A comparison of the efficacy and safety of traditional Chinese medicine external treatment for the knee osteoarthritis

Song, Xu-Yu; Wang, Zhao; Zhang, Peng; Zhao, Min; Yang, Lingsen; Wei, Zhang

doi:10.1097/md.0000000000024115

Cited by 6 publications

(5 citation statements)

References 14 publications

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“…Its effect mainly relieves OA symptoms and delays cartilage wear ( Yao et al, 2021 ); it also has the advantages of a stable curative effect, low cost, and small side effects. In addition to internal and external administration of Chinese medicine, effective treatments of OA have been reported for needle therapy ( Mao and Kapur, 2010 ; Fu et al, 2020 ), moxibustion ( Wang et al, 2020 ), Tai chi ( Chen et al, 2021 ; Zheng et al, 2021 ), baduanjin ( Li J et al, 2020 ), and other non-drug treatments ( Song et al, 2021 ). However, insignificant effects over the corresponding placebo have been reported in reducing pain or improving function in patients with KOA ( Lao et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Zhuifeng tougu capsules inhibit the TLR4/MyD88/NF-κB signaling pathway and alleviate knee osteoarthritis: In vitro and in vivo experiments

et al. 2022

Front. Pharmacol.

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Background: Knee osteoarthritis (KOA), a chronic degenerative disease, is mainly characterized by destruction of articular cartilage and inflammatory reactions. At present, there is a lack of economical and effective clinical treatment. Zhuifeng Tougu (ZFTG) capsules have been clinically approved for treatment of OA as they relieve joint pain and inflammatory manifestations. However, the mechanism of ZFTG in KOA remains unknown.Purpose: This study aimed to investigate the effect of ZFTG on the TLR4/ MyD88/NF-κB signaling pathway and its therapeutic effect on rabbits with KOA. Study design:In vivo, we established a rabbit KOA model using the modified Videman method. In vitro, we treated chondrocytes with IL-1β to induce a proinflammatory phenotype and then intervened with different concentrations of ZFTG. Levels of IL-1β, IL-6, TNF-α, and IFN-γ were assessed with histological observations and ELISA data. The effect of ZFTG on the viability of chondrocytes was detected using a Cell Counting Kit-8 and flow cytometry. The protein and mRNA expressions of TLR2, TLR4, MyD88, and NF-κB were detected using Western blot and RT-qPCR and immunofluorescence observation of NF-κB p65 protein expression, respectively, to investigate the mechanism of ZFTG in inhibiting inflammatory injury of rabbit articular chondrocytes and alleviating cartilage degeneration.Results: The TLR4/MyD88/NF-κB signaling pathway in rabbits with KOA was inhibited, and the levels of IL-1β, IL-6, TNF-α, and IFN-γ in blood and cell were significantly downregulated, consistent with histological results. Both the protein and mRNA expressions of TLR2, TLR4, MyD88, NF-κB, and NF-κB p65 proteins in that nucleus decreased in the ZFTG groups. Moreover, ZFTG

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Section: Discussionmentioning

confidence: 99%

Zhuifeng tougu capsules inhibit the TLR4/MyD88/NF-κB signaling pathway and alleviate knee osteoarthritis: In vitro and in vivo experiments

et al. 2022

Front. Pharmacol.

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“…The physique of the elderly is mostly in the state of liver and kidney deficiency and old age strain, with the loss of qi, blood, and yin and yang. They are vulnerable to exogenous pathogens such as wind, cold, and dampness, which can cause arthralgia of joints and meridians, affect the movement of qi and blood, and eventually lead to cold coagulation and stasis, arthralgia, and cold-dampness KOA [ 6 , 7 ]. Moxibustion is a traditional Chinese medicine treatment method.…”

Section: Introductionmentioning

confidence: 99%

Effect of Moxibustion Instrument Combined with Intermediate Frequency Electrostatic Therapy on Pain and Joint Function in Elderly Patients with Cold-Dampness Knee Arthritis

Cui

Bai

2022

Computational and Mathematical Methods in Medicine

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Objective. To explore the effect of a moxibustion instrument combined with intermediate frequency electrostatic therapy on pain and joint function in elderly patients with cold-dampness arthritis (KOA). Method. 200 patients with cold-dampness KOA treated in our hospital from May 2019 to September 2021 were selected. According to the random number table method, they were divided into the observation group ( n = 100 ) and control group ( n = 100 ). The observation group was treated with moxibustion combined with medium-frequency treatment, and the control group was treated with medium-frequency treatment. The clinical effects of the two groups were compared. The joint functions of the two groups were evaluated by the visualization scale of the osteoarthritis index (WOMAC index) of McMaster University in Western Ontario. The TCM symptom scores of the two groups were evaluated according to the guiding principles for clinical research of new traditional Chinese medicine. The visual analogue scale (VAS) was used to evaluate the pain degree of the two groups, and the microcirculatory blood perfusion (MBPU) and interleukin-1 were compared between the two groups, β (IL-1β) and tumor necrosis factor-α (TNF-α). The levels of matrix metalloproteinase-1 (MMP-1), serum bone morphogenetic protein-2 (BMP-2), cartilage oligomeric matrix protein (COMP), and serum type II collagen C-terminal peptide (CTX-II) were assessed by the comprehensive quality of life questionnaire-74. Result. The total effective rate of the observation group (92.00%) was higher than that of the control group (76.00%), and the difference was statistically significant ( P < 0.05 ) in β and TNF-α. The levels of MMP-3, BMP-2, comp, and CTX-II and the improvement of quality of life score in the control group were better than those in the control group ( P < 0.05 ). Conclusion. Moxibustion instrument combined with intermediate frequency electrostatic therapy can effectively improve the knee joint function, pain, blood perfusion, inflammatory reaction, and cartilage damage of the elderly patients with cold-dampness-type knee arthritis, and the therapeutic effect is good.

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“…As a chronic progressive joint disease, osteoarthritis inflicts harm to the physical and mental health of the middle-aged and the elderly patients [ 1 ]. Pathologically, OA is characterized by simultaneous catabolic and anabolic processes which cause changes in all joint tissues.…”

Section: Introductionmentioning

confidence: 99%

Exploratory Compatibility Regularity of Traditional Chinese Medicine on Osteoarthritis Treatment: A Data Mining and Random Walk-Based Identification

Zhou

Liu

Xin

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Osteoarthritis (OA) is a degressive and complex disease which is a growing public health problem on a global scale. On basis of an in-house database consisting of clinical records of 13,083 OA patients, the Traditional Chinese Medicine (TCM) was divided into 4 categories of medicines on the basis of the curative properties of herbs. Due to the lack of depth and internal relationship in the calculation results of TCM compatibility law data mining methods such as statistics and frequency analysis, we use a variety of multidimensional complex network methods that can efficaciously find the compatibility law of TCM, including similarity measure, graphical visualization of network diagram, random walking, and propensity score methods. We summarize common couplet medicines utilized for the treatment of osteoarthritis. The similarity measure method was used to investigate the commonly used drugs for the treatment of osteoarthritis. The method of association rule analysis is used to recognize the compatibility between the components. On basis of the propensity score methods, the evaluation displayed that, compared with single drug, the drug group increased ESR, CRP, C3, C4, IgG, and IgA more efficiently. Concluding, a random walk model was constructed to assess drug efficacy. After applying a random walk model, while revealing the compatibility among different components of TCM, their therapeutic efficacy against OA is analyzed. We obtained four groups of drug combination clusters by similarity measure and 11 pairs of highly connected drugs by association rules, which are cardinal drug combinations in the prescription for the treatment of OA. We also found that different traditional drug pairs were associated with different laboratory indexes, and drug combinations could better optimize laboratory indexes. This study presented that the TCM constituents complement one another. Besides, the therapeutic effects resulting from a variety of combinations of these constituents are quite different.

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A comparison of the efficacy and safety of traditional Chinese medicine external treatment for the knee osteoarthritis

Cited by 6 publications

References 14 publications

Zhuifeng tougu capsules inhibit the TLR4/MyD88/NF-κB signaling pathway and alleviate knee osteoarthritis: In vitro and in vivo experiments

Zhuifeng tougu capsules inhibit the TLR4/MyD88/NF-κB signaling pathway and alleviate knee osteoarthritis: In vitro and in vivo experiments

Effect of Moxibustion Instrument Combined with Intermediate Frequency Electrostatic Therapy on Pain and Joint Function in Elderly Patients with Cold-Dampness Knee Arthritis

Exploratory Compatibility Regularity of Traditional Chinese Medicine on Osteoarthritis Treatment: A Data Mining and Random Walk-Based Identification

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