A comparison of the physicochemical properties and a sensory test of Acyclovir creams

Inoue, Yutaka; Furuya, Kayoko; Matumoto, Miruto; Murata, Ikuo; Kimura, Masayuki; Kanamoto, Ikuo

doi:10.1016/j.ijpharm.2012.06.023

Cited by 20 publications

(14 citation statements)

References 19 publications

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“…Results of the assays of TC and ACV are shown in Table 2. The ACV content of ACV-cr has been found to be 95% or higher (Inoue et al, 2012 A TC-o is reported to have a decline in TC content and a decline in antibacterial activity when combined with an ointment containing sodium hydroxide (Kawamoto et al, 2008). A closer look at additives contained in the ACV-cr indicates that ACV-A and ACV-C contain additives with Na salts (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…There are both brand-name and generic ACV-cr. The current authors have studied the physicochemical properties of ACV-cr and noted differences in the types of additives and differences in their water content, viscosity, elasticity, and emulsification (Inoue et al, 2012). Viscoelasticity is one reported way to assess the physical properties of a semisolid substance, and the viscoelasticity of conditioners and ointments has been assessed (Moji et al, 2002;Hong et al, 2010;Kobayashi et al, 1982).…”

Section: Introductionmentioning

confidence: 99%

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Assessment of the physical properties and stability of mixtures of tetracycline hydrochloride ointment and acyclovir cream

Inoue

Furuya

Maeda

et al. 2013

International Journal of Pharmaceutics

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In dermatology, ointments are often mixed as part of drug therapy, but mixing often leads to incompatibility. Three combinations of tetracycline ointment (TC-o) and acyclovir cream (ACV-cr) were prepared at a TC-o:ACV-cr ratio of 1:1 using a brand-name ACV-cr and two generic ACV-cr (samples TC-o+ACV-A, TC-o+ACV-B, and TC-o+ACV-C). Microscopic examination revealed separation in TC-o+ACV-C. Viscosity and elasticity measurement indicated that the storage modulus (G') and loss modulus (G″) of each of the TC-o+ACV-cr mixtures behaved similarly to those of an ACV-cr and the loss tangent (tanδ) behaved similarly to that of a TC ointment. In addition, differences in the storage modulus (G') and loss modulus (G″) of the TC-o+ACV-cr mixtures were noted. To assess stability, each TC-o+ACV-cr mixture was stored away from direct sunlight at 25 °C and an RH of 84% and at 4 °C (in a refrigerator). HPLC revealed that the ACV content in each TC-o+ACV-cr mixture remained at 95-105% for up to 14 days under both sets of storage conditions. A decline in TC content in each TC-o+ACV-cr mixture was not noted with storage at 4 °C but was noted over time with storage at 25 °C and an RH of 84%. In addition, significant differences in the percent decline in TC content in each TC-o+ACV-cr mixture occurred with storage at 25 °C and an RH of 84%. Thus, differences in physical properties and stability may occur when combining brand-name and generic drugs, and temperature and humidity may be the cause of the TC-o's incompatibility.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of the physical properties and stability of mixtures of tetracycline hydrochloride ointment and acyclovir cream

Inoue

Furuya

Maeda

et al. 2013

International Journal of Pharmaceutics

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“…CR6 was comparatively harder than CR4 which is because of the presence of higher concentration of GMS. Adhesiveness, which is defined as the maximum force required for overcoming the attractive force between any surface and sample (cream), was characterized as a measure for stickiness of the sample [25, 37]. Comparatively, CR4 required higher force (1.43 ± 0.05–1.83 ± 0.11 g) than CR6 (0.63 ± 0.05–0.73 ± 0.05 g) in adhesiveness test; hence CR4 was found to be more adhesive.…”

Section: Discussionmentioning

confidence: 99%

Enrichment, Development, and Assessment of Indian Basil Oil Based Antiseptic Cream Formulation Utilizing Hydrophilic-Lipophilic Balance Approach

Yadav

Meher

Pandey

et al. 2013

BioMed Research International

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The present work was aimed to develop an antiseptic cream formulation of Indian basil oil utilizing hydrophilic-lipophilic balance approach. In order to determine the required-hydrophilic lipophilic balance (rHLB) of basil oil, emulsions of basil oil were prepared by phase inversion temperature technique using water, Tween 80, and Span 80. Formulated emulsions were assessed for creaming (BE9; 9.8, BE10; 10.2), droplet size (BE18; 3.22 ± 0.09 μm), and turbidity (BE18; 86.12 ± 2.1%). To ensure correctness of the applied methodology, rHLB of light liquid paraffin was also determined. After rHLB determination, basil oil creams were prepared with two different combinations of surfactants, namely, GMS : Tween 80 (1 : 3.45) and SLS : GMS (1 : 3.68), and evaluated for in vitro antimicrobial activity, skin irritation test, viscosity and consistency. The rHLB of basil oil and light liquid paraffin were found to be 13.36 ± 0.36 and 11.5 ± 0.35, respectively. Viscosity, and consistency parameters of cream was found to be consistent over 90 days. Cream formulations showed net zone of growth inhibition in the range of 5.0–11.3 mm against bacteria and 4.3–7.6 mm against fungi. Primary irritation index was found to be between 0.38 and1.05. Conclusively stable, consistent, non-irritant, enriched antiseptic basil oil cream formulations were developed utilizing HLB approach.

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“…They suggested that the differences in the spreadability of the brand name and generic products might have been caused by species and quality differences in the ointment bases and additives used. Another study found differences in the viscosity and elasticity of brand name acyclovir creams and two generic products, which caused them to feel different [6] . Furthermore, differences in the concentration of solubilized steroids in white petrolatum were detected by Ohtani et al [1] , which seemed to induce changes in their physiological activities.…”

Section: Introductionmentioning

confidence: 99%

Differences in the rheological properties and mixing compatibility with heparinoid cream of brand name and generic steroidal ointments: The effects of their surfactants

Kitagawa

Yutani

Kodani

et al. 2016

Results in Pharma Sciences

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Most steroidal ointments contain propylene glycol (PG) and surfactants, which improve the solubility of corticosteroids in white petrolatum. Surfactants aid the uniform dispersal of PG within white petrolatum. Since the surfactants used in generic ointments are usually different from those used in brand name ointments, we investigated the effects of surfactants on the rheological properties of three brand name ointments and six equivalent generic ointments. We detected marked differences in hardness, adhesiveness, and spreadability among the ointments. Further examinations of model ointments consisting of white petrolatum, PG, and surfactants revealed that the abovementioned properties, especially hardness and adhesiveness, were markedly affected by the surfactants. Since steroidal ointments are often admixed with moisturizing creams prior to use, we investigated the mixing compatibility of the ointments with heparinoid cream and how this was affected by their surfactants. We found that the ointments containing glyceryl monostearate demonstrated good mixing compatibility, whereas those containing non-ionic surfactants with polyoxyethylene chains exhibited phase separation. These results were also consistent with the findings for the model ointments, which indicates that the mixing compatibility of steroidal ointments with heparinoid cream is determined by the emulsifying capacity of the surfactants in their oily bases.

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A comparison of the physicochemical properties and a sensory test of Acyclovir creams

Cited by 20 publications

References 19 publications

Assessment of the physical properties and stability of mixtures of tetracycline hydrochloride ointment and acyclovir cream

Assessment of the physical properties and stability of mixtures of tetracycline hydrochloride ointment and acyclovir cream

Enrichment, Development, and Assessment of Indian Basil Oil Based Antiseptic Cream Formulation Utilizing Hydrophilic-Lipophilic Balance Approach

Differences in the rheological properties and mixing compatibility with heparinoid cream of brand name and generic steroidal ointments: The effects of their surfactants

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