A complementary-DNA-enhanced fiber-optic sensor based on microfiber-assisted Mach-Zehnder interferometry for biocompatible pH sensing

Wang, Yujia; Zhang, Hao; Cui, Yunxi; Duan, Shaoxiang; Lin, Wei; Liu, Bo

doi:10.1016/j.snb.2021.129516

Cited by 23 publications

(9 citation statements)

References 33 publications

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“…Dip 1 did not shift, while Dip 2 red shifted by 0.8 nm from 1562.2 nm to 1563 nm. This is because the interference spectrum here is caused by multimode interference, and the response of each peak to the changing external environment reflectivity index is not consistent, which has also been reported and explained in detail [ 3 , 38 ].…”

Section: Resultsmentioning

confidence: 92%

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Rapid-Response and Wide-Range pH Sensors Enabled by Self-Assembled Functional PAni/PAA Layer on No-Core Fiber

et al. 2022

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The measurement of pH has received great attention in diverse fields, such as clinical diagnostics, environmental protection, and food safety. Optical fiber sensors are widely used for pH sensing because of their great advantages. In this work, an optical fiber pH sensor is fabricated, by combining the merits of the multimode interference configuration and pH-sensitive polyaniline/polyacrylic acid (PAni/PAA) coatings, which was successfully in situ deposited on the no-core fiber (NCF) by the layer-by-layer (LBL) self-assembly method. The sensors’ performance was experimentally characterized when used for pH detection. It has a high sensitivity of 0.985 nm/pH and a great linear response in a universal pH range of 2–12. The response time and recovery time is measured to be less than 10 s. In addition, its temperature sensitivity is tested to be about 0.01 nm/°C with a low temperature crosstalk effect, which makes it promising for detecting pH in the liquid phase with temperature variation. The sensors also demonstrated easy fabrication, good stability, and repeatability, which are adapted to pH detection in most practical applications.

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Section: Resultsmentioning

confidence: 92%

“…As known, pH-conditions regulation is of significance in the fields of biochemical industry [ 1 ], food safety [ 2 ], disease diagnosis [ 3 ], environmental engineering [ 4 ], and so on. A slight variation in pH conditions will cause the failure of crucial processes within the above domains [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Rapid-Response and Wide-Range pH Sensors Enabled by Self-Assembled Functional PAni/PAA Layer on No-Core Fiber

et al. 2022

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“…Moreover, total internal reflection fluorescence microscopies (TIRF) (Lee et al, 2019;Peng et al, 2019), optical tweezers (Mitra and Ha, 2019;Shrestha et al, 2018), and nanopore technology (Wang et al, 2020b) are all great technologies that provide single-molecule level resolution. To date, more and more attempts using advanced high-resolution technologies to detect the signals carried by DNA have been reported (Hu et al, 2019;Li et al, 2020c;Mandal et al 2016Mandal et al , 2019Wang et al, 2021b). Although the major concept is still based on the engineering development of the instruments themselves, we believe that scientists will focus on the design of DNA biosensors more to better link the instruments with large-scale molecular biomarkers in living systems in the future.…”

Section: Dna Amplification-free Strategiesmentioning

confidence: 99%

Development of the DNA-based biosensors for high performance in detection of molecular biomarkers: More rapid, sensitive, and universal

Wang

Huang

et al. 2022

Biosensors and Bioelectronics

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“…Optical fiber sensor is one of the most superior optical sensors, so its combination with aptamers with easy synthesis, low cost, and strong stability has become a research focus. [41,[66][67][68] At present, many researchers have made remarkable and impressive achievements in this field, including the successful detections of ultra-low concentrations of disease markers in human body fluid samples, [17,18] the toxins, antibiotics, and microorganisms in food and drinking water; and the organic and inorganic contaminants in the environment. However, as far as we know, there are no comprehensive papers on the applications of optical fiber aptasensors.…”

Section: Introductionmentioning

confidence: 99%

Advances in Optical Fiber Aptasensor for Biochemical Sensing Applications

Zhang

et al. 2023

Adv Materials Technologies

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Optical fiber biochemical sensing technology, as a cutting‐edge, multidisciplinary, and universal sensing technology, is gradually becoming the research focus in the field of biochemical sensing. They enjoy distinctive characteristics such as high cost‐effectiveness, flexibility, resistance to electromagnetic interference, and small size and can be used to detect biochemical analytes at ultra‐low concentrations with ultra‐low sample consumption, even when these biochemical analytes are in hard‐to‐reach environments. An aptamer is a DNA or RNA oligonucleotide fragment with a high affinity for the target selected from random sequences. Due to their advantages of simple synthesis, low cost, good stability, good specificity, and strong affinity, they are gradually becoming ideal recognition elements and may replace antibodies as next‐generation target receptors. Therefore, aptamers, as functional materials, are integrated into optical fiber sensors, which are called optical fiber aptasensors, providing new opportunities for the construction of high‐performance and intelligent biochemical sensors. This article aims to review the recent research progress of fiber‐optic aptamer biochemical sensors, with a focus on their sensing mechanisms and applications. Finally, based on the existing deficiencies of fiber‐optic aptamer biochemical sensors and practical requirements, their future development trends are briefly discussed.

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A complementary-DNA-enhanced fiber-optic sensor based on microfiber-assisted Mach-Zehnder interferometry for biocompatible pH sensing

Cited by 23 publications

References 33 publications

Rapid-Response and Wide-Range pH Sensors Enabled by Self-Assembled Functional PAni/PAA Layer on No-Core Fiber

Rapid-Response and Wide-Range pH Sensors Enabled by Self-Assembled Functional PAni/PAA Layer on No-Core Fiber

Development of the DNA-based biosensors for high performance in detection of molecular biomarkers: More rapid, sensitive, and universal

Advances in Optical Fiber Aptasensor for Biochemical Sensing Applications

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