A Comprehensive Appraisal of Chalcones and Their Heterocyclic Analogs as Antimicrobial Agents

Abstract

: Owing to the growing demand of compelling antimicrobial agents, chalcones and their heterocyclic derivatives have engrossed prodigious attention of medicinal chemists as effective clinical template for the synthesis of such agents on account of their structural diversity and molecular flexibility. Chalcones are celebrated as fortunate scaffold in an area of both synthetic as well as natural product chemistry. They are reflected as remarkable section of logically occurring pharmacophore that possess comprehensive scale of biological actions such as anticancer, antimalarial, anticancer, antiviral, antiinflammatory, etc. which in regard proposes them with high degree of assortment and noble therapeutic profile. They act as a crucial intermediate for the synthesis of novel heterocyclic skeletons holding biodynamic behavior. This review emphasize on different aspects of chalcones including their natural sources, recent synthetic methodologies and evaluation of their antimicrobial potential. It is expected as a persuasive compilation on chalcones that may benefit the experts to design potent and less toxic chalcone referents as medicinal agents.

Thiophenyl-chalcone derivatives: Synthesis, antioxidant activity, FMO energies and molecular parameters

“…Heteroaryl chalcones are obtained by modifications of phenyl rings [21,22]. Several studies have shown that heteroaryl chalcones have widespread biological potential such as anti-fungal, antibacterial, antimalarial, anticancer, anti-inflammatory, anti-angiogenic and anti-HIV activities [23,24].…”