A comparison of the measured and predicted flowfield in a patient-specific model of an abdominal aortic aneurysm

O'Rourke, Malachy; McCullough, James P.

doi:10.1243/09544119jeim357

Cited by 18 publications

(14 citation statements)

References 20 publications

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“…Their findings implicate that the resistance to blood flow decreases as the diameter of an aneurysm increases, and in practical purposes, turbulence is not a significant factor. Although they adopted a computational fluid dynamics method in their analysis, it is reported to agree well with the realistic measurements [19]. From the fluid dynamics point of view, an aneurysm is like the development of collateral circulations in terms of cause and effect; actually, they commonly occur together [5,8].…”

Section: Discussionmentioning

confidence: 72%

“…This study showed that CA stenosis and PDA aneurysm can provoke each other in reverse directions. CA stenosis provokes PDA aneurysm by increasing PDA flow if it is already compromised with wall tension-weakening conditions such as segmental arterial mediolysis, Marfan syndrome, or atherosclerosis [3,19]. Conversely, PDA aneurysm and/or arterial collaterals can provoke CA stenosis by decreasing CA flow if it is already compromised by wall tension-increasing conditions such as median arcuate ligament syndrome or atherosclerosis [6].…”

Section: Discussionmentioning

confidence: 99%

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Causal Relationship between Celiac Stenosis and Pancreaticoduodenal Artery Aneurysm: Interpretation by Simulation Using an Electric Circuit

Yoon

Choi

Shin

et al. 2020

BioMed Research International

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Pancreaticoduodenal artery (PDA) aneurysm and celiac artery (CA) stenosis are rare diseases in themselves. Interestingly, however, there are more cases documented in the literature in which these two disease entities occurred together than could be coincidental, and CA stenosis has been suggested as the provocative condition in developing PDA aneurysm. This study is aimed at examining the causal relationship between CA stenosis and PDA aneurysm by simulating the splanchnic circulation with an electric circuit. A patient with multiple PDA aneurysms and collaterals with CA stenosis was treated in our institution using hybrid techniques. The patient’s pre- and postoperative status was simulated using an electric circuit, and the two possible scenarios were tested for compatibility: the stenosis-first scenario vs. the aneurysm-first scenario. The simulation was performed in two ways: using Simulink® software (MATLAB® Release 2018b) and actual circuit construction on a breadboard. The stenosis-first scenario showed that as the CA stenosis progresses, the blood flow through PDA increases, favoring the development of an aneurysm and/or collaterals if the artery was already compromised by a weakening condition. On the other hand, the aneurysm-first scenario also showed that if the aneurysm or collaterals developed first, the aneurysm will steal the blood flow through the CA, causing it to collapse if the artery was already compromised by increased wall tension. Contrary to the common belief, this study showed that in patients suffering from concurrent CA stenosis and PDA aneurysm, either condition could develop first and predispose the development of the other. The simulation of splanchnic blood flow with an electric circuit provides a useful tool for analyzing rare vascular diseases that are difficult to provoke in clinical and animal studies.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Causal Relationship between Celiac Stenosis and Pancreaticoduodenal Artery Aneurysm: Interpretation by Simulation Using an Electric Circuit

Yoon

Choi

Shin

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…14 The methodology used to obtain the images has been reported in detail previously. 12 However, in the interest of completeness, the technique is briefly summarised as follows. Neutrally buoyant 50 mm particles were (7) introduced to the flow and illuminated by a laser light sheet generated from a 100 mW argon ion laser.…”

Section: Velocity Fieldmentioning

confidence: 99%

An investigation of the relationship between hemodynamics and thrombus deposition within patient-specific models of abdominal aortic aneurysm

O'Rourke

McCullough

Kelly

2012

Proc Inst Mech Eng H

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The relationship between hemodynamics and thrombus deposition in abdominal aortic aneurysm is investigated for three patients (A, B and C), each with mature fusiform aneurysms. Our methodology utilises initial and follow-up computerised tomography scans for each patient to identify regions of mural thrombus growth and to provide patient-specific models for hemodynamic analysis using computational fluid dynamics. The intervals between scans for patients A, B and C were 17, 15 and 3 months, respectively. The simulations were performed using physiologically realistic boundary conditions. The hemodynamic features of the flow considered include the velocity field, the shear strain rate field, the time averaged wall shear stress and the oscillatory shear index. The parameter that showed best correlation with the location of thrombus growth was the oscillatory shear index. In particular, in the case of patient C where the interval between scans was the shortest, thrombus growth was observed at regions of low oscillatory shear index (OSI < 0.1).

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“…The patient-based geometries described in this article were selected and generated by Dr James McCullough during work carried out in Dartmouth College, Hanover, NH. 20,21 Secured release was obtained from the patients involved. For each geometry, computerised tomography (CT) was used to produce a series of overlapping slices of 2.5 mm thickness.…”

Section: Geometry Creationmentioning

confidence: 99%

Fluid, solid and fluid–structure interaction simulations on patient-based abdominal aortic aneurysm models

Kelly

O'Rourke

2012

Proc Inst Mech Eng H

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This article describes the use of fluid, solid and fluid-structure interaction simulations on three patient-based abdominal aortic aneurysm geometries. All simulations were carried out using OpenFOAM, which uses the finite volume method to solve both fluid and solid equations. Initially a fluid-only simulation was carried out on a single patient-based geometry and results from this simulation were compared with experimental results. There was good qualitative and quantitative agreement between the experimental and numerical results, suggesting that OpenFOAM is capable of predicting the main features of unsteady flow through a complex patient-based abdominal aortic aneurysm geometry. The intraluminal thrombus and arterial wall were then included, and solid stress and fluid-structure interaction simulations were performed on this, and two other patient-based abdominal aortic aneurysm geometries. It was found that the solid stress simulations resulted in an under-estimation of the maximum stress by up to 5.9% when compared with the fluid-structure interaction simulations. In the fluid-structure interaction simulations, flow induced pressure within the aneurysm was found to be up to 4.8% higher than the value of peak systolic pressure imposed in the solid stress simulations, which is likely to be the cause of the variation in the stress results. In comparing the results from the initial fluid-only simulation with results from the fluid-structure interaction simulation on the same patient, it was found that wall shear stress values varied by up to 35% between the two simulation methods. It was concluded that solid stress simulations are adequate to predict the maximum stress in an aneurysm wall, while fluid-structure interaction simulations should be performed if accurate prediction of the fluid wall shear stress is necessary. Therefore, the decision to perform fluid-structure interaction simulations should be based on the particular variables of interest in a given study.

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A comparison of the measured and predicted flowfield in a patient-specific model of an abdominal aortic aneurysm

Cited by 18 publications

References 20 publications

Causal Relationship between Celiac Stenosis and Pancreaticoduodenal Artery Aneurysm: Interpretation by Simulation Using an Electric Circuit

Causal Relationship between Celiac Stenosis and Pancreaticoduodenal Artery Aneurysm: Interpretation by Simulation Using an Electric Circuit

An investigation of the relationship between hemodynamics and thrombus deposition within patient-specific models of abdominal aortic aneurysm

Fluid, solid and fluid–structure interaction simulations on patient-based abdominal aortic aneurysm models

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