A Complex Expression Pattern of<i>Pax6</i>in the Pigeon Retina

Bandah, D.; Swissa, Tomer; Ben‐Shlomo, Gil; Banin, Eyal; Ofri, Ron; Sharon, Dror

doi:10.1167/iovs.06-1014

Cited by 14 publications

(8 citation statements)

References 35 publications

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“…For example, Pax6-5a has a role in inducing embryonic stem cells toward neural differentiation [95]. Each of the two isoforms can regulate its own set of target genes, but they also can have a cumulative effect on the expression of these genes [96,97]. Inami and co-authors (2016) have identified Pах6 transcripts of different classes in C. pyrrhogaster .…”

Section: Transcription Factors and Signal Molecules Characteristicmentioning

confidence: 99%

Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela

Grigoryan

Markitantova

2016

Biomedicines

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Many regeneration processes in animals are based on the phenomenon of cell reprogramming followed by proliferation and differentiation in a different specialization direction. An insight into what makes natural (in vivo) cell reprogramming possible can help to solve a number of biomedical problems. In particular, the first problem is to reveal the intrinsic properties of the cells that are necessary and sufficient for reprogramming; the second, to evaluate these properties and, on this basis, to reveal potential endogenous sources for cell substitution in damaged tissues; and the third, to use the acquired data for developing approaches to in vitro cell reprogramming in order to obtain a cell reserve for damaged tissue repair. Normal cells of the retinal pigment epithelium (RPE) in newts (Urodela) can change their specialization and transform into retinal neurons and ganglion cells (i.e., actualize their retinogenic potential). Therefore, they can serve as a model that provides the possibility to identify factors of the initial competence of vertebrate cells for reprogramming in vivo. This review deals mainly with the endogenous properties of native newt RPE cells themselves and, to a lesser extent, with exogenous mechanisms regulating the process of reprogramming, which are actively discussed.

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Section: Transcription Factors and Signal Molecules Characteristicmentioning

confidence: 99%

Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela

Grigoryan

Markitantova

2016

Biomedicines

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“…Pax6 is required for development of the pituitary (Estivill-Torrú s et al 2001). Amphioxus Pax4/6 has at least six isoforms, while for vertebrate Pax4 and Pax6 genes 5 and 13 splicing events, respectively, have been identified (Bandah et al 2007;Short and Holland 2008). Only two of four isoforms of Pax4 identified in the mouse are expressed in the developing pituitary (Rath et al 2009), indicative of the roles that differential expression of isoforms play in development.…”

Section: Alternatively Spliced Isoforms Are Differentially Expressed mentioning

confidence: 99%

Alternative Splicing in Development and Function of Chordate Endocrine Systems: A Focus on Pax Genes

Holland

Short²

2010

Integrative and Comparative Biology

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Genome sequencing has facilitated an understanding of gene networks but has also shown that they are only a small part of the answer to the question of how genes translate into a functional organism. Much of the answer lies in epigenetics-heritable traits not directly encoded by the genome. One such phenomenon is alternative splicing, which affects over 75% of protein coding genes and greatly amplifies the number of proteins. Although it was postulated that alternative splicing and gene duplication are inversely proportional and, therefore, have similar effects on the size of the proteome, for ancient duplications such as occurred in the Pax family of transcription factors, that is not necessarily so. The importance of alternative splicing in development and physiology is only just coming to light. However, several techniques for studying isoform functions both in vitro and in vivo have been recently developed. As examples of what is known and what is yet to be discovered, this review focuses on the evolution and roles of the Pax family of transcription factors in development and on alternative splicing of endocrine genes and the factors that regulate them.

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“…The PAX6 gene is part of the well-studied paired box gene family (PAX), which encodes transcription factors for many developmental processes and is subject to heavy alternative splicing [24-26]--41 transcripts were found in a gene in the pigeon retina [27]. The canonical isoform is characterized by an N-terminal paired domain followed by a linker, a paired-type homeodomain, and a (P/S/T)-rich C-terminal domain, yielding a 422-amino-acid protein (437 in zebrafish).…”

Section: Resultsmentioning

confidence: 99%

Inferring transcript phylogenies

Christinat

Moret

2012

BMC Bioinformatics

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Alternative splicing, an unknown mechanism 20 years ago, is now recognized as a major mechanism for proteome and transcriptome diversity, particularly in mammals--some researchers conjecture that up to 90% of human genes are alternatively spliced. Despite much research on exon and intron evolution, little is known about the evolution of transcripts.In this paper, we present a model of transcript evolution and an associated algorithm to reconstruct transcript phylogenies. The evolution of the gene structure--exons and introns--is used as basis for the reconstruction of transcript phylogenies. We apply our model and reconstruction algorithm on two well-studied genes, MAG and PAX6, obtaining results consistent with current knowledge and thereby providing evidence that a phylogenetic analysis of transcripts is feasible and likely to be informative.

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A Complex Expression Pattern ofPax6in the Pigeon Retina

Cited by 14 publications

References 35 publications

Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela

Cellular and Molecular Preconditions for Retinal Pigment Epithelium (RPE) Natural Reprogramming during Retinal Regeneration in Urodela

Alternative Splicing in Development and Function of Chordate Endocrine Systems: A Focus on Pax Genes

Inferring transcript phylogenies

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