Blood-Aqueous Barrier Disruptionin Expe rimental Anterior Segment Ischemia in Rabbit Eyes

Abstract

The blood-aqueous barrier (BAB) in experimentally induced anterior segment ischemia (ASI) following strabismus or retinal detachment surgery in pigmented rabbits was evaluated by laser flare photometry. Four simultaneous rectus tenotomies produced a significantly higher flare value on the 1st postoperative day. Obstruction of one or two vortex veins produced significantly high flare values on the 1st and 3rd postoperative days. Scleral buckling with interference of one vortex vein produced a higher flare value than that with buckling alone. Interference of three vortex veins by diathermy and the encircling procedure produced serious ASI. Disruption of BAB in ASI can be detected quantitatively with laser flare photometry. Introduction of prostaglandin synthetase inhibitor resulted in a significant reduction of flare values following surgery. Prostaglandin synthetase inhibitor can partly ameliorate BAB disruption.

Plasma and aqueous humour levels of homocysteine in exfoliation syndrome

“…The blood-aqueous barrier (BAB) restricts protein access from the circulation into the aqueous humour, but in experimentally induced anterior segment ischaemia, disruption of BAB could be detected with laser flare photometry [14]. There are divergent opinions on the likelihood that XFS enhances the aqueous protein concentration.…”

Blood–aqueous barrier integrity in patients with Graves’ ophthalmopathy (GO), before and after rehabilitative surgery

“…Extraocular muscle surgery carries the risk of anterior segment ischemia, which increases with the number of muscles being operated on in the same eye. Anterior chamber ischemia would be expected to cause blood-aqueous barrier breakdown 23 . Although BAB has been demonstrated to remain unchanged during squint surgery in children 24 , it is not known, what are the effects of surgery to relieve extraocular muscle restriction in GO.…”