A comprehensive prognostic and immune analysis of enhancer RNA identifies IGFBP7-AS1 as a novel prognostic biomarker in Uterine Corpus Endometrial Carcinoma

Liu, Jinhui; Yin, Jian; Wang, Yuanyuan; Cai, Lixin; Geng, Rui; Du, Mulong; Zhong, Zihang; Ni, Senmiao; Huang, Xin; Yu, Hao; Bai, Jianling

doi:10.1186/s12575-022-00172-0

Cited by 3 publications

(2 citation statements)

References 52 publications

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“…Apart from these all, antisense lncRNAs can also mitigate EC progression by the stimulation of the immune system activity. They may exert such an effect through various mechanisms, including stimulating the activity of macrophages and other leukocytes, signalling pathways, or cytokine secretion [ 68 , 69 ]. The main characteristics of long non-coding antisense RNAs are summarized in Table 3 .…”

Section: The Role Of Lncrna In Endometrial Cancermentioning

confidence: 99%

The Promotive and Inhibitory Role of Long Non-Coding RNAs in Endometrial Cancer Course—A Review

Jasielski,

Zawlik,

Bogaczyk

et al. 2024

Cancers

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Endometrial cancer is one of the most common malignant tumours in women. The development of this tumour is associated with several genetic disorders, many of which are still unknown. One type of RNA molecules currently being intensively studied in many types of cancer are long non-coding RNAs (lncRNAs). LncRNA-coding genes occupy a large fraction of the human genome. LncRNAs regulate many aspects of cell development, metabolism, and other physiological processes. Diverse types of lncRNA can function as a tumour suppressor or an oncogene that can alter migration, invasion, cell proliferation, apoptosis, and immune system response. Recent studies suggest that selected lncRNAs are important in an endometrial cancer course. Our article describes over 70 lncRNAs involved in the development of endometrial cancer, which were studied via in vivo and in vitro research. It was proved that lncRNAs could both promote and inhibit the development of endometrial cancer. In the future, lncRNAs may become an important therapeutic target. The aim of this study is to review the role of lncRNAs in the development of carcinoma of uterine body.

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Section: The Role Of Lncrna In Endometrial Cancermentioning

confidence: 99%

The Promotive and Inhibitory Role of Long Non-Coding RNAs in Endometrial Cancer Course—A Review

Jasielski,

Zawlik,

Bogaczyk

et al. 2024

Cancers

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show abstract

“…Uterine corpus endometrial carcinoma (UCEC) is considered to be the second cancer and the main cause of death in female cancer patients due to its high recurrence rate ( 1 ). It is a kind of endometrial epithelial malignant tumor with high mortality and a serious threat to women’s health.…”

Section: Introductionmentioning

confidence: 99%

Endoplasmic reticulum stress related IncRNA signature predicts the prognosis and immune response evaluation of uterine corpus endometrial carcinoma

Shen

Yang

2023

Front. Oncol.

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BackgroundEndoplasmic reticulum (ER) stress is closely related to the occurrence, development and treatment of tumors. Recent studies suggest ER stress as a therapeutic strategy of choice for cancer. However, ER stress-related long non-coding RNA (lncRNA) predictive value in endometrial carcinoma (UCEC) remains to be further evaluated. The purpose of this study was to establish relies on the signature of ER stress-related lncRNA forecast to predict the prognosis of patients with UCEC.MethodsWe downloaded the RNA expression profile dataset and matched clinical data from the Cancer Genome Atlas (TCGA) database, and applied univariate and multivariate Cox regression analysis to build predictive signature. Kaplan-meier method was used to evaluate overall survival (OS) and disease-free survival (DFS). Gene set enrichment analysis (GSEA) was used to study the functional characteristics. Single sample Gene set enrichment analysis (ssGSEA) was used to analyze the relationship between immune status and predicted signature. Correlations between the potential usefulness of treatment for UCEC patients and predictive signature were also analyzed.ResultsWe established a signature composed of eight ER stress-related lncRNAs (MIR34AHG, AC073842.2, PINK1AS, AC024909.2, MIR31HG, AC007422.2, AC061992.1, AC003102.1). The signature of ER stress-related lncRNA provided better diagnostic value compared with age and tumor grade, and the area under the receiver operating curve was 0.788. The overall and disease-free survival probability of patients in the high-risk group is lower than that in the low-risk group. GSEA indicated that the pathways were mainly enriched for cancer, immunity and reproduction related pathways. ss-GSEA shows that prediction signature and activation of dendritic cells, immature dendritic cells, T helper cells and immune status of the Treg are significantly related. High-risk groups may against PD - 1/L1 immunotherapy and JNK inhibitors VIII, Z.LLNle.CHO, DMOG and JNK. 9 l more sensitive.ConclusionThe ER stress signature can independently predict the prognosis of UCEC patients, and provide guidance for conventional chemotherapy and immunotherapy of UCEC patients.

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Integrating Transcriptomics and Genetics to Identify Expression Patterns of RNF144B and FYN as Potential Predictors of Bacterial Meningitis

Jiang,

Yu,

Fan

et al. 2024

Preprint

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Bacterial meningitis (BM) requires prompt treatment, especially for neonates, the elderly, and immunocompromised individuals. Understanding the immune response is essential, as it precedes clinical symptoms. However, systematic studies have been lacking. This study identifies immune-related genes that could enhance BM diagnosis and treatment. Mendelian randomization, differential gene expression, and co-expression network analyses revealed key genes linked to BM. RNF144B was identified as a risk gene, correlating with increased neutrophil levels during the initial phase of meningitis, whereas FYN was identified as a protective gene, correlating with increased NKT cells during remission and recovery. Single-cell RNA sequencing and gene set enrichment analyses showed RNF144B expression in monocytes and neutrophils, while FYN was associated with NKT cells. During BM onset, there was an increase in neutrophil proportions and a decrease in NKT cell proportions, indicating a negative correlation. In recovery, RNF144B expression and neutrophil levels decreased, while FYN expression and NKT cell levels rose, underscoring the protective role of NKT cells. FYN may regulate T-cell receptor function in NKT cells, reducing BM risk. This study suggests that the expression patterns of these two genes exhibit significant differences at various stages of the disease, thus offering potential biomarkers for aiding in more accurate diagnoses of BM and monitoring disease progression.

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A comprehensive prognostic and immune analysis of enhancer RNA identifies IGFBP7-AS1 as a novel prognostic biomarker in Uterine Corpus Endometrial Carcinoma

Cited by 3 publications

References 52 publications

The Promotive and Inhibitory Role of Long Non-Coding RNAs in Endometrial Cancer Course—A Review

The Promotive and Inhibitory Role of Long Non-Coding RNAs in Endometrial Cancer Course—A Review

Endoplasmic reticulum stress related IncRNA signature predicts the prognosis and immune response evaluation of uterine corpus endometrial carcinoma

Integrating Transcriptomics and Genetics to Identify Expression Patterns of RNF144B and FYN as Potential Predictors of Bacterial Meningitis

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