we started the planned extracapsular cataract extraction we performed a puncture of the anterior chamber and aspirated a small volume of anterior chamber fluid. We examined the concentrations of the applied drugs in the aspirated volume. The concentration of indometacin is 7–9 times higher than that of flurbiprofen.

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A comparison of the effects of non-steroidal compounds on the disruption of the blood-aquous barrier

Cited by 26 publications

References 8 publications

Effects of Topical Diclofenac Sodium in a Rabbit Model of Ocular Inflammation and Leukotaxis

Effects of Topical Diclofenac Sodium in a Rabbit Model of Ocular Inflammation and Leukotaxis

Drug Prevention of Blood-Aqueous Barrier Disruption

kammervasserkonzentrationen nichtsteroidaler Antiphlogistika

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