A COMPARISON OF THE OXYGEN DISSOCIATION CURVES OF THE BLOODS OF MATERNAL AND FETAL GOATS AT VARIOUS pHs

Hellegers, André E.; Meschia, Giacomo; Prystowsky, Harry; Wolkoff, A. Stark; Barron, Donald H.

doi:10.1113/expphysiol.1959.sp001393

Cited by 36 publications

(9 citation statements)

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“…Huisman et al [1958] have presented evidence that the oxygen affinity of the blood of individuals of a Dutch breed, Texel, can be correlated with the presence of one or the other of two electrophoretically distinguishable hemoglobins and, further, that the oxygen affinities of the two hemoglobins in solution differ in the same way as the oxygen dissociation curves of the whole blood, i.e., the blood with the higher oxygen affinity contains the hemoglobin with the higher affinity. A similar correlation between the oxygen affinity of the whole blood and that of the hemoglobin it contains has not been observed in a variety of human bloods [Allen et al, 1953;Prystowsky et al, 1959;Schruefer et al, 1962].…”

supporting

confidence: 59%

Hemoglobin Characteristics and the Oxygen Affinity of the Bloods of Dorset Sheep

et al. 1963

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Two electrophoretically distinguishable hemoglobins have been identified in the bloods of pure bred Dorset sheep. The oxygen affinity of the whole blood, as judged by the oxygen pressure required to half-saturate its hemoglobin at 380 C. and pH 7-4 has been shown to be correlated with the relative proportions of the two hemoglobins. Blood containing only the hemoglobin which moves the more rapidly in the electrophoretic field has a higher oxygen affinity than the one with the lower mobility. The two hemoglobins appear to differ in the amino acid sequence in the beta chain of the molecule.DIURING a study of the adaptations made by pregnant ewes and their fetuses to the low oxygen pressure of high altitude, oxygen dissociation curves of bloods of a number of sheep of Merino stock were prepared at Morococha, Peru in the autumn of 1958 . The results demonstrated a lack of uniformity in the oxygen affinities of the bloods of the individual ewes, for some were half-saturated at an oxygen tension of 31.5-33 mm. Hg at plasma pH 7.4 and 380 C., whereas to saturate others to the same degree, in the same circumstances, required an oxygen tension of 36-38 mm. A similar study on the bloods of pedigree Dorsets at sea level [Meschia et al., 1961 b] revealed a comparable variation in their oxygen affinities.Differences in the oxygen affinities of the bloods of individuals of the same species, when compared at the same plasma pH, could be the result of: (1) differences in their hemoglobins, (2) differences in the concentrations of other solutes within the red cell (intracellular pH, etc.) or (3) a combination of the two circumstances. These factors by their effects on the oxygen affinity of whole blood can play an important role in the regulation of the circulation and respiration of the individual. Yet there is at present no agreement of the relative importance of these possible sources of variation.In an effort to learn something of the relative importance of the structure

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confidence: 59%

Hemoglobin Characteristics and the Oxygen Affinity of the Bloods of Dorset Sheep

et al. 1963

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“…Hematologic studies were performed by standard techniques, and oxygen dissociation curves were constructed by the method of Hellegers, Meschia, Prystowsky, Wolkoff, and Barron (19).…”

Section: Methodsmentioning

confidence: 99%

Effect of 2,3-diphosphoglycerate on oxygen affinity of blood in sickle cell anemia

Charache¹,

Grisolı́a²,

Fiedler³

et al. 1970

J. Clin. Invest.

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115

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“…Blood oxygen dissociation curves were determined by the manometric method of Hellegers and his associates (14) .1 Details of these analyses will be published elsewhere (12). Electropho-resis, alkali denaturation, dissociation and recombination experiments, and incubation with oxidant dyes were performed as previously described (15).…”

Section: Methodsmentioning

confidence: 99%

Polycythemia associated with a hemoglobinopathy.

Charache¹,

Weatherall²,

Clegg³

1966

J. Clin. Invest.

222

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A COMPARISON OF THE OXYGEN DISSOCIATION CURVES OF THE BLOODS OF MATERNAL AND FETAL GOATS AT VARIOUS pHs

Cited by 36 publications

References 1 publication

Hemoglobin Characteristics and the Oxygen Affinity of the Bloods of Dorset Sheep

Hemoglobin Characteristics and the Oxygen Affinity of the Bloods of Dorset Sheep

Effect of 2,3-diphosphoglycerate on oxygen affinity of blood in sickle cell anemia

Polycythemia associated with a hemoglobinopathy.

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