A Comprehensive Profile of Chemokine Gene Expression in the Tissues of the Female Reproductive Tract in Mice

Abstract

The material cannot be used for any other purpose without further permission of the publisher and is for private use only. There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.

Vaginal Inoculation of Uropathogenic Escherichia coli during Estrus Leads to Genital and Renal Colonization

“…S2 in the supplemental material). Considering known estrous cycle-dependent changes in cytokine expression in the female genital tract ( 47 ), our results suggest that the baseline changes during estrus mask the differences in cytokine and myeloperoxidase levels among mice in the naive, PBS-instilled, and UPEC-instilled groups. The divergence of the results from cytokine measurements and histopathology evaluation is likely the result of capturing UPEC-induced structural changes in tissues in the latter analyses.…”

CCL27 is a crucial regulator of immune homeostasis of the skin and mucosal tissues

“…CCL27 has been detected in mucosal tissues including lungs and reproductive tracts ( Menzies et al., 2020 ; Qiu et al., 2008 ; Sennepin et al., 2017 ; Weston et al., 2019 ; Wick et al., 2008 ), although CCL28 is suggested as the dominant CCR10 ligand expressed in the mucosal tissues ( Burkhardt et al., 2019 ; Lazarus et al., 2003 ; Matsuo et al., 2018 ; Wang et al., 2000 ). We assessed whether CCL27-KO affected the CCL28 expression and compositions of CCR10 + lymphocytes in lungs and female reproductive tracts.…”

“…CCL27 has also been detected in mucosal sites of lungs and reproductive tracts ( Menzies et al., 2020 ; Qiu et al., 2008 ; Sennepin et al., 2017 ; Wick et al., 2008 ). Lungs harbor a small fraction of CCR10-expressing T cells and ILCs ( Weston et al., 2019 ), whereas some other mucosal sites, such as intestines, do not have CCR10 + T cells ( Kunkel et al., 2003 ; Zhao et al., 2020 ).…”

Metamorphic Protein Folding Encodes Multiple Anti-Candida Mechanisms in XCL1

“…Many human chemokines are known to be antifungal [ 13 , 14 , 21 ], including the chemokines XCL1 and CCL28 [ 18 ]. Indeed, a recent study found that XCL1 and CCL28 are expressed highly in uterine tissue, perhaps suggesting that the antimicrobial properties of these chemokines contribute to the protection of the developing fetus from microbial pathogens [ 27 ]. XCL1 has the additional feature of being metamorphic, i.e., switching between multiple different three-dimensional structures reversibly in solution [ 15 ].…”