A comparison of the therapeutic effect of amputation and roentgen radiation on C3H/HES osteogenic sarcoma

Kalenak, Alexander; Rogers, Charles C.

doi:10.1016/0022-4804(72)90079-0

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1975

1986

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Cited by 4 publications

(2 citation statements)

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“…The Durra osteosarcoma, which arose spontaneously in the tail of a C3H mouse in 1955 (Kalenak and Rogers, 1972), has been maintained by serial transplantation in C3H mice. The tumor was obtained from Dr. Hiramota of the University of Alabama.…”

Section: Tissue Culture Cell Linesmentioning

confidence: 99%

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Detection of antibodies bound to tumor cell surface antigens with radioiodinated Staphylococcus aureus protein A (SPA)

Nayak

Knotts

Drogemuller

et al. 1979

Cancer Immunol Immunother

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Section: Tissue Culture Cell Linesmentioning

confidence: 99%

“…In the present paper, we describe a modification of the technique of Brown et al (1977). We used a mouse osteosarcoma (Kalenak and Rogers, 1972) model in order to develop optimum conditions for the performance of the test. These modifications greatly simplify the assay, so that multiple serum samples can be tested simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Detection of antibodies bound to tumor cell surface antigens with radioiodinated Staphylococcus aureus protein A (SPA)

Nayak

Knotts

Drogemuller

et al. 1979

Cancer Immunol Immunother

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A laboratory model for the study of the immunobiology of osteosarcoma

Friedlaender

Mitchell

1975

Cancer

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Inoculation of Moloney sarcoma virus into the marrow cavity of the tibia of newborn Wistar-Lewis rats resulted in the appearance of a n initially localized osteosarcoma in 97.7% of these animals. At least 77.9% of the rats developed lung metastases and died, usually within 6 weeks of inoculation. The remaining 22.1% showed regression of disease after initial growth of the tumor. Tumor cells were maintained in tissue culture and used as target cells for a visual and isotopic ('H-thymidine or '"IUdR) microcytotoxicity assay. Cell-mediated immunity could be measured by these methods throughout the course of the illness in animals with progressive disease as well as in those whose tumors eventually regressed. The presence of serum factors capable of modifying the level of CMI was documented. This Moloney-sarcoma-virus-induced rat osteosarcoma and human osteoaarcoma thus appear to have several basic pathologic and immunologic similarities. The model may be useful for studying the effects of a variety of treatment protocols upon the clinical course and immune response to osteosarcoma.

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Osteosarcoma

Green¹

1985

Diagnosis and Management of Malignant Solid Tumors in Infants and Children

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A comparison of the therapeutic effect of amputation and roentgen radiation on C3H/HES osteogenic sarcoma

Cited by 4 publications

References 12 publications

Detection of antibodies bound to tumor cell surface antigens with radioiodinated Staphylococcus aureus protein A (SPA)

Detection of antibodies bound to tumor cell surface antigens with radioiodinated Staphylococcus aureus protein A (SPA)

A laboratory model for the study of the immunobiology of osteosarcoma

Osteosarcoma

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