A composite fibrin-based scaffold for controlled delivery of bioactive pro-angiogenetic growth factors

Briganti, Enrica; Spiller, Dario; Mirtelli, Chiara; Kull, Silvia; Counoupas, Claudio; Losi, Paola; Senesi, Sonia; Stefano, Rossella Di; Soldani, Giorgio

doi:10.1016/j.jconrel.2009.09.029

Cited by 68 publications

(58 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Various states of fibrin, such as scaffold, sheets, microparticles and fibrin-coated drug particles have been used as drug delivery systems [48,49]. Growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor-β (TGF-β) can easily bind to the fibrin molecules and be controlled released subsequently by diffusion [50][51][52][53][54][55][56].…”

Section: Fibrinmentioning

confidence: 99%

Overview on Biocompatibilities of Implantable Biomaterials

Wang¹

2013

Advances in Biomaterials Science and Biomedical Applications

View full text Add to dashboard Cite

Section: Fibrinmentioning

confidence: 99%

Overview on Biocompatibilities of Implantable Biomaterials

Wang¹

2013

Advances in Biomaterials Science and Biomedical Applications

View full text Add to dashboard Cite

“…177 Composite scaffolds made with poly(ether)urethanepolydimethylsiloxane/Fbn can also be effectively used as a sustained delivery system for angiogenetic growth factors. 94 Both Fbg and Fbn contain binding sites for various angiogenic factors, including adipose-derived stem cells and bone marrow stem cells. 178,179 Both Fbg and Fbn provide a high seeding efficacy with uniform cell distribution for certain stem cells, such as hematopoietic stem cells, endothelial progenitor cells, smooth muscle cells, and MSCs, which are potentially differentiated into vascular-promoting cells in vitro.…”

Section: Vascular Tissue Regenerationmentioning

confidence: 99%

Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications

Rajangam¹,

An²

2013

IJN

View full text Add to dashboard Cite

Over the past two decades, many types of natural and synthetic polymer-based micro-and nanocarriers, with exciting properties and applications, have been developed for application in various types of tissue regeneration, including bone, cartilage, nerve, blood vessels, and skin. The development of suitable polymers scaffold designs to aid the repair of specific cell types have created diverse and important potentials in tissue restoration. Fibrinogen (Fbg)-and fibrin (Fbn)-based micro-and nanostructures can provide suitable natural matrix environments. Since these primary materials are abundantly available in blood as the main coagulation proteins, they can easily interact with damaged tissues and cells through native biochemical interactions. Fbg-and Fbn-based micro and nanostructures can also be consecutively furnished/ or encapsulated and specifically delivered, with multiple growth factors, proteins, and stem cells, in structures designed to aid in specific phases of the tissue regeneration process. The present review has been carried out to demonstrate the progress made with micro and nanoscaffold applications and features a number of applications of Fbg-and Fbn-based carriers in the field of biomaterials, including the delivery of drugs, active biomolecules, cells, and genes, that have been effectively used in tissue engineering and regenerative medicine.

show abstract

“…Polymers used in controlled delivery of angiogenic factors include synthetic polymers such as poly(glycolic acid), poly(lactic acid) and their copolymer (PLGA) [103,107,108]. In addition, natural polymers such as fibrin [109], collagen [110], alginate [111], chitosan [112], gelatin [113] and other hydrogels [114] can be used in the fabrication of controlled delivery systems. Delivery systems often comprise porous scaffolds, hydrogels or microspheres according to the desired application [104,115].…”

Section: Angiogenic Growth Factors Delivery Technologiesmentioning

confidence: 99%

Advances in Growth Factor Delivery for Therapeutic Angiogenesis

Said¹,

Pickering²,

Mequanint³

2012

J Vasc Res

View full text Add to dashboard Cite

Therapeutic angiogenesis is a new revascularization strategy involving the administration of growth factors to induce new vessel formation. The biology and delivery of angiogenic growth factors involved in vessel formation have been extensively studied but success in translating the angiogenic capacity of growth factors into benefits for vascular disease patients is still limited. This could be attributed to issues related to patient selection, growth factor delivery methods or lack of vessel maturation. Comprehensive understanding of the cellular and molecular cross-talk during the different stages of vascular development is needed for the design of efficient therapeutic strategies. The presentation of angiogenic factors either in series or in parallel using a strategy that mimics physiological events, such as concentration and spatio-temporal profiles, is an immediate requirement for functional blood vessel formation. This review provides an overview of the recent delivery strategies of angiogenic factors and discusses targeting neovascular maturation as a promising approach to induce stable and functional vessels for therapeutic angiogenesis.

show abstract

A composite fibrin-based scaffold for controlled delivery of bioactive pro-angiogenetic growth factors

Cited by 68 publications

References 44 publications

Overview on Biocompatibilities of Implantable Biomaterials

Overview on Biocompatibilities of Implantable Biomaterials

Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications

Advances in Growth Factor Delivery for Therapeutic Angiogenesis

Contact Info

Product

Resources

About