This study reports the results of a single-arm, noncontrolled, Type 3 hybrid effectiveness-implementation trial evaluating virtual reality job interview training (VR-JIT) delivered in five preemployment transition programs comprising 15 schools, 10 administrators, 23 teachers, and 279 youth ages 16–21 years receiving special education preemployment transition services. Fidelity, expected implementation feasibility, and teacher and student acceptance of VR-JIT were high. Youth completed virtual interviews ( M = 10.8, SD = 7.4) over 6–8 weeks. At the 6-month follow-up, teachers reported that youth using VR-JIT had employment rates higher than current national employment rates for youth with disabilities. A multinomial logistic regression revealed VR-JIT engagement was associated with greater employment rates by 6-month follow-up (odds ratio = 1.63, p = .002). This study provides promising evidence that VR-JIT may be feasibly implemented with high fidelity in special education preemployment transition services and can potentially enhance employment outcomes among transition-age youth receiving special education services.