A Comparison of the Healing Capabilities of Various Grafting Materials in Critical-Size Defects in Guinea Pig Calvaria

Yazdi, Farin Kiany; Mostaghni, Ehsan; Moghadam, Somaye Ansari; Faghihi, Sharieh; Monabati, Ahmad; Amid, Reza

doi:10.11607/jomi.2906

Cited by 19 publications

(15 citation statements)

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“…Allografts, despite being used with some frequency in regenerative treatments in some areas of medicine, these materials are not one of the first-choice materials in dentistry. There is still some controversy regarding their osteoinductivity, as well as their risk of immune rejection, blood incompatibility, and disease transmission [2,12,18].…”

Section: Allograftsmentioning

confidence: 99%

“…Allogeneic materials are considered a source of type I collagen and morphogenetic proteins (BMPs), which give them osteoinductive capabilities. However, although they originate from the human species, they have different genetic compositions, which raises controversy about immunological rejection, blood compatibility, and transmission of diseases or tumour cells [2,12,18]. Considered osteoinductive and osteoconductive, they do not have osteogenic properties, and their processing ends up reducing their biological and mechanical characteristics [2,12,18].…”

Section: Allograftsmentioning

confidence: 99%

“…Although with some advantages similar to autogenous bone and greater availability, allogeneic materials have a high processing cost, in addition to the already mentioned disadvantages regarding disease transmission, immunological rejection, and religious issues [2,12,18].…”

Section: Allograftsmentioning

confidence: 99%

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Bone Grafts in Dental Medicine: An Overview of Autografts, Allografts and Synthetic Materials

Ferraz

2023

Materials

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This review provides an overview of various materials used in dentistry and oral and maxillofacial surgeries to replace or repair bone defects. The choice of material depends on factors such as tissue viability, size, shape, and defect volume. While small bone defects can regenerate naturally, extensive defects or loss or pathological fractures require surgical intervention and the use of substitute bones. Autologous bone, taken from the patient’s own body, is the gold standard for bone grafting but has drawbacks such as uncertain prognosis, surgery at the donor site, and limited availability. Other alternatives for medium and small-sized defects include allografts (from human donors), xenografts (from animals), and synthetic materials with osteoconductive properties. Allografts are carefully selected and processed human bone materials, while xenografts are derived from animals and possess similar chemical composition to human bone. Synthetic materials such as ceramics and bioactive glasses are used for small defects but may lack osteoinductivity and moldability. Calcium-phosphate-based ceramics, particularly hydroxyapatite, are extensively studied and commonly used due to their compositional similarity to natural bone. Additional components, such as growth factors, autogenous bone, and therapeutic elements, can be incorporated into synthetic or xenogeneic scaffolds to enhance their osteogenic properties. This review aims to provide a comprehensive analysis of grafting materials in dentistry, discussing their properties, advantages, and disadvantages. It also highlights the challenges of analyzing in vivo and clinical studies to select the most suitable option for specific situations.

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Section: Allograftsmentioning

confidence: 99%

Section: Allograftsmentioning

confidence: 99%

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Bone Grafts in Dental Medicine: An Overview of Autografts, Allografts and Synthetic Materials

Ferraz

2023

Materials

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“…Due to substantial limitations and disadvantages pertaining to autografts and xenografts, the use of another grafting technique known as alloplastic bone grafts and their efficacy in various fields have been studied and researched in recent years [ 14 , 15 ]. Alloplastic bone graft materials can be described as “synthetic,” indicating that they are manufactured from non-organic sources.…”

Section: Introductionmentioning

confidence: 99%

Bicalcium Phosphate as an Asset in Regenerative Therapy

Maheshwari,

Taori,

Bajaj

et al. 2023

Cureus

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After a loss of a tooth, alveolar bone resorption is immutable, leaving the area devoid of sufficient bone quality and mass for a successful and satisfactory implant or any other dental treatment. To treat this problem of irreversible bone loss, bone grafting is the primary solution and a well-accepted technique. The use of bone grafting procedures has increased in recent years. This review is about the various bone grafting techniques and best-situated material available currently along with their trump cards and limitations. In the thorough discussion regarding bone grafting materials and their substitutes, one alloplastic material has shown unbeaten and the most satisfactory properties than any other material, “bicalcium phosphate” (BCP). BCP is a mixture of hydroxyapatite (HA) and beta-tricalcium phosphate (B-TCP) usually obtained through sintering calcium-deficient apatite (CDA) at or above 700°C or by other methods such as hydrolysis or precipitation. The review also shows comparative studies done to understand the effect, most adequate balance, and impact of ratios of HA/B-TCP on the properties, structure, and success rate of this material. The objective of the review is to enlighten the principal characteristic of the most likely used bone graft material presently, i.e., BCP. The most impeccable characteristic of BCP is its capability to osteointegrate, which results in a superior interface. This interface depicts a dynamic process that includes physicochemical reactions, crystal-protein interactions, cell and tissue colonization, and bone remodeling. BCP has certain essential properties that could be put forth as its advantage over any other substitute. These properties include bioactivity, osteointegration, osteoinduction, osteogenesis, and biodegradation, which are mostly governed by modifying the HA/B-TCP ratio. Other applications of BCP are feasible, such as in drug administration and scaffolds for tissue engineering.

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“…However, the isolated use of the DBB has been showed to promote reduced bone formation (Yazdi et al, 2013) and less degree of osseointegration than areas grafted with autogenous bone (Jensen et al, 2013), and this fact can represent a delay in the implants placement and loading.…”

Section: Introductionmentioning

confidence: 99%

Osseointegration of different implant surfaces in areas grafted with deproteinized bovine bone associated or not with fresh bone marrow—Preclinical study in rabbits

Leocádio

Oliveira

et al. 2021

Clinical Oral Implants Res

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Objectives: To assess the influence of two different implant surfaces on osseointegration in maxillary sinuses of rabbits previously grafted with deproteinized bovine bone (DBB) associated or not with fresh bone marrow (BM).Material and methods: Sixteen New Zealand albino rabbits (males, 3.5/4.5 kg and 9-12 months old) were randomly divided into two groups with 8 rabbits each, according to the type of association of biomaterials used to fill the animals' maxillary sinuses: DBB (Deproteinized Bovine Bone) and DBB/BM (Deproteinized bovine bone associated with fresh autologous bone marrow). Ninety (90) days following the grafting procedure, the animals received implants in the area with two different microstructures (SA-Sandblasting + acid attack and SA-H-Sandblasting + acid attack + immersion in 0.9% sodium chloride isotonic solution). All rabbits were euthanized 90 days after implant placement. The microtomographic analysis was performed to verify the number of mineralized tissues around the implants throughout their length (%BV/ TV), while the histomorphometric analysis was performed to verify the percentage of bone-implant contact around the implants throughout their length (%BIC). Results:We observed no differences in the quantity for %BV/TV

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A Comparison of the Healing Capabilities of Various Grafting Materials in Critical-Size Defects in Guinea Pig Calvaria

Abstract: The results of this study indicated that all the testing materials had different capacities to produce new bone in CSD of guinea pig calvaria. MBCP Gel showed promising results in producing new bone proportionate to the autogenous bone graft group.

Cited by 19 publications

References 0 publications

Bone Grafts in Dental Medicine: An Overview of Autografts, Allografts and Synthetic Materials

Bone Grafts in Dental Medicine: An Overview of Autografts, Allografts and Synthetic Materials

Bicalcium Phosphate as an Asset in Regenerative Therapy

Osseointegration of different implant surfaces in areas grafted with deproteinized bovine bone associated or not with fresh bone marrow—Preclinical study in rabbits

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