A Comparison of the Efficacy of Ketorolac and Indomethacin for Postoperative Analgesia following Laparoscopic Surgery in Day Patients

Murrell, Graeme; Leake, T.; Hughes, Peter J.

doi:10.1177/0310057x9602400216

Cited by 10 publications

(2 citation statements)

References 23 publications

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“…24 The results of clinical trials regarding the value of NSAIDs in achieving preemptive analgesia are controversial. 25 Broad preemptive effects were reported by some authors [26][27][28][29] but denied by others. 30,31 The limitation of NSAIDs as preemptive analgesic agents arises from the difficulty in establishing objective, effective analgesic levels prior to surgical trauma.…”

Section: Postoperative Painmentioning

confidence: 97%

Pain Associated with Carotid Artery Surgery Performed under Carotid Plexus Block: Preemptive Analgesic Effect of Ketorolac

Sindjelić¹,

Davidović²,

Vlajković³

et al. 2006

Vascular

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Carotid artery surgery (CAS) performed under cervical plexus block is frequently associated with significant intra- and postoperative pain. To evaluate whether preoperative administration of ketorolac may improve analgesia in this type of surgery, 80 patients scheduled for CAS under cervical plexus block were randomly allocated to receive intravenously either 30 mg of ketorolac or placebo 30 minutes before surgery. Verbal rating scale pain scores during surgery and 3 and 6 hours after surgery, the number of patients requiring additional analgesia, and the total analgesic consumption both during and within 6 hours after surgery were significantly lower, whereas the time to first postoperative analgesia was significantly shorter in the ketorolac group than in the control group. The results of this prospective, randomized, double-blind study show that a single 30 mg dose of ketorolac administered intravenously 30 minutes before surgery reduces intraoperative pain and preempts postoperative pain in patients undergoing CAS under carotid plexus block.

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Section: Postoperative Painmentioning

confidence: 97%

Pain Associated with Carotid Artery Surgery Performed under Carotid Plexus Block: Preemptive Analgesic Effect of Ketorolac

Sindjelić¹,

Davidović²,

Vlajković³

et al. 2006

Vascular

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“…Ketorolac, an injectable NSAID, has been reported to be comparable with pethidine 3 and morphine 4,5 when used as a postoperative analgesic. Its use in laparoscopy by bolus dose has resulted in reduced recovery time 6 , lower pain scores 7 and a lower incidence of side-effects 8 . However, these findings have not been consistent, with some studies reporting no difference from placebo 9,10 .…”

mentioning

confidence: 99%

Effect of Short-Term Ketorolac Infusion on Recovery following Laparoscopic Day Surgery

Campbell

Plummer

Owen

et al. 2000

Anaesth Intensive Care

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This study tested the hypothesis that, by the addition of parenteral ketorolac to an oral analgesic regimen for one day following laparoscopic surgery, analgesia would be improved and thus the return of normal function hastened. Seventy-two female patients were randomly assigned to receive ketorolac 10.5 mg subcutaneously at the end of surgery followed by a subcutaneous infusion of 1.75 mg/h for 24 to 36 hours, or an equivalent volume of saline. All patients were provided with codeine tablets (30 mg) for analgesia if required. For the first four postoperative days patients recorded details of pain, side-effects and discomfort on performing everyday activities. Patients who received ketorolac received significantly less fentanyl in the Recovery Ward and significantly less codeine prior to discharge than the saline group. They also took significantly fewer codeine tablets over the four-day postoperative period. Pain scores in the ketorolac group were not significantly lower than in the saline group on the first postoperative day (P=0.052) and subsequently remained similar. Levels of discomfort on performing six common activities were similar in the two groups over the four-day postoperative period. We conclude that, despite beneficial effects during the period of ketorolac administration, there was no continuing benefit after this time other than reduced analgesic use, and no improvement in the patients' ability to perform common activities.

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Effects of nonsteroidal anti-inflammatory drugs on postoperative renal function in adults with normal renal function

Lee

Cooper

Craig

et al. 2007

Cochrane Database of Systematic Reviews

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A Comparison of the Efficacy of Ketorolac and Indomethacin for Postoperative Analgesia following Laparoscopic Surgery in Day Patients

Cited by 10 publications

References 23 publications

Pain Associated with Carotid Artery Surgery Performed under Carotid Plexus Block: Preemptive Analgesic Effect of Ketorolac

Pain Associated with Carotid Artery Surgery Performed under Carotid Plexus Block: Preemptive Analgesic Effect of Ketorolac

Effect of Short-Term Ketorolac Infusion on Recovery following Laparoscopic Day Surgery

Effects of nonsteroidal anti-inflammatory drugs on postoperative renal function in adults with normal renal function

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