A compartment-based myocardial density approach helps to solve the native T1 vs. ECV paradox in cardiac amyloidosis

Chamling, Bishwas; Bietenbeck, Michael; Drakos, Stefanos; Korthals, Dennis; Vehof, Volker; Stalling, Philipp; Meier, Claudia; Yılmaz, Ali

doi:10.1038/s41598-022-26216-9

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…ECV values were obtained from pre- and post-contrast T1 map indexes of hematocrit. Relative intracellular volume was calculated using the formula [1 – ECV]; “total intracellular mass” was calculated with the formula [relative intracellular volume × total LV myocardial volume × myocardial density], using the well-known myocardial density value of 1.055 g/mL for human; and “total extracellular mass” with the formula [ECV × total LV myocardial volume × myocardial density], using a different myocardial density value of 1.38 g/mL for extracellular infiltrative disease, as described in the previous work [ 15 ]. The LV LGE patterns were graded according to the Moon criteria as follows: 1 = none, 2 = subendocardial, and 3 = transmural [ 6 ].…”

Section: Methodsmentioning

confidence: 99%

Light-Chain Cardiac Amyloidosis: Cardiac Magnetic Resonance for Assessing Response to Chemotherapy

Guo,

Li,

Gao

et al. 2024

Korean J Radiol

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Objective Cardiac magnetic resonance (CMR) is a diagnostic tool that provides precise and reproducible information about cardiac structure, function, and tissue characterization, aiding in the monitoring of chemotherapy response in patients with light-chain cardiac amyloidosis (AL-CA). This study aimed to evaluate the feasibility of CMR in monitoring responses to chemotherapy in patients with AL-CA. Materials and Methods In this prospective study, we enrolled 111 patients with AL-CA (50.5% male; median age, 54 [interquartile range, 49–63] years). Patients underwent longitudinal monitoring using biomarkers and CMR imaging. At follow-up after chemotherapy, patients were categorized into superior and inferior response groups based on their hematological and cardiac laboratory responses to chemotherapy. Changes in CMR findings across therapies and differences between response groups were analyzed. Results Following chemotherapy (before vs. after), there were significant increases in myocardial T2 (43.6 ± 3.5 ms vs. 44.6 ± 4.1 ms; P = 0.008), recovery in right ventricular (RV) longitudinal strain (median of -9.6% vs. -11.7%; P = 0.031), and decrease in RV extracellular volume fraction (ECV) (median of 53.9% vs. 51.6%; P = 0.048). These changes were more pronounced in the superior-response group. Patients with superior cardiac laboratory response showed significantly greater reductions in RV ECV (-2.9% [interquartile range, -8.7%–1.1%] vs. 1.7% [-5.5%–7.1%]; P = 0.017) and left ventricular ECV (-2.0% [-6.0%–1.3%] vs. 2.0% [-3.0%–5.0%]; P = 0.01) compared with those with inferior response. Conclusion Cardiac amyloid deposition can regress following chemotherapy in patients with AL-CA, particularly showing more prominent regression, possibly earlier, in the RV. CMR emerges as an effective tool for monitoring associated tissue characteristics and ventricular functional recovery in patients with AL-CA undergoing chemotherapy, thereby supporting its utility in treatment response assessment.

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Section: Methodsmentioning

confidence: 99%

Light-Chain Cardiac Amyloidosis: Cardiac Magnetic Resonance for Assessing Response to Chemotherapy

Guo,

Li,

Gao

et al. 2024

Korean J Radiol

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“…Therefore, in order to imitate the basic properties of the heart tissue, such as elasticity and strength, the MJ technique was employed in the present work. According to the manufacturer's datasheet, the composite material with the closest properties to the heart tissue [10,35] is the RWT-ENT A50™. RWT-ENT A50™ is a composite material consisting mainly of VisiJet CE-NT™ (elastomer material) and small portions of VisiJet CR-CL 200™ (rigid material).…”

Section: Additive Manufacturing and 3d Scanning Proceduresmentioning

confidence: 99%

Examination of a Human Heart utilizing Virtual Reality, Additive Manufacturing and Computational Technologies

Charalampous

Kladovasilakis

Zoumaki

et al. 2023

Preprint

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Purpose In this paper, an innovative approach concerning the investigation of the human heart is introduced employing state-of-the-art technologies. The presented technological tools aim in the creation of an innovative digital environment, where gaining surgical experience and developing pre-operative strategies could be achieved without the risk and anxiety of an actual heart surgery. Methods Sophisticated algorithms were developed in order to automatically reconstruct a 3D model of a human heart based on DICOM data and to segment the main parts that constitutes it. Taking into account the reconstructed 3D model, a diagnosis of the examined patient can be derived, where in the present study a Coarctation of the Aorta (CoA) clinical case was inspected. In addition, numerical approaches were considered that are able to simulate flows on complex shapes. Finally, a physical model was 3D printed via the MultiJet 3D Printing (MJP) process utilizing flexible materials. Results The outcomes of the computation analysis coupled with the automatically reconstructed and segmented patient-specific 3D model are inserted in a Virtual Reality (VR) environment, where the clinicians can visualize the blood flow at the vessel walls and train on real-life medical scenarios, enhancing that way the procedural understanding prior to the actual operation. Moreover, the 3D printed heart possesses an adequate mechanical response replicating the mechanical properties as well as the geometrical characteristics of the investigated human heart. Conclusions The present study introduced a robust software module for inspecting human hearts, aiding that way the medical doctors on the optimal preoperative assessment of patients with heart diseases using as input only the DICOM data of the examined patient.

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“…Therefore, in order to imitate the basic properties of heart tissue, such as elasticity and strength, the MJ technique was employed in the present work. According to the manufacturer's datasheet, the composite material with the closest properties to heart tissue [11,38] is RWT-ENT A50™. RWT-ENT A50™ is a composite material consisting mainly of VisiJet CE-NT™ (elastomer material) and small portions of VisiJet CR-CL 200™ (rigid material).…”

Section: Additive Manufacturing and 3d Scanning Proceduresmentioning

confidence: 99%

Examination of a Human Heart Fabricating Its 3D-Printed Cardiovascular Model and Employing Computational Technologies

Charalampous,

Kladovasilakis,

Zoumaki

et al. 2023

Applied Sciences

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In this paper, an innovative approach concerning the investigation of the human heart is introduced, employing state-of-the-art technologies. In particular, sophisticated algorithms were developed to automatically reconstruct a 3D model of a human heart based on DICOM data and to segment the main parts that constitute it. Regarding the reconstructed 3D model, a diagnosis of the examined patient can be derived, whereas in the present study, a clinical case involving the coarctation of the aorta was inspected. Moreover, numerical approaches that are able to simulate flows on complex shapes were considered. Thereupon, the outcomes of the computation analysis coupled with the segmented patient-specific 3D model were inserted in a virtual reality environment, where the clinicians can visualize the blood flow at the vessel walls and train on real-life medical scenarios, enhancing their procedural understanding prior to the actual operation. The physical model was 3D-printed via the MultiJet 3D printing process utilizing materials possessing an adequate mechanical response replicating the mechanical properties and the geometrical characteristics of the human heart. The presented tools aim at the creation of an innovative digital environment, where gaining surgical experience and developing pre-operative strategies could be achieved without the risk and anxiety of actual surgery.

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A compartment-based myocardial density approach helps to solve the native T1 vs. ECV paradox in cardiac amyloidosis

Cited by 5 publications

References 26 publications

Light-Chain Cardiac Amyloidosis: Cardiac Magnetic Resonance for Assessing Response to Chemotherapy

Light-Chain Cardiac Amyloidosis: Cardiac Magnetic Resonance for Assessing Response to Chemotherapy

Examination of a Human Heart utilizing Virtual Reality, Additive Manufacturing and Computational Technologies

Examination of a Human Heart Fabricating Its 3D-Printed Cardiovascular Model and Employing Computational Technologies

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