Most approaches to psychotherapy integration assume that any integrated theory will rest on a solid empirical basis. Recent reconceptualizations of the research process, however, indicate that knowledge of research findings alone cannot provide such a foundation. Most critically, method effects influence the results of every study to the extent that the validity of theoretical propositions is tenuous without reference to the underlying methodological conditions. While researchers vary methodology during prestudies to enhance the possibility of finding statistically significant results, the details of such prestudies are typically unreported, and methodological conditions in general are underreported in all psychological research. In psychotherapy outcome studies, altering methodological conditions changes findings and subsequent conclusions. Assessment method, source of data, and the specific operation chosen, for example, have been demonstrated to influence degree of apparent change. Additional examples illustrate how differences in measures' change sensitivity can interact with participant characteristics to produce a dispersion of Effect Sizes (ESs) in response to psychosocial interventions. Prevailing approaches to psychotherapy integration, focusing on theoretical propositions based on empirical findings without reference to methodology, have produced conflicting results and little consensus beyond recognition of the need for additional efforts at integration. Adding a methodological emphasis should enhance detection of constructs, detection of relations among constructs, and replication of psychotherapy research findings to strengthen subsequent work on psychotherapy integration.