A Comparison of the Efficacy, Safety, and Patient Satisfaction of Ondansetron Versus Droperidol as Antiemetics for Elective Outpatient Surgical Procedures

The use of droperidol decreases postoperative nausea and vomiting after gynecological laparoscopy

“…In this study, the incidence of PONV was 17% after using 2.5 mg droperidol. It has been reported that the incidences of PONV were 37% after using 0.625 mg droperidol and 31% after using 1.25 mg droperidol [6]. With increasing doses, droperidol's anti-vomiting effi cacy improved considerably, although doses beyond 2.5 mg did not further increase effi cacy [7].…”

The effectiveness of rescue antiemetics after failure of prophylaxis with ondansetron or droperidol: a preliminary report

“…We analyzed data collected in a previously published large multicenter study [2] to assess the effectiveness of different antiemetics for the treatment of established PONV in patients who failed prophylaxis.…”

“…Moreover, it is unclear if an antiemetic acting on a different receptor system would constitute a better treatment option in patients who experience PONV despite receiving a prophylactic antiemetic. We reexamined the database of a previously published large multicenter study to determine the efficacy of rescue antiemetics in patients who failed prophylaxis with ondansetron 4 mg and droperidol 0.625 to 1.25 mg [2]. We hypothesized that in patients who fail prophylaxis with one antiemetic, a rescue agent working at a different receptor would have a higher success rate compared with a repeat dose of the same antiemetic used for prophylaxis.…”

Anesthesia for laparoscopy: a review

“…Although ondansetron (an antagonist of the 5-HT3 receptor), is as effective as older antiemetics such as droperidol [97] or cyclizine [98], it avoids most of their adverse effects. Ondansetron given at the end of surgery results in a significantly greater antiemetic effect, compared with preinduction dosing [99].…”