A comparison of ultrasonic beams for thermal treatment of ocular tumors

Lizzi, Frederic L.; Deng, Cheri X.; Lee, Paul; Rosado, A.; Silverman, Ronald H.; Coleman, D. Jackson

doi:10.1016/s0929-8266(99)00011-7

Cited by 29 publications

(13 citation statements)

References 13 publications

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“…4 Since then, it has been evaluated extensively in animal 5,6 and human 7 brains and in the kidney, prostate, liver, bladder, 8–11 and eye 12 within clinical trials. Clinical acceptance, however, was hampered because of the difficulty in controlling the focal spot position, defining the beam target precisely, and coping with the lack of feedback about thermal damage.…”

Section: Magnetic Resonance–guided Focused Ultrasound Surgery For Trementioning

confidence: 99%

MR Imaging–Guided Interventions in the Genitourinary Tract: An Evolving Concept

Fennessy

Tuncalı

Morrison

et al. 2010

Magnetic Resonance Imaging Clinics of North America

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Section: Magnetic Resonance–guided Focused Ultrasound Surgery For Trementioning

confidence: 99%

MR Imaging–Guided Interventions in the Genitourinary Tract: An Evolving Concept

Fennessy

Tuncalı

Morrison

et al. 2010

Magnetic Resonance Imaging Clinics of North America

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“…Because of the non-invasive characteristic of this thermal ablation technique, HIFU has been investigated in various fields as a therapeutic technique. The application of this technique includes hemostasis [2], neurolysis of peripheral nerves for the treatment of spasticity and pain [3], the treatment of atrial fibrillation [4], and the treatment of tumors in different organs [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

A backscatter-based method for treatment targeting in the application of High Intensity Focused Ultrasound

Zheng

Vaezy

2008

2008 IEEE Ultrasonics Symposium

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High Intensity Focused Ultrasound (HIFU) has been investigated as a non-invasive ablation method for morbid tissue in various diseases. It is of great importance to know where the focus would be in HIFU treatment planning to ensure that only the desired tissue is ablated while sparing normal tissue. We investigated a method for HIFU targeting based on the change in radiofrequency (RF) signals at pre-ablative HIFU intensity levels. In ex vivo experiment, HIFU was applied to chicken tissue at low intensity levels for 5 seconds, during which no tissue damage was observed. RF data were collected during this period and the amplitude change was analyzed. High intensity was then applied to induce lesion in tissue and hyperecho in B-mode images. Focus estimated from RF data was compared with that obtained from hyperechoic region. Results showed that RF amplitude of the focal region increased immediately after the start of HIFU exposure, even at pre-ablative intensity levels. The difference between focus locations based on RF data and B-mode images was 1.92 ± 1.02 mm (mean ± standard deviation). No statistically significant difference was found between focus coordinates in the axial and lateral dimensions (axial: p = 0.50 and lateral: p = 0.07). The increasing rate in RF amplitude was shown to be a signature of HIFU focus and could be used for HIFU treatment planning.

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“…14 This technique utilizes the radio-frequency (rf) echo signals measured directly at conventional clinical ultrasound probes. It has proven to be useful in the diagnosis of diseases in various organs, ranging from eye, 15,16 breast, 17,18 prostate, 19 kidney and liver, 20,21 to plaque 22,23 and lymph nodes. 24 We have extended this 1-D technique to 2-D using the same clinical data to more fully characterize tissue microstructures in terms of their physical properties.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic tissue characterization via 2‐D spectrum analysis: Theory and in vitro measurements

Liu¹,

Lizzi²,

Ketterling³

et al. 2007

Medical Physics

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A theoretical model is described for application in ultrasonic tissue characterization using a calibrated 2-D spectrum analysis method. This model relates 2-D spectra computed from ultrasonic backscatter signals to intrinsic physical properties of tissue microstructures, e.g., size, shape, and acoustic impedance. The model is applicable to most clinical diagnostic ultrasound systems. Two experiments employing two types of tissue architectures, spherical and cylindrical scatterers, are conducted using ultrasound with center frequencies of 10 and 40 MHz, respectively. Measurements of a tissue-mimicking phantom with an internal suspension of microscopic glass beads are used to validate the theoretical model. Results from in vitro muscle fibers are presented to further elucidate the utility of 2-D spectrum analysis in ultrasonic tissue characterization.

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A comparison of ultrasonic beams for thermal treatment of ocular tumors

Cited by 29 publications

References 13 publications

MR Imaging–Guided Interventions in the Genitourinary Tract: An Evolving Concept

MR Imaging–Guided Interventions in the Genitourinary Tract: An Evolving Concept

A backscatter-based method for treatment targeting in the application of High Intensity Focused Ultrasound

Ultrasonic tissue characterization via 2‐D spectrum analysis: Theory and in vitro measurements

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