A Comparison of the Mortality Rate After Elective Repair of Aortic Aneurysms Detected Either by Screening or Incidentally

Cd, Irvine; Shaw, E.; Poskitt, K. R.; Mr, Whyman; Earnshaw, J. J.; Bp, Heather

doi:10.1053/ejvs.2000.1187

Cited by 22 publications

(16 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…115 Mean 30-day mortality rate has been reported at between 1•1% and 7•0%. [116][117][118][119][120][121] Between 1998 and 2003, 453 patients were admitted to the University Hospital of Liège, Belgium, for elective repair of an abdominal aortic aneurysm (397 by open surgery and 56 by endovascular repair); the overall 30-day mortality, regardless of the risk factors, after open surgery and endovascular repair was 2•7% and 1•8%, respectively. Most deaths resulting from the repair occurred in the so-called high-risk patients.…”

Section: Risk Of Elective Aneurysm Repairmentioning

confidence: 99%

Abdominal aortic aneurysm

2005

View full text Add to dashboard Cite

Abdominal aortic aneurysms cause 1.3% of all deaths among men aged 65-85 years in developed countries. These aneurysms are typically asymptomatic until the catastrophic event of rupture. Repair of large or symptomatic aneurysms by open surgery or endovascular repair is recommended, whereas repair of small abdominal aortic aneurysms does not provide a significant benefit. Abdominal aortic aneurysm is linked to the degradation of the elastic media of the atheromatous aorta. An inflammatory cell infiltrate, neovascularisation, and production and activation of various proteases and cytokines contribute to the development of this disorder, although the underlying mechanisms are unknown. In this Seminar, we aim to provide an updated review of the pathophysiology, current and new diagnostic procedures, assessment, and treatment of abdominal aortic aneurysm to provide family practitioners with a working knowledge of this disorder.

show abstract

Section: Risk Of Elective Aneurysm Repairmentioning

confidence: 99%

Abdominal aortic aneurysm

2005

View full text Add to dashboard Cite

show abstract

“…Upon the insufficient-effective medical treatment to date, AAA rupture remains a significant cause of mortality in the elderly. The status is further complicated by the fact that surgical intervention in and of itself is associated with a 10% risk of death [ 1 ]. Under the increase in the aged prevalence in AAA, novel medical treatments intend reducing the progression of AAA have been expected.…”

Section: Introductionmentioning

confidence: 99%

Dipeptidyl Peptidase-4 Inhibitor Decreases Abdominal Aortic Aneurysm Formation through GLP-1-Dependent Monocytic Activity in Mice

Huang

Shih

et al. 2015

PLoS ONE

View full text Add to dashboard Cite

Abdominal aortic aneurysm (AAA) is a life-threatening situation affecting almost 10% of elders. There has been no effective medication for AAA other than surgical intervention. Dipeptidyl peptidase-4 (DPP-4) inhibitors have been shown to have a protective effect on cardiovascular disease. Whether DPP-4 inhibitors may be beneficial in the treatment of AAA is unclear. We investigated the effects of DPP-4 inhibitor sitagliptin on the angiotensin II (Ang II)-infused AAA formation in apoE-deficient (apoE-/-) mice. Mice with induced AAA were treated with placebo or 2.5, 5 or 10 mg/kg/day sitagliptin. Ang II-infused apoE-/- mice exhibited a 55.6% incidence of AAA formation, but treatment with sitagliptin decreased AAA formation. Specifically, administered sitagliptin in Ang II-infused mice exhibited decreased expansion of the suprarenal aorta, reduced elastin lamina degradation of the aorta, and diminished vascular inflammation by macrophage infiltration. Treatment with sitagliptin decreased gelatinolytic activity and apoptotic cells in aorta tissues. Sitaglipitn, additionally, was associated with increased levels of plasma active glucagon-like peptide-1 (GLP-1). In vitro studies, GLP-1 decreased reactive oxygen species (ROS) production, cell migration, and MMP-2 as well as MMP-9 activity in Ang II-stimulated monocytic cells. The results conclude that oral administration of sitagliptin can prevent abdominal aortic aneurysm formation in Ang II-infused apoE-/-mice, at least in part, by increasing of GLP-1 activity, decreasing MMP-2 and MMP-9 production from macrophage infiltration. The results indicate that sitagliptin may have therapeutic potential in preventing the development of AAA.

show abstract

“…AAA growth is progressive, and currently surgical intervention represents the only form of therapy for the condition. AAA rupture is a significant cause of mortality in the elderly and represents a condition with no effective medical therapy, and surgical intervention itself is associated with a 1–7% risk of death [3, 4]. With an anticipated increase in prevalence in AAA as a result of an aging population, there has been a surge in current research to develop novel medical treatments aimed at reducing the formation and progression of AAAs.…”

Section: Introductionmentioning

confidence: 99%

A Novel Histone Deacetylase Inhibitor Reduces Abdominal Aortic Aneurysm Formation in Angiotensin II-Infused Apolipoprotein E-Deficient Mice

Vinh¹,

Gaspari²,

Liu

et al. 2007

J Vasc Res

View full text Add to dashboard Cite

Background/Aims: Aberrant expression of components of the matrix metalloproteinase (MMP) enzyme system is implicated in abdominal aortic aneurysm (AAA) formation. We aimed to investigate the influence of a novel histone deacetylase (HDAC) inhibitor (HDACi) metacept-1 (MCT-1), previously documented to reduce MMP expression, on HDAC activity and MMP expression in aortic smooth muscle cells and the in vivo incidence of AAAs. Methods: Western blot and gelatin zymography were used to determine HDAC activity and MMP-2 expression and activity in rat (rVSMCs) and human aortic vascular smooth muscle cells (hVSMCs) in vitro. In vivo AAAs were generated using apolipoprotein E-deficient mice infused with angiotensin (Ang) II. Immunohistochemistry detected MMP-2 and -9 expression in AAA tissue samples. Results: In vitro, MCT-1 inhibited HDAC activity in rVSMCs, and MMP-2 expression and proteolytic activity in hVSMCs.In vivo, Ang II treatment alone exhibited an AAA incidence of 84%. Doxycycline decreased the incidence of AAAs to 50%. Importantly, MCT-1 reduced AAA incidence to approximately 44%. MMP-2 and -9 immunoreactivity was reduced in MCT-1-treated aortic tissue. Conclusion: The novel HDACi MCT-1 inhibits MMP expressionand AAA incidence suggesting this compound may warrant further investigation in the context of AAA biology.

show abstract

A Comparison of the Mortality Rate After Elective Repair of Aortic Aneurysms Detected Either by Screening or Incidentally

Abstract: men with a screen-detected AAA had a lower mortality rate after elective repair than in those detected incidentally; lower preoperative physiology scores suggested they were fitter (as well as younger). In this study POSSUM analysis more accurately predicted outcome than P-POSSUM.

Cited by 22 publications

References 13 publications

Abdominal aortic aneurysm

Abdominal aortic aneurysm

Dipeptidyl Peptidase-4 Inhibitor Decreases Abdominal Aortic Aneurysm Formation through GLP-1-Dependent Monocytic Activity in Mice

A Novel Histone Deacetylase Inhibitor Reduces Abdominal Aortic Aneurysm Formation in Angiotensin II-Infused Apolipoprotein E-Deficient Mice

Contact Info

Product

Resources

About