A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma

Saçkesen, Cansın; Ercan, Hulya; Dizdar, Evrim Alyamaç; Soyer, Özge; Gümüş, Pınar; Tosun, Berat Nursal; Büyüktuncer, Zehra; Karabulut, Erdem; Besler, Halit Tanju; Kalaycı, Ömer

doi:10.1016/j.jaci.2008.03.035

Cited by 146 publications

(108 citation statements)

References 46 publications

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“…Conversely, several reports have found alterations in different antioxidants in asthma and recent literature in this field seems to indicate conflicting findings. For instance, lower erythrocyte or serum SOD activity has been reported in asymptomatic mild adult asthmatics compared with controls [14,15] and lower levels of SOD have been found in children with mild asthma compared with healthy controls [16]. However, increased SOD activity in red blood cells, [10] and higher levels of SOD in mild stable asthmatics have been observed [17].…”

Section: Discussionmentioning

confidence: 99%

Alterations of Erythrocyte Superoxide Dismutase activity in patients suffering from asthma attacks

Katsoulis

Kontakiotis

Gerou

et al. 2016

Monaldi Arch Chest Dis

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Background. Oxidant-antioxidant imbalance may play an important role in the development and progression of bronchial asthma. However, the role of blood antioxidants especially in asthma exacerbation has not been fully discussed. Objective. This study examines a part of the intracellular antioxidant defense mechanism in asthmatic patients admitted to hospital due to severe exacerbation of their disease. Methods. Peripheral blood Erythrocyte Superoxide Dismutase (SOD) activity was measured in 38 patients (33 men - 5 women, with a mean age of 56±2.8 yrs), using a colorimetric method. On the days of admission and discharge the Forced Expiratory Volume in 1 second (FEV1) and the Partial arterial Oxygen pressure (PaO2) were recorded and correlated with SOD activity at the same time. Results. A statistically significant decrease of SOD activity was observed on the day of admission compared to SOD activity on the day of discharge (43.64±31.78 vs. 96.16±54.05 units/ml, p<0.001), suggesting the presence of oxidative stress during an asthma attack. A statistically significant correlation was observed between FEV1 on admission and SOD activity at the same time (r=0.57, p<0.001). Furthermore, SOD activity on admission was correlated with PaO2 on discharge (r=0.55, p<0.001), as well as SOD on discharge with PaO2 on discharge (r=0.53, p=0.001). Conclusions. Decreased systemic erythrocyte SOD activity was observed during asthma attacks. This activity was correlated with severity criteria such as FEV1 and PaO2. Therefore, it seems that measurement of SOD activity could be a useful tool in the evaluation of an asthma attack. The supplementary administration of antioxidants in the future needs further clarification.

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Section: Discussionmentioning

confidence: 99%

Alterations of Erythrocyte Superoxide Dismutase activity in patients suffering from asthma attacks

Katsoulis

Kontakiotis

Gerou

et al. 2016

Monaldi Arch Chest Dis

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“…22 Furthermore, Sackesen et al also stated that asthmatic children tended to have decreased total body antioxidants, both enzymatic and non-enzymatic, including superoxide dismutase and glutathione peroxidase. 23 Fenech et al reported that in moderate and severe asthma attacks, patients' plasma SOD levels are lower than in normal people, and routine use of steroids in patients with asthma affects SOD levels. 24 Fitzpatrick et al observed that children who had severe asthma attacks tended to have high levels of oxidative stress in the epithelial lining fluid (ELF).…”

Section: Discussionmentioning

confidence: 99%

Superoxide dismutase levels and peak expiratory flow in asthmatic children

Kurniasih

Julia

Setyati

2016

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“…4,23,24,32 Studies also showed that ROS react with peptide bonds or with the side chains of proteins and there is oxidation of amino acids such as lysine, leucine, glutamic acid and valine. [38][39][40] The extent and clinical significance of such oxidation in diseases such as asthma need further studying.…”

Section: Inflammation In Asthmamentioning

confidence: 99%