A comparison of the pattern of occurrence of breast cancer in Nigerian and British women

Gukas, Isaac G. D.; Jennings, Barbara; Mandong, BM; Manasseh, A N; Harvey, Ian; Leinster, Sam

doi:10.1016/j.breast.2005.02.003

Cited by 28 publications

(24 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The breast cancer is the most common cancer in women worldwide and the commonest cause of cancer death in women [1,2]. predominantly in the industrialized countries [3].…”

Section: Introductionmentioning

confidence: 99%

The incidence, age at diagnosis of breast cancer in the Iraqi Kurdish population and comparison to some other countries of Middle-East and West

Karim¹,

Ghalib

Mohammed

et al. 2015

International Journal of Surgery

View full text Add to dashboard Cite

show abstract

“…The breast cancer is the most common cancer in women worldwide and the commonest cause of cancer death in women [1,2]. predominantly in the industrialized countries [3].…”

Section: Introductionmentioning

confidence: 99%

The incidence, age at diagnosis of breast cancer in the Iraqi Kurdish population and comparison to some other countries of Middle-East and West

Karim¹,

Ghalib

Mohammed

et al. 2015

International Journal of Surgery

View full text Add to dashboard Cite

show abstract

“…Data from the Second All Breast Cancer Report showed that 45% of breast cancer in black women occurs between the ages of 30 and 49 years, compared with only 18% in the white population [28]. A small study comparing the age-specific incidence of breast cancer in Jos in Nigeria (n = 150) and Norfolk in the UK (n = 668) showed a mean age at presentation of 43.1 and 64 years, respectively [29]. Overall, Nigeria has a larger population than the UK and a shorter life expectancy (for women, 52.2 and 80.7 years, respectively).…”

Section: Discussionmentioning

confidence: 99%

Histological Features and Tissue Microarray Taxonomy of Nigerian Breast Cancer Reveal Predominance of the High-Grade Triple-Negative Phenotype

Titloye

Foster

et al. 2016

Pathobiology

View full text Add to dashboard Cite

Introduction: Little is known about the biology, molecular profile and hence optimal treatment of African Nigerian breast cancer. The aim of this work, therefore, was to characterize the histology and molecular profile of Nigerian breast cancer. Methods: Breast carcinomas from women at 6 centres of similar tribal origin in Nigeria were reviewed and assembled into tissue microarrays (TMAs), and sections were stained for hormone receptors, i.e. estrogen receptor (ER)α, ERβ1, ERβ progesterone receptor (PR) and androgen receptor, cyclin D, HER2, Ki67 and cytokeratins (CKs), i.e. CK5/6 and CK14 (basal) and CK18 and 19 (luminal). Results: A total of 835 tumours were analysed. The mean age at diagnosis was 48.62 ± 12.41 years. The most common histological subtype was ductal NST (no-special-type) carcinoma (87.3%). Over 90% of the tumours were grade 2 or 3. The predominant molecular phenotype was the non-basal, triple-negative type (47.65%) followed by the HER2-positive group (19.6%). The percentage of ER-, PR- and HER2-positive tumours was 22.4, 18.9 and 18.8%, respectively. Conclusion: Nigerian breast cancer predominantly has a high-grade, triple-negative profile. It occurs at a younger age and bears similarities at the molecular level to pre-menopausal breast cancer in white women, with remarkably lower levels of ERβ expression. The early presentation and histological and molecular phenotype may explain the poor prognosis, and tailoring treatment strategies to target this unique profile are required.

show abstract

“…The few published epidemiologic studies have suggested that breast cancer exhibits specific features in this region of the world compared to the USA and Europe [9,10,11,12], as breast cancer in African women is reported to usually occur at a younger age and to present more aggressive features, such as high-grade tumors, estrogen receptor (ER)-negative and/or triple-negative phenotypes [ER–/progesterone receptor (PR)–/human epidermal growth factor receptor 2 (HER2)–] [13,14,15,16]. However, the high frequency of ER-negative or triple-negative tumors in Africa has recently been questioned [2], as data derived from some studies have been considered to be possibly related to technical artefacts and more systematic studies have provided contradictory results [2].…”

Section: Introductionmentioning

confidence: 99%

High Incidence of Triple-Negative Tumors in Sub-Saharan Africa: A Prospective Study of Breast Cancer Characteristics and Risk Factors in Malian Women Seen in a Bamako University Hospital

Antoine

Dembélé

et al. 2012

Oncology

View full text Add to dashboard Cite

Objective: Few studies have been conducted on breast cancer in Sub-Saharan Africa and their results have been suspected to be impaired by artefacts. This prospective study was designed to determine tumor and patient characteristics in Mali with control of each methodological step. These data are necessary to define breast cancer treatment guidelines in this country. Methods: Clinical and tumor characteristics and known risk factors were obtained in a consecutive series of 114 patients. Each technical step for the determination of tumor characteristics [histology, TNM, grade, estrogen (ER) and progesterone receptors (PR), HER2, and Ki67] was controlled. Results: Patients had a mean age of 46 years. Most tumors were invasive ductal carcinomas (94%), T3-T4 (90%) with positive nodes (91%), grade III (78%), and ER (61%) and PR (72%) negative. HER2 was overexpressed in 18% of cases. The triple-negative subgroup represented 46%, displaying a particularly aggressive pattern (90% grade III; 88% Ki67 >20%). Conclusion: This study demonstrates the high incidence of aggressive triple-negative tumors in Mali. Apart from a higher prevalence of premenopausal women, no significant difference in risk factors was observed between triple-negative tumors and other tumors. The hormonal therapy systematically prescribed therefore needs to be revised in light of this study.

show abstract

A comparison of the pattern of occurrence of breast cancer in Nigerian and British women

Cited by 28 publications

References 14 publications

The incidence, age at diagnosis of breast cancer in the Iraqi Kurdish population and comparison to some other countries of Middle-East and West

The incidence, age at diagnosis of breast cancer in the Iraqi Kurdish population and comparison to some other countries of Middle-East and West

Histological Features and Tissue Microarray Taxonomy of Nigerian Breast Cancer Reveal Predominance of the High-Grade Triple-Negative Phenotype

High Incidence of Triple-Negative Tumors in Sub-Saharan Africa: A Prospective Study of Breast Cancer Characteristics and Risk Factors in Malian Women Seen in a Bamako University Hospital

Contact Info

Product

Resources

About