Drug Prevention of Blood-Aqueous Barrier Disruption

Abstract

In order to evaluate the anti-inflammatory effect of non-steroidal compounds on the eye, we tested them in rabbits using the inhibitory effect on paracentesis-induced disruption of the blood-aqueous barrier. Protein and – after intravenous-injection – fluorescein were determined in punctates of aqueous humor. Indomethacin, fluorbiprofen and diclofenac in a 0.01% solution showed a marked inhibitory effect, which lasted for 24 h. Addition of polysorbate to eye drugs diminished the inhibitory effect.

Effects of Topical Diclofenac Sodium in a Rabbit Model of Ocular Inflammation and Leukotaxis

“…The pharmacological effect of diclofenac sodium as an ocular anti-inflammatory has been previously well established only in simple models such as paracentesis in which aqueous protein concentration is monitored (14)(15)(16)(17)(18), but with which the present data are in agreement. The effects of diclofenac sodium on IOP presented in Table 1 also agree with previous experiments showing that it and other nonsteroidal anti-inflammatory drugs inhibit the ocular hypertensive effect of trauma and/or arachidonic acid (19)(20)(21).…”

Corneal metabolism and epithelial barrier function after cataract surgery and intraocular lens implantation: a fluorophotometric study

“…Indomethacin gives in general protection against breakdown of ocular barriers after surgery [21,22]. No increasing effect on the corneal epithelial permeability could be found in the short term test in healthy volunteers.…”

Blood-Aqueous Barrier Disruptionin Expe rimental Anterior Segment Ischemia in Rabbit Eyes

“…The effect of aspirin, indomethacin, and flurbiprofen on BAB dysfunction is well established [26][27][28]. These drugs act as inhibitors of prostaglandin synthesis and maintain the normal function of the BAB [29].…”