Alterations of Erythrocyte Superoxide Dismutase activity in patients suffering from asthma attacks

Katsoulis, K.; Kontakiotis, T.; Gerou, Spyridon; Kougioulis, M.; Lithoxopoulou, Hellie; Papakosta, Despoina

doi:10.4081/monaldi.2010.293

Cited by 7 publications

(7 citation statements)

References 29 publications

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“…22 In addition, asthma attacks and oxidative stress may decrease peripheral blood erythrocyte superoxide dismutase activity and contribute to the consequence of cardiovascular diseases. 23,24 Our study showed a dose–response relationship between the number of asthma exacerbations and the development of PAD. This finding suggests that poor asthma control is the key factor associating with the PAD development.…”

Section: Discussionmentioning

confidence: 57%

Asthma Is Associated With a Subsequent Risk of Peripheral Artery Disease

Yao

Shen

et al. 2016

Medicine

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Asthma has been associated with the atherosclerosis risk, but not clear of peripheral artery disease (PAD). We attempted to examine the risk of PAD in patients with asthma.From the insurance claims data of Taiwan, we identified 28,158 newly diagnosed asthma patients in 2000 to 2005 and 56,316 persons without asthma randomly selected into the comparison cohort, frequency matched by sex, age, and the date of diagnosis. Both cohorts were followed up until the end of 2011 to estimate the incident PAD. Adjusted hazard ratios (aHRs) of PAD were estimated using the Cox proportional hazards model after controlling for sex, age, and comorbidities.The incidence of PAD was 1.46 times higher in the asthma cohort than in the comparison cohort, with an aHR of 1.34 [95% confidence interval (CI) = 1.24–1.45]. Incidence of PAD was higher in men, the aged, and those with comorbidities in both cohorts. The aHRs of PAD remained significant for the asthma cohort in all subgroups of sex, age, and the presence of comorbidity. The aHRs of PAD were 14.1 (95% CI = 8.18–24.5) in asthma patients with multiple emergency visits and 22.3 (95% CI = 15.6–31.9) for those with multiple hospitalizations.Although smoking is a potential confounding factor, this study suggests patients with asthma have a significantly higher risk of developing PAD than the general population. The results also support the notion that poor control of asthma status is a key factor in subsequent PAD development.

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Section: Discussionmentioning

confidence: 57%

Asthma Is Associated With a Subsequent Risk of Peripheral Artery Disease

Yao

Shen

et al. 2016

Medicine

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“…These interaction experiments did not stimulate cell death and release of cellular material as suggested by LDH measurements. The H 2 O 2 -poly(I:C) co-stimulation dose-dependently reduced gene and protein levels of SOD2 and partially SOD1, thus mimicking clinical findings of antioxidant deficiency at asthma exacerbation (40). This data supports the potential relevance of our in vitro model.…”

Section: Discussionmentioning

confidence: 76%

Oxidative Stress Attenuates TLR3 Responsiveness and Impairs Anti-viral Mechanisms in Bronchial Epithelial Cells From COPD and Asthma Patients

et al. 2019

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COPD and asthma exacerbations are commonly triggered by rhinovirus infection. Potentially promoting exacerbations, impaired anti-viral signaling and attenuated viral clearance have been observed in diseased bronchial epithelium. Oxidative stress is a feature of inflammation in asthma and COPD and is prominent during exacerbations. It is not known whether oxidative stress affects the anti-viral signaling capacity. Bronchial epithelial cells from asthmatic and COPD donors were infected with rhinovirus or treated with the oxidative stressor H2O2 followed by exposure to the synthetic viral replication intermediate poly(I:C). Poly(I:C) was used to ascertain a constant infection-like burden. Gene and protein levels of antioxidants as well as anti-viral responses were measured 3 and 24 h post poly(I:C) exposure. Rhinovirus infection and poly(I:C) stimulation induced protein levels of the antioxidants SOD1 and SOD2. In asthmatic bronchial epithelial cells pre-treatment with H2O2 dose-dependently decreased the antioxidant response to poly(I:C), suggesting exaggerated oxidative stress. Further, poly(I:C)-induced IFNβ gene expression was reduced after pre-treatment with H2O2. This epithelial effect was associated with a reduced expression of the pattern recognition receptors RIG-I, MDA5 and TLR3 both on gene and protein level. Pre-treatment with H2O2 did not alter antioxidant responses in COPD bronchial epithelial cells and, more modestly than in asthma, reduced poly(I:C)-induced IFNβ gene expression. Knockdown of TLR3 but not RIG-I/MDA5 abrogated impairment of poly(I:C)-induced IFNβ gene expression by H2O2. We developed a method by which we could demonstrate that oxidative stress impairs anti-viral signaling in bronchial epithelial cells from asthmatic and COPD patients, most pronounced in asthma. The impairment apparently reflects reduced responsiveness of TLR3. These present findings shed light on molecular mechanisms potentially causing reduced interferon responses to rhinovirus infection at exacerbations in asthma and COPD. Together, our findings suggest a possible self-perpetuating vicious cycle underlying recurrent exacerbations, leading to an impaired anti-viral response, which in turn leads to viral-induced exacerbations, causing more airway inflammation.

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“…In this context, the study by Katsoulis and coauthors, included in this issue [11], showing decreased levels of erythrocyte SOD activity in patients suffering from an asthma attack and a significant correlation of erythrocyte SOD activity with functional parameters of patients at discharge, suggests a potential role for these measurements in monitoring the level of oxidative stress during asthma attacks and offers, as suggested by the authors, a potential approach for monitoring the health status and the pharmacological response of asthmatic patients.…”

Section: Oxidant-antioxidant Balance In Asthma and The Potential Of Amentioning

confidence: 86%

Oxidant-antioxidant balance in asthma and the potential of antioxidant therapies

Stefano

Gnemmi

Vicari

et al. 2016

Monaldi Arch Chest Dis

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Alterations of Erythrocyte Superoxide Dismutase activity in patients suffering from asthma attacks

Cited by 7 publications

References 29 publications

Asthma Is Associated With a Subsequent Risk of Peripheral Artery Disease

Asthma Is Associated With a Subsequent Risk of Peripheral Artery Disease

Oxidative Stress Attenuates TLR3 Responsiveness and Impairs Anti-viral Mechanisms in Bronchial Epithelial Cells From COPD and Asthma Patients

Oxidant-antioxidant balance in asthma and the potential of antioxidant therapies

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